Karamitopoulou, Evanthia; Zlobec, Inti; Kölzer, Viktor; Langer, Rupert; Dawson, Heather; Lugli, Alessandro (2015). Tumour border configuration in colorectal cancer: proposal for an alternative scoring system based on the percentage of infiltrating margin. Histopathology, 67(4), pp. 464-473. Blackwell Scientific Publications 10.1111/his.12665
Full text not available from this repository. (Request a copy)AIMS
Information on tumour border configuration (TBC) in colorectal cancer (CRC) is currently not included in most pathology reports, owing to lack of reproducibility and/or established evaluation systems. The aim of this study was to investigate whether an alternative scoring system based on the percentage of the infiltrating component may represent a reliable method for assessing TBC.
METHODS AND RESULTS
Two hundred and fifteen CRCs with complete clinicopathological data were evaluated by two independent observers, both 'traditionally' by assigning the tumours into pushing/infiltrating/mixed categories, and alternatively by scoring the percentage of infiltrating margin. With the pushing/infiltrating/mixed pattern method, interobserver agreement (IOA) was moderate (κ = 0.58), whereas with the percentage of infiltrating margins method, IOA was excellent (intraclass correlation coefficient of 0.86). A higher percentage of infiltrating margin correlated with adverse features such as higher grade (P = 0.0025), higher pT (P = 0.0007), pN (P = 0.0001) and pM classification (P = 0.0063), high-grade tumour budding (P < 0.0001), lymphatic invasion (P < 0.0001), vascular invasion (P = 0.0032), and shorter survival (P = 0.0008), and was significantly associated with an increased probability of lymph node metastasis (P < 0.001).
CONCLUSIONS
Information on TBC gives additional prognostic value to pathology reports on CRC. The novel proposed scoring system, by using the percentage of infiltrating margin, outperforms the 'traditional' way of reporting TBC. Additionally, it is reproducible and simple to apply, and can therefore be easily integrated into daily diagnostic practice.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology 04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Karamitopoulou Diamantis, Evanthia, Zlobec, Inti, Kölzer, Viktor, Langer, Rupert, Dawson, Heather, Lugli, Alessandro |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0309-0167 |
Publisher: |
Blackwell Scientific Publications |
Language: |
English |
Submitter: |
Doris Haefelin |
Date Deposited: |
13 Jul 2015 15:24 |
Last Modified: |
02 Mar 2023 23:26 |
Publisher DOI: |
10.1111/his.12665 |
PubMed ID: |
25648412 |
Uncontrolled Keywords: |
colorectal cancer; prognosis; tumour border configuration |
URI: |
https://boris.unibe.ch/id/eprint/70191 |
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