Gerber, Vinzenz; Tessier, C.; Marti, Eliane Isabelle (2014). Genetics of upper and lower airway diseases in the horse. Equine veterinary journal, 47(4), pp. 390-397. Wiley-Blackwell 10.1111/evj.12289
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Genetic predispositions for guttural pouch tympany, recurrent laryngeal neuropathy and recurrent airway obstruction (RAO) are well documented. There is also evidence that exercise-induced pulmonary haemorrhage and infectious diseases of the respiratory tract in horses have a genetic component. The clinical expression of equine respiratory diseases with a genetic basis results from complex interactions between the environment and the genetic make-up of each individual horse. The genetic effects are likely to be due to variations in several genes, i.e. they are polygenic. It is therefore unlikely that single gene tests will be diagnostically useful in these disorders. Genetic profiling panels, combining several genetic factors with an assessment of environmental risk factors, may have greater value, but much work is still needed to uncover diagnostically useful genetic markers or even causative variants for equine respiratory diseases. Nonetheless, chromosomal regions associated with guttural pouch tympany, recurrent laryngeal neuropathy and RAO have been identified. The association of RAO with other hypersensitivities and with resistance to intestinal parasites requires further study. This review aims to provide an overview of the available data and current thoughts on the genetics of equine airway diseases.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > ISME Equine Clinic Bern > ISME Equine Clinic, Internal medicine 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research |
UniBE Contributor: |
Gerber, Vinzenz, Marti, Eliane Isabelle |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
0425-1644 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Andrea Gassmann-Suter |
Date Deposited: |
21 Nov 2014 16:00 |
Last Modified: |
05 Dec 2022 14:38 |
Publisher DOI: |
10.1111/evj.12289 |
PubMed ID: |
24773614 |
Uncontrolled Keywords: |
genomics, horse, infectious disease, recurrent airway obstruction, recurrent laryngeal neuropathy |
BORIS DOI: |
10.7892/boris.60127 |
URI: |
https://boris.unibe.ch/id/eprint/60127 |
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