Current Role of Dacomitinib in Head and Neck Cancer.

Eliçin, Olgun; Ozsahin, Mahmut (2016). Current Role of Dacomitinib in Head and Neck Cancer. Expert opinion on investigational drugs, 25(6), pp. 735-742. Informa Healthcare 10.1080/13543784.2016.1177022

Text 2016 - Elicin, Ozsahin - Current Role of Dacomitinib in Head and Neck Cancer(2).pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (951kB) | Request a copy

INTRODUCTION

Recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) has a dismal prognosis. With the emergence of monoclonal antibodies and tyrosine kinase inhibitors (TKI) targeting the epidermal growth factor receptor (EGFR), several drugs were developed and tested in HNSCC. To date, the monoclonal antibody cetuximab is the only approved therapy for curative and recurrent/metastatic patients. Other EGFR-targeting drugs either failed in the clinical trials or are still in the early phases of drug development and research.

AREAS COVERED

In this article, previously published data and ongoing studies regarding dacomitinib, a second-generation irreversible TKI, for the treatment of HNSCC are presented and discussed.

EXPERT OPINION

The current body of evidence is not mature enough to indicate the use of dacomitinib for the treatment of HNSCC in curative or in recurrent/metastatic settings. Phase II data suggest the potential of improved outcome in selected recurrent/metastatic HNSCC based on several biomarkers, which need to be evaluated in randomized phase III trials. Meanwhile, an ongoing phase I study is investigating dacomitinib's optimal dosing combined with and without cisplatin in the curative concomitant chemoradiotherapy setting.

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