Impact of testosterone on the expression of organic anion transporting polypeptides (OATP-1A2, OATP-2B1, OATP-3A1) in malignant and non-malignant human breast cells in vitro

Stute, Petra; Reichenbach, Anne; Szuwart, Thomas; Kiesel, Ludwig; Götte, Martin (2012). Impact of testosterone on the expression of organic anion transporting polypeptides (OATP-1A2, OATP-2B1, OATP-3A1) in malignant and non-malignant human breast cells in vitro. Maturitas, 71(4), pp. 376-84. Amsterdam: Elsevier 10.1016/j.maturitas.2011.12.020

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Postmenopausal hormone therapy (HT) increases local estrogen formation in breast tissue. The enzymatic substrates depend on transmembrane anion transporting polypeptides (OATPs) to reach intracellular enzymes. The aim of this study was to investigate the effect of testosterone (T) on the expression of OATP-1A2, OATP-2B1, and OATP-3A1 in malignant (MCF-7, BT-474) and non-malignant (HBL-100) breast cells in vitro.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Stute, Petra

ISSN:

0378-5122

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:24

Last Modified:

05 Dec 2022 14:07

Publisher DOI:

10.1016/j.maturitas.2011.12.020

PubMed ID:

22300683

Web of Science ID:

000302434200011

URI:

https://boris.unibe.ch/id/eprint/8674 (FactScience: 214286)

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