Gowland, Peter; Fontana, Stefano; Stolz, Martin; Andina, Nicola; Niederhauser, Christoph (2016). Parvovirus B19 Passive Transmission by Transfusion of Intercept® Blood System-Treated Platelet Concentrate. Transfusion medicine and hemotherapy, 43(3), pp. 198-202. Karger 10.1159/000445195
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BACKGROUND
Pathogen reduction methods for blood components are effective for a large number of viruses though less against small, non-enveloped viruses such as Parvovirus B19 (B19V). This article describes the passive transmission by transfusion of two B19V-contaminated pooled platelet concentrates (PCs) which were treated with the Intercept® blood pathogen reduction system.
CASE REPORTS
Two transfusion cases of B19V-contaminated Intercept-treated pooled PCs were described. Due to the analysis delay, the PCs were already transfused. The viral content of each donation was 4.87 × 10(10) IU/ml in case 1and 1.46 × 10(8) IU/ml in case 2. B19V (52 IU/ml) was detected in the recipient of the case 1 PC, whereas no virus could be detected in the case 2 PC recipient. A B19V IgM response and a transient boost of the underlying B19V IgG immune status and was observed in recipient 1. Recipient of the case 2 PC remained B19V IgG- and IgM-negative. B19V DNA sequence and phylogenetic analysis revealed a 100% homology between donor and recipient.
CONCLUSION
This report describes passive B19V transmission by a PC with very high B19 viral load which elicited a transient boost of the B19V immunity, but not by a PC with a lower B19V content, suggesting that there is a B19 viral load threshold value at which B19V inactivation is exceeded.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene) |
UniBE Contributor: |
Andina, Nicola |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1660-3796 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Katrin Kölliker-Schütz |
Date Deposited: |
22 Feb 2017 12:53 |
Last Modified: |
05 Dec 2022 15:01 |
Publisher DOI: |
10.1159/000445195 |
PubMed ID: |
27403092 |
Uncontrolled Keywords: |
Parvovirus B19; Pathogen inactivation; Pathogen reduction; Platelet transfusion; Transfusion-associated infections |
BORIS DOI: |
10.7892/boris.92552 |
URI: |
https://boris.unibe.ch/id/eprint/92552 |
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