Perioperative nerve blockade: clues from the bench

Suter, M. R.; Siegenthaler, Andreas; Decosterd, I.; Ji, R. R. (2011). Perioperative nerve blockade: clues from the bench. Anesthesiology research and practice, 2011, p. 124898. Cairo (Egypt): Hindawi Publishing Corporation 10.1155/2011/124898

Preview

Text 124898.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview

Peripheral and neuraxial nerve blockades are widely used in the perioperative period. Their values to diminish acute postoperative pain are established but other important outcomes such as chronic postoperative pain, or newly, cancer recurrence, or infections could also be influenced. The long-term effects of perioperative nerve blockade are still controversial. We will review current knowledge of the effects of blocking peripheral electrical activity in different animal models of pain. We will first go over the mechanisms of pain development and evaluate which types of fibers are activated after an injury. In the light of experimental results, we will propose some hypotheses explaining the mitigated results obtained in clinical studies on chronic postoperative pain. Finally, we will discuss three major disadvantages of the current blockade: the absence of blockade of myelinated fibers, the inappropriate duration of blockade, and the existence of activity-independent mechanisms.

Interest & Impact

Downloads

300 since deposited on 04 Oct 2013
24 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item