Batliner, Jasmin; Buehrer, Emanuel; Fey, Martin F; Tschan, Mario P (2012). Inhibition of the miR-143/145 cluster attenuated neutrophil differentiation of APL cells. Leukemia research, 36(2), pp. 237-40. Amsterdam: Elsevier 10.1016/j.leukres.2011.10.006
Full text not available from this repository. (Request a copy)MicroRNAs can influence hematopoietic cell lineage commitment and aberrant expression of hematopoietic miRNAs contributes to AML pathology. We found that miR-143 and miR-145 expression is significantly repressed in primary AML patient samples as compared to neutrophils of healthy donors. Further analysis revealed impaired neutrophil differentiation of APL cells upon inhibition of miR-145 expression. Lastly, we identified p73 as transcriptional regulator of miR-143/145 during neutrophil differentiation of APL cells. Our data suggest that low miR-145 levels in APL, possibly due to aberrant expression of p73 transcription factors, contribute to the differentiation block seen in this disease.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Fey, Martin, Tschan, Mario Paul |
ISSN: |
0145-2126 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:20 |
Last Modified: |
05 Dec 2022 14:05 |
Publisher DOI: |
10.1016/j.leukres.2011.10.006 |
PubMed ID: |
22093444 |
Web of Science ID: |
000298658600021 |
URI: |
https://boris.unibe.ch/id/eprint/6455 (FactScience: 211421) |
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