Implications of intraglandular lymph node metastases in primary carcinomas of the parotid gland

Nisa Hernandez, Lluis; Salmina, Cinzia; Dettmer, Matthias; Arnold, Andreas; Aebersold, Daniel; Borner, Urs; Giger, Roland (2015). Implications of intraglandular lymph node metastases in primary carcinomas of the parotid gland. The Laryngoscope, 125(9), pp. 2099-2106. Wiley 10.1002/lary.25342

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OBJECTIVES/HYPOTHESIS

Assess the diagnostic and prognostic relevance of intraglandular lymph node (IGLN) metastases in primary parotid gland carcinomas (PGCs).

STUDY DESIGN

Retrospective study at a tertiary referral university hospital.

METHODS

We reviewed the records of 95 patients with primary PGCs, treated at least surgically, between 1997 and 2010. We assessed the clinicopathological associations of IGLN metastases, their prognostic significance, and predictive value in the diagnosis of occult neck lymph node metastases

RESULTS

Twenty-four (25.26%) patients had IGLN metastases. This feature was significantly more prevalent in patients with advanced pT status (P = .01), pN status (P < .01), and overall stage (P < .001); high-risk carcinomas (P = .01); as well as in patients with treatment failures (P < .01). IGLN involvement was significantly associated with decreased univariate disease-free survival (P < .001). Positive and negative predictive values and accuracy for IGLN involvement in the detection of occult neck lymph node metastases were 63.64%, 90.48%, and 84.91%, respectively. The diagnostic values were generally higher in patients with low-risk subtype of PGCs.

CONCLUSIONS

IGLN involvement provides prognostic information and is associated with advanced tumoral stage and higher risk of recurrence. This feature could be used as a potential readout to determine whether a neck dissection in clinically negative neck lymph nodes is needed or not.

LEVEL OF EVIDENCE

4.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radio-Onkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radio-Onkologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology

UniBE Contributor:

 Nisa Hernandez, Lluis, Salmina, Cinzia, Dettmer, Matthias, Arnold, Andreas Michael, Aebersold, Daniel Matthias, Borner, Urs, Giger, Roland

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 1531-4995

Publisher:

 Wiley

Language:

 English

Submitter:

 Doris Haefelin

Date Deposited:

 17 Dec 2015 10:40

Last Modified:

 02 Mar 2023 23:27

Publisher DOI:

 10.1002/lary.25342

PubMed ID:

 25946394

Uncontrolled Keywords:

 Parotid gland cancer intraglandular lymph node metastasis neck dissection neck lymph node metastasis prognostic factors

BORIS DOI:

 10.7892/boris.74340

URI:

 https://boris.unibe.ch/id/eprint/74340

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