Schwarz, Frank; Mihatovic, Ilja; Golubovic, Vladimir; Eick, Sigrun; Iglhaut, Theresa; Becker, Jürgen (2014). Experimental peri-implant mucositis at different implant surfaces. Journal of clinical periodontology, 41(5), pp. 513-520. Wiley 10.1111/jcpe.12240
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OBJECTIVES
To histologically and immunologically assess experimental peri-implant mucositis at surface enhanced modified (mod) hydrophilic titanium implants.
MATERIALS AND METHODS
In a split-mouth design (n = 6 foxhounds), four different implants were inserted on each side of the maxilla: three titanium-zirconium alloy implants (TiZr) with either modSLA (sand-blasted, acid etched and chemically mod), modMA (machined, acid etched and chemically mod), or M (machined) surfaces in the transmucosal portion, and one titanium implant with a machined transmucosal portion (TiM). Experimental mucositis was induced at one randomly assigned side (NPC), whereas the contra-lateral maxillary side received mechanical plaque removal three times per week (PC). At 16 weeks, tissue biopsies were processed for histological (primary outcome: apical extension of the inflammatory cell infiltrate measured from the mucosal margin - PM-aICT) and immunohistochemical (CD68 antigen reactivity) analyses. Peri-implant sulcus fluid was analysed for interleukin (IL)-1β, IL-8, matrix metalloproteinase (MMP)-8 and myeloperoxidase (MPO).
RESULTS
Mean PM-aICT values varied between 1.86 (TiZrmodSLA) and 3.40 mm (TiM) in the UPC group, and between 0.88 (TiZrmodSLA) and 2.08 mm (TiZrM) in the PC group. Mean CD68, IL-1β, IL-8, MMP-8 and MPO values were equally distributed between mod- and control implants in both NPC and PC groups.
CONCLUSIONS
The progression of experimental mucositis was comparable at all implant surfaces investigated.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Eick, Sigrun |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0303-6979 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Eveline Carmen Schuler |
Date Deposited: |
19 Jan 2015 16:05 |
Last Modified: |
05 Dec 2022 14:39 |
Publisher DOI: |
10.1111/jcpe.12240 |
PubMed ID: |
24521508 |
Uncontrolled Keywords: |
experimental mucositis, histomorphometry, immunohistochemistry, immunology, surface hydrophilicity |
BORIS DOI: |
10.7892/boris.61673 |
URI: |
https://boris.unibe.ch/id/eprint/61673 |
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