Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock

Prondzinsky, Roland; Unverzagt, Susanne; Lemm, Henning; Wegener, Nikolas-Arne; Schlitt, Axel; Heinroth, Konstantin M; Dietz, Sebastian; Buerke, Ute; Kellner, Patrick; Loppnow, Harald; Fiedler, Martin G; Thiery, Joachim; Werdan, Karl; Buerke, Michael (2012). Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock. Clinical research in cardiology, 101(5), pp. 375-84. Heidelberg: Springer-Medizin-Verlag 10.1007/s00392-011-0403-3

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The IABP-SHOCK-trial was a morbidity-based randomized controlled trial in patients with infarction-related cardiogenic shock (CS), which used the change of the quantified degree of multiorgan failure as determined by APACHE II score over a 4-day period as primary outcome measure. The prospective hypothesis was that adding IABP therapy to "standard care" would improve CS-triggered multi organ dysfunction syndrome (MODS). The primary endpoint showed no difference between conventionally managed cardiogenic shock patients and those with IABP support. In an inflammatory marker substudy, we analysed the prognostic value of interleukin (IL)-1β, -6, -7, -8, and -10 in patients with acute myocardial infarction complicated by cardiogenic shock.

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