Unpredicted adverse reaction to omalizumab

Jandus, P; Hausmann, O; Haeberli, G; Gentinetta, T; Mueller, U; Helbling, A (2011). Unpredicted adverse reaction to omalizumab. Journal of investigational allergology & clinical immunology, 21(7), pp. 563-6. Barcelona: Esmon Publicidad

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Despite promising reports of the use of omalizumab as add-on therapy in patients with systemic mastocytosis and recurrent anaphylaxis during specific venom immunotherapy (VIT), unpredicted adverse effects may lead to therapy failure. We present the case of a patient with systemic mastocytosis and Hymenoptera venom allergy who was administered omalizumab as add-on therapy to improve VIT tolerability after repeated severe adverse reactions despite H1/H2-antihistamine prophylaxis. We describe an unexpected discontinuation of omalizumab following successful initiation of VIT in a patient with systemic mastocytosis, with subsequent lack of tolerability of VIT. An interesting aspect of this case is the correlation of basophil activation test results with both clinical tolerability and VIT intolerance.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology
UniBE Contributor:	Hausmann, Oliver, Helbling, Arthur
ISSN:	1018-9068
Publisher:	Esmon Publicidad
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:26
Last Modified:	05 Dec 2022 14:07
PubMed ID:	22312942
Web of Science ID:	000298935200011
URI:	https://boris.unibe.ch/id/eprint/9325 (FactScience: 215025)