Stein, Jens Volker; Moalli, Federica; Ackerknecht, Markus (2016). Basic Rules of T Cell Migration. In: Donnadieu, Emmanuel (ed.) Defects in T cell Trafficking and Resistance to Cancer Immunotherapy. Resistance to Targeted Anti-Cancer Therapeutics: Vol. 9 (pp. 1-19). Springer 10.1007/978-3-319-42223-7_1
Full text not available from this repository. (Request a copy)The positive correlation of lymphocyte infiltration into solid tumors with the patient survival, as well as recent successes of checkpoint inhibitors enhancing antitumor responses, have kindled a huge interest in cancer immunotherapy. In fact, adoptive cell therapy (ACT) of tumor-recognizing T cells has led to complete recession of tumors in a subset of melanoma patients. Yet, the molecular mechanisms that guide T cells to infiltrate tumor tissue for the detection and destruction of cancer cells are only incompletely understood. Here, we will give an overview on the basic rules of T cell migration, focusing on extra- and intracellular guidance cues gained primarily from intravital two photon imaging, and relate this with the efficient unfolding of adaptive immune responses. From this, we outline the challenges that T cells face entering and maneuvering inside non-lymphoid tissues including tumor sites.
Item Type: |
Book Section (Book Chapter) |
---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute |
UniBE Contributor: |
Stein, Jens Volker, Moalli, Federica, Ackerknecht, Markus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2196-5501 |
ISBN: |
978-3-319-42221-3 |
Series: |
Resistance to Targeted Anti-Cancer Therapeutics |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Ursula Zingg-Zünd |
Date Deposited: |
28 Mar 2017 11:09 |
Last Modified: |
05 Dec 2022 15:02 |
Publisher DOI: |
10.1007/978-3-319-42223-7_1 |
Uncontrolled Keywords: |
T cell trafficking; Integrins; Small GTPases; Intravital imaging; Extracellular matrix; Guanine exchange factors |
URI: |
https://boris.unibe.ch/id/eprint/95413 |