Zinkernagel, Martin Sebastian; Wolf, Sebastian; Ebneter, Andreas (2015). Fluctuations in Pigment Epithelial Detachment and Retinal Fluid Using a Bimonthly Treatment Regimen with Aflibercept for Neovascular Age-Related Macular Degeneration. Ophthalmologica, 235(1), pp. 42-48. Karger 10.1159/000441428
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PURPOSE
To assess the effect of a bimonthly treatment regimen with intravitreal aflibercept on retinal fluid and pigment epithelial detachment (PED) in patients with neovascular age-related macular degeneration (AMD).
METHODS
Twenty-six treatment-naive eyes of 26 patients with choroidal neovascularisation secondary to AMD were included. The patients received three initial monthly (mean 30 days) intravitreal injections of aflibercept followed by a bimonthly (mean 62 days) fixed regimen for a total of 1 year. Best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) measurements were recorded at monthly intervals. In addition, the presence of intraretinal fluid (IRF) or subretinal fluid (SRF) or a combination of both as well as serous and fibrovascular PEDs were assessed.
RESULTS
The mean patient age was 80 years (range 54-93). There were 14 male and 12 female patients. The mean gain in BCVA at 1 year was 9.3 letters (SEM ±3) with a mean reduction of the central retinal thickness of 154 µm (SEM ±50). After 3 monthly injections of aflibercept, there was resolution of IRF and SRF in 80% of the treated eyes; the amount of fluid increased at months 4, 6 and 8 with troughs in between. Whereas fibrovascular PEDs remained stable after the loading phase, serous PEDs displayed a seesaw pattern. Patients without retinal pigment epithelium (RPE) atrophy at the end of the 1-year period had significantly better BCVA compared to patients with RPE atrophy (p = 0.03).
CONCLUSION
Despite significant overall BCVA gain, bimonthly intervals seem insufficient to maintain the morphological improvements after the initial loading dose with intravitreal aflibercept.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Zinkernagel, Martin Sebastian, Wolf, Sebastian (B), Ebneter, Andreas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0030-3755 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Andreas Ebneter |
Date Deposited: |
07 Dec 2015 10:17 |
Last Modified: |
02 Mar 2023 23:26 |
Publisher DOI: |
10.1159/000441428 |
PubMed ID: |
26540259 |
BORIS DOI: |
10.7892/boris.73589 |
URI: |
https://boris.unibe.ch/id/eprint/73589 |
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