Vicinus, Benjamin; Rubie, Claudia; Faust, Sabrina K; Frick, Vilma Oliveira; Ghadjar, Pirus; Wagner, Mathias; Graeber, Stefan; Schilling, Martin K (2012). miR-21 functionally interacts with the 3'UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells. Cancer letters, 316(1), pp. 105-12. Amsterdam: Elsevier 10.1016/j.canlet.2011.10.031
Full text not available from this repository. (Request a copy)As deregulation of miRNAs and chemokine CCL20 was shown to play a role in colorectal cancer (CRC) pathogenesis, we analyzed the functional interactions of candidate miRNAs with CCL20 mRNA. After target prediction software programs indicated a role for miR-21 in CCL20 regulation, we applied the luciferase reporter assay system to demonstrate that miR-21 functionally interacts with the 3'UTR of CCL20 mRNA and down-regulates CCL20 in miR-21 mimic transfected CRC cell lines (Caco-2, SW480 and SW620). Thus, regulation of CCL20 expression by miR-21 might be a regulatory mechanism involved in progression of CRC.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology |
UniBE Contributor: |
Ghadjar, Pirus |
ISSN: |
0304-3835 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:19 |
Last Modified: |
05 Dec 2022 14:05 |
Publisher DOI: |
10.1016/j.canlet.2011.10.031 |
PubMed ID: |
22099878 |
Web of Science ID: |
000299712400015 |
URI: |
https://boris.unibe.ch/id/eprint/6256 (FactScience: 211166) |
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