Schosser, Alexandra; Schloegelhofer, Monika; Fuchs, Karoline; Stojanovic, Mirjana; Mossaheb, Nilufar; Kindler, Jochen; Cohen-Woods, Sarah; Hosang, Georgina; Farmer, Anne; Craig, Ian; McGuffin, Peter; Aschauer, Harald (2011). Bipolar disorder susceptibility region on chromosome 3q29 not confirmed in a case-control association study. World journal of biological psychiatry, 12(4), pp. 309-15. London: Informa Healthcare 10.3109/15622975.2010.551407
Full text not available from this repository. (Request a copy)We identified a bipolar disorder (BPD) susceptibility region on chromosome 3q29 in a genome-wide linkage scan (Bailer et al. 2002 (Biol Psychiatry 52: 40), NPL-score 4.09) and follow-up linkage analysis (Schosser et al. 2004 (J Psychiatr Res 38(3): 357), NPL-scores >3 with five markers). These findings were supported by further fine-mapping of this region (Schosser et al. 2007 (Eur Neuropsychopharmacol 17(6-7): 501)), finding NPL-scores >3.9 with SNPs (single nucleotide polymorphisms) spanning a region of 3.46 Mbp in BPD families. Since genetic association studies are more powerful than linkage studies for detecting susceptibility genes of small effect size, we aimed to replicate these findings in an independent case-control sample collected in London (UK) and Vienna (Austria).
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management |
UniBE Contributor: |
Kindler, Jochen |
ISSN: |
1562-2975 |
Publisher: |
Informa Healthcare |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:24 |
Last Modified: |
05 Dec 2022 14:07 |
Publisher DOI: |
10.3109/15622975.2010.551407 |
PubMed ID: |
21323636 |
Web of Science ID: |
000290405200009 |
URI: |
https://boris.unibe.ch/id/eprint/8433 (FactScience: 213974) |
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