Mistaking 2C-P for 2C-B: What a Difference a Letter Makes

Stoller, Adrian; Dolder, PC; Bodmer, M; Hammann, F; Rentsch, KM; Exadaktylos, Aristomenis; Liechti, ME; Liakoni, Evangelia (2017). Mistaking 2C-P for 2C-B: What a Difference a Letter Makes. Journal of analytical toxicology, 41(1), pp. 77-79. Oxford University Press 10.1093/jat/bkw108

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2,5-Dimethoxy-4(n)-propylphenethylamine (2C-P) is a synthetic phenethylamine derivative belonging to the large family of the so-called 2C drugs. These compounds can differ significantly in receptor affinity, potency and duration of action, and an important structural difference is the ligand
in the 4 position of the phenyl ring, such as propyl in 2C-P or bromine in 2,5-dimethoxy-4-bromophenethylamine (2C-B). The 2C drugs are known for their hallucinogenic properties. We present a case of a 19-year-old male admitted to the emergency department with severe hallucinations, mydriasis, tachycardia, agitation and confusion following the use of a substance sold as
2C-B. By using liquid chromatography–mass spectrometry, the more potent substance 2C-P was detected and quantified. On the basis of two blood sample concentrations, the estimated Elimination half-life was 19 h. This case report illustrates and discusses the differences in potency and duration of action of 2C drugs.

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