Manoharan, Ganesh; Belardi, Jorge A; Du, Zhimin; Lee, Michael; Qiao, Shubin; Serruys, Patrick W; Windecker, Stephan; Xu, Bo; Yeung, Alan (2016). Comparison of Clinical Outcomes After Multivessel Versus Single-Vessel Stenting With the Zotarolimus-Eluting Stent in the RESOLUTE Global Clinical Trial Program. EuroIntervention, 12(13), pp. 1605-1613. Europa Digital & Publishing 10.4244/EIJ-D-16-00079
Full text not available from this repository. (Request a copy)AIMS
To investigate whether long-term (3-year) clinical outcomes after multivessel treatment with the Resolute zotarolimus-eluting stent (R-ZES) were similar to single-vessel treatment.
METHODS AND RESULTS
The RESOLUTE Global Clinical Trial Program enrolled 7618 patients, of whom 1562 underwent multivessel and 6053 single-vessel treatment with the R- ZES. Patients in the multivessel group were more likely to have complex lesions (58% vs 44%, p<0.001). Clinical outcomes were compared using a Cox regression model adjusted by propensity score to account for differences in baseline characteristics. Compared with single-vessel treatment, multivessel treatment was associated with more complex anatomy and longer mean total stent length (57.8±28.6 vs 26.7±15.2 mm, p<0.001). At 3 years, the cumulative incidence of target lesion failure was similar in patients with multivessel and single-vessel treatment (11.0% vs 9.1%, adjusted p=0.986), as was the incidence of cardiac death or target vessel myocardial infarction (6.7% vs 5.7%, adjusted p=0.793), the incidence of clinically driven target lesion revascularization (5.1% vs 4.4%, adjusted p=0.904), and the incidence of Academic Research Consortium definite or probable stent thrombosis (1.2% vs 0.9%, adjusted p=0.544).
CONCLUSIONS
Multivessel treatment with R-ZES provided excellent long-term clinical outcomes that were comparable to those achieved with single-vessel stenting, supporting the efficacy and safety of R-ZES in patients this setting.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Windecker, Stephan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1774-024X |
Publisher: |
Europa Digital & Publishing |
Language: |
English |
Submitter: |
Judith Liniger |
Date Deposited: |
28 Nov 2016 15:46 |
Last Modified: |
05 Dec 2022 14:59 |
Publisher DOI: |
10.4244/EIJ-D-16-00079 |
PubMed ID: |
27773864 |
URI: |
https://boris.unibe.ch/id/eprint/89635 |
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