Denosumab Significantly Increases DXA BMD at Both Trabecular and Cortical Sites: Results From the FREEDOM Study

Bolognese, Michael A; Teglbjærg, Christence Stubbe; Zanchetta, Jose R; Lippuner, Kurt; McClung, Michael R; Brandi, Maria Luisa; Høiseth, Arne; Lakatos, Péter; Moffett, Alfred H; Lorenc, Roman S; Wang, Andrea; Libanati, Cesar (2012). Denosumab Significantly Increases DXA BMD at Both Trabecular and Cortical Sites: Results From the FREEDOM Study. Journal of clinical densitometry, 16(2), pp. 147-153. New York, N.Y.: Elsevier 10.1016/j.jocd.2012.02.006

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Denosumab is an approved therapy for postmenopausal women with osteoporosis at high or increased risk for fracture. In the FREEDOM study, denosumab reduced fracture risk and increased bone mineral density (BMD). We report the spine and hip dual-energy X-ray absorptiometry (DXA) BMD responses from the overall study of 7808 women and from a substudy of 441 participants in which more extensive spine and hip assessments as well as additional skeletal sites were evaluated. Significant BMD improvements were observed as early as 1mo at the lumbar spine, total hip, and trochanter (all p<0.005 vs placebo and baseline). BMD increased progressively at the lumbar spine, total hip, femoral neck, trochanter, 1/3 radius, and total body from baseline to months 12, 24, and 36 (all p<0.005 vs placebo and baseline). BMD gains above the least significant change of more than 3% at 36 months were observed in 90% of denosumab-treated subjects at the lumbar spine and 74% at the total hip, and gains more than 6% occurred in 77% and 38%, respectively. In conclusion, denosumab treatment resulted in significant, early, and continued BMD increases at both trabecular and cortical sites throughout the skeleton over 36mo with important gains observed in most subjects.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Osteoporosis
UniBE Contributor:	Lippuner, Kurt
ISSN:	1094-6950
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:21
Last Modified:	05 Dec 2022 14:06
Publisher DOI:	10.1016/j.jocd.2012.02.006
PubMed ID:	22521543
Web of Science ID:	000319032700007
URI:	https://boris.unibe.ch/id/eprint/6938 (FactScience: 212023)