Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers

Perry, George H.; Foll, Matthieu; Grenier, Jean-Christophe; Patin, Etienne; Nédélec, Yohann; Pacis, Alain; Barakatt, Maxime; Gravel, Simon; Zhou, Xiang; Nsobya, Sam L.; Excoffier, Laurent; Quintana-Murci, Lluis; Dominy, Nathaniel J.; Barreiro, Luis B. (2014). Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 111(35), E3596-E3603. National Academy of Sciences NAS 10.1073/pnas.1402875111

Text PNAS-2014-Perry-E3596-603.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB) | Request a copy

Tropical rainforest hunter-gatherer populations worldwide share the pygmy phenotype, or small human body size. The evolutionary history of this phenotype is largely unknown. Here we studied DNA from the Batwa, a rainforest hunter-gatherer population from east central Africa, to identify regions of the Batwa genome that underlie the pygmy phenotype. We then performed population genomic analyses to study the evolution of these regions, including comparisons with the Baka, a west central African rainforest hunter-gatherer population. We conclude that the pygmy phenotype likely arose due to positive natural selection and that it arose possibly multiple times within Africa. These results support longstanding anthropological hypotheses that small body size confers an important selective advantage for human rainforest hunter-gatherers.

Interest & Impact

Downloads

2 since deposited on 10 Sep 2015
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item