Adamantidis, Antoine Roger; Zhang, Feng; de Lecea, Luis; Deisseroth, Karl (2014). Optogenetics: opsins and optical interfaces in neuroscience. Cold Spring Harbor protocols, 2014(8), pp. 815-822. Cold Spring Harbor Laboratory 10.1101/pdb.top083329
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Optogenetics is defined as the integration of optics and genetics to control well-defined events within specified cells of living tissue. In this introduction, we focus on the basic techniques necessary for employing microbial opsins as optogenetic tools in mammalian brains. We provide a guide for the fundamentals of optogenetic application-selecting an opsin, implementing expression of opsins based on the neuroscientific experimental requirements, and adapting the corresponding optical hardware for delivery of light into mammalian brains.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Adamantidis, Antoine Roger |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1940-3402 |
Publisher: |
Cold Spring Harbor Laboratory |
Language: |
English |
Submitter: |
Valentina Rossetti |
Date Deposited: |
27 Feb 2015 10:41 |
Last Modified: |
05 Dec 2022 14:41 |
Publisher DOI: |
10.1101/pdb.top083329 |
PubMed ID: |
25086025 |
BORIS DOI: |
10.7892/boris.63670 |
URI: |
https://boris.unibe.ch/id/eprint/63670 |
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