Metabotropic glutamate receptor 5 neuroimaging in schizophrenia

Akkus, Funda; Treyer, Valerie; Ametamey, Simon M; Johayem, Anass; Buck, Alfred; Hasler, Gregor (2017). Metabotropic glutamate receptor 5 neuroimaging in schizophrenia. Schizophrenia Research, 183, pp. 95-101. Elsevier 10.1016/j.schres.2016.11.008

	Text Akkus_Hasler_2017_mGluR5_schizophrenia.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (687kB) | Request a copy
	Text Schizophrenia_mGluR5_supplement.pdf - Supplemental Material Restricted to registered users only Available under License Publisher holds Copyright. Download (771kB) | Request a copy
Preview	Text Schizophrenia_mGluR5_publ.pdf - Accepted Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (159kB) | Preview

The metabotropic glutamate receptor 5 (mGluR5) is a promising drug target for the treatment of schizophrenia. In this study, we compared mGluR5 distribution volume ration (DVR) in subjects with schizophrenia and healthy controls. Given our previous findings, we matched samples for gender, age, and smoking status. Binding to mGluR5 was determined using positron emission tomography and [(11)C]ABP688, which binds to an allosteric site with high selectivity. DVR in the 15 individuals with schizophrenia did not differ from that of the 15 controls. In both groups, smoking was associated with marked global reductions in mGluR5 availability (on average 23.8%). In nonsmoking subjects with schizophrenia, there was a positive correlation between mGluR5 DVR in the medial orbitofrontal cortex and the use of antipsychotic drugs (r=0.9, p=0.019). Because antipsychotic drugs such as clozapine appeared to have indirect effects on mGluR5 signaling, our findings may be clinically relevant. They also provide promising leads for elucidating the high comorbidity between schizophrenia and tobacco addiction. Low mGluR5 DVR in smokers my represent a risk factor for schizophrenia. Alternatively, smoking may counteract the potential upregulation of mGluR5 by antipsychotic drugs.

Interest & Impact

Downloads

0 since deposited on 23 Feb 2017
54 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item