Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection

Haas, Anna; Zimmermann, Kathrin; Graw, Frederik; Slack, Emma; Rusert, Peter; Ledergerber, Bruno; Bossart, Walter; Weber, Rainer; Thurnheer, Maria C; Battegay, Manuel; Hirschel, Bernard; Vernazza, Pietro; Patuto, Nicola; Macpherson, Andrew J; Günthard, Huldrych F; Oxenius, Annette; Swiss HIV Cohort Study, (2011). Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection. Gut, 60(11), pp. 1506-19. London: BMJ Publishing Group 10.1136/gut.2010.224774

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Human systemic antibody responses to commensal microbiota are not well characterised during health and disease. Of particular interest is the analysis of their potential modulation caused by chronic HIV-1 infection which is associated with sustained enteropathy and systemic B cell disturbances reflected by impaired B cell responses and chronic B cell hyperactivity. The mechanisms underlying B cell hyperactivation and the specificities of the resulting hypergammaglobulinaemia are only poorly understood.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
UniBE Contributor:	Raio, Luigi, Thurnheer Zürcher, Maria Christine, Macpherson, Andrew
ISSN:	0017-5749
Publisher:	BMJ Publishing Group
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:22
Last Modified:	05 Dec 2022 14:06
Publisher DOI:	10.1136/gut.2010.224774
PubMed ID:	21515549
Web of Science ID:	000295399600010
URI:	https://boris.unibe.ch/id/eprint/7756 (FactScience: 213082)