Hepatic steatosis is associated with surgical-site infection after hepatic and colorectal surgery.

Kurmann, Anita; Wanner, Beatrice; Martens, Florian; Klasen, Jennifer Margaretha; Stickel, Felix; Montani, Matteo; Candinas, Daniel; Beldi, Guido (2014). Hepatic steatosis is associated with surgical-site infection after hepatic and colorectal surgery. Surgery, 156(1), pp. 109-116. Elsevier 10.1016/j.surg.2014.02.020

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BACKGROUND

Obesity and increased visceral fat deposits are important risk factors for surgical-site infection (SSI). Interestingly, a potential role of hepatic steatosis on complications after extrahepatic surgery remains unknown. The aim of the present study was to investigate the impact of hepatic steatosis on SSI in patients that underwent open abdominal surgery.

METHODS

A total of 231 patients that underwent either liver (n = 116) or colorectal (n = 115) resection and received preoperative contrast-enhanced computed tomography scans were retrospectively investigated. Signal attenuation of the liver parenchyma was measured on computed tomography scans to assess hepatic steatosis.

RESULTS

More SSIs (including types 1, 2, and 3) were found in the group with hepatic steatosis (56/118 [47.5%]) compared with the control group (30/113 [26.6%]; P = .001). Patients with hepatic steatosis showed greater median body mass index than patients without hepatic steatosis (26.6 kg/m(2) [range 16.8-47.0 kg/m(2)] vs 23.2 kg/m(2) [15.9-32.7 kg/m(2)]; P < .001). Patients with hepatic steatosis experienced longer median operation times (297 minutes [52-708 minutes] vs 240 minutes [80-600 minutes]; P = .003). In a multivariate analysis, hepatic steatosis was identified as an independent risk factor for SSI in patients undergoing hepatic (odds ratio 10.33 [95% confidence interval 1.19-89.76]; P = .03) or colorectal (odds ratio 6.67 [95% confidence interval 1.12-39.33]; P = .04) operation.

CONCLUSION

Hepatic steatosis is associated with SSI after hepatic and colorectal operation.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
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04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

UniBE Contributor:

 Kurmann, Anita, Martens, Florian, Klasen, Jennifer Margaretha, Stickel, Felix, Montani, Matteo, Candinas, Daniel, Beldi, Guido Jakob Friedrich

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 0039-6060

Publisher:

 Elsevier

Language:

 English

Submitter:

 Doris Haefelin

Date Deposited:

 23 Feb 2015 11:11

Last Modified:

 05 Dec 2022 14:41

Publisher DOI:

 10.1016/j.surg.2014.02.020

PubMed ID:

 24929762

BORIS DOI:

 10.7892/boris.63557

URI:

 https://boris.unibe.ch/id/eprint/63557

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