Discovering EEG resting state alterations of semantic dementia

Grieder, Matthias; König, Thomas; Kinoshita, Toshihiko; Utsunomiya, Keita; Wahlund, Lars-Olof; Dierks, Thomas; Nishida, Keiichiro (2016). Discovering EEG resting state alterations of semantic dementia. Clinical neurophysiology, 127(5), pp. 2175-2181. Elsevier 10.1016/j.clinph.2016.01.025

Preview	Text Grieder etal_EEG resting state in Semantic Dementia_ClinNeurophysiol_2016_accepted Manuscript.pdf - Accepted Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (1MB) | Preview
	Text Grieder etal_EEG resting state in Semantic Dementia_ClinNeurophysiol_2016.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (908kB) | Request a copy

Objective
Diagnosis of semantic dementia relies on cost-intensive MRI or PET, although resting EEG markers of other dementias have been reported. Yet the view still holds that resting EEG in patients with semantic dementia is normal. However, studies using increasingly sophisticated EEG analysis methods have demonstrated that slightest alterations of functional brain states can be detected.

Methods
We analyzed the common four resting EEG microstates (A, B, C, and D) of 8 patients with semantic dementia in comparison with 8 healthy controls and 8 patients with Alzheimer’s disease.

Results
Topographical differences between the groups were found in microstate classes B and C, while microstate classes A and D were comparable. The data showed that the semantic dementia group had a peculiar microstate E, but the commonly found microstate C was lacking. Furthermore, the presence of microstate E was significantly correlated with lower MMSE and language scores.

Conclusion
Alterations in resting EEG can be found in semantic dementia. Topographical shifts in microstate C might be related to semantic memory deficits.

Significance
This is the first study that discovered resting state EEG abnormality in semantic dementia. The notion that resting EEG in this dementia subtype is normal has to be revised.

Interest & Impact

Downloads

427 since deposited on 22 Mar 2016
90 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item