Inefficient Preparatory fMRI-BOLD Network Activations Predict Working Memory Dysfunctions in Patients with Schizophrenia

Bänninger, Anja; Rieger, Kathryn; Diaz, Laura; Ford, Judith M.; Kottlow, Mara; König, Thomas (2016). Inefficient Preparatory fMRI-BOLD Network Activations Predict Working Memory Dysfunctions in Patients with Schizophrenia. Frontiers in psychiatry, 7(29) Frontiers 10.3389/fpsyt.2016.00029

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Patients with schizophrenia show abnormal dynamics and structure of temporally ­coherent networks (TCNs) assessed using fMRI, which undergo adaptive shifts in preparation for a cognitively demanding task. During working memory (WM) tasks, patients with schizophrenia show persistent deficits in TCNs as well as EEG indices of WM. Studying their temporal relationship during WM tasks might provide novel insights into WM performance deficits seen in schizophrenia. Simultaneous EEG-fMRI data were acquired during the performance of a verbal Sternberg WM task with two load levels (load 2 and load 5) in 17 patients with schizophrenia and 17 matched healthy controls. Using covariance mapping, we investigated the relationship of the activity in the TCNs before the memoranda were encoded and EEG spectral power during the retention interval. We assessed four TCNs – default mode network (DMN), dorsal attention network (dAN), left and right working memory networks (WMNs) – and three EEG bands – theta, alpha, and beta. In healthy controls, there was a load-dependent inverse relation between DMN and frontal midline theta power and an anti-correlation between DMN and dAN. Both effects were not significantly detectable in patients. In addition, healthy controls showed a left-lateralized load-dependent recruitment of the WMNs. Activation of the WMNs was bilateral in patients, suggesting more resources were recruited for successful performance on the WM task. Our findings support the notion of schizophrenia patients showing deviations in their neurophysiological responses before the retention of relevant information in a verbal WM task. Thus, treatment strategies as neurofeedback ­targeting prestates could be beneficial as task performance relies on the preparatory state of the brain.

Item Type: Journal Article (Original Article)
Division/Institute: 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
07 Faculty of Human Sciences > Institute of Psychology > Experimental Psychology and Neuropsychology
04 Faculty of Medicine > Other Institutions > Teaching Staff, Faculty of Medicine
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
Graduate School: Graduate School for Health Sciences (GHS)
UniBE Contributor: Bänninger, Anja; Rieger, Kathryn; Diaz, Laura; Kottlow, Mara and König, Thomas
Subjects: 100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health
ISSN: 1664-0640
Publisher: Frontiers
Funders: [42] Schweizerischer Nationalfonds
Language: English
Submitter: Anja Bänninger
Date Deposited: 22 Mar 2016 08:21
Last Modified: 25 Jan 2017 15:15
Publisher DOI: 10.3389/fpsyt.2016.00029
Uncontrolled Keywords: schizophrenia, working memory, temporally coherent networks, state-dependent information processing, simultaneous EEG-fMRI, covariance mapping
BORIS DOI: 10.7892/boris.80108
URI: http://boris.unibe.ch/id/eprint/80108

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