Sambataro, Fabio; Visintin, Eleonora; Doerig, Nadja; Brakowski, Janis; grosse Holtforth, Martin; Seifritz, Erich; Spinelli, Simona (2017). Altered dynamics of brain connectivity in major depressive disorder at-rest and during task performance. Psychiatry research: Neuroimaging, 259, pp. 1-9. Elsevier 10.1016/j.pscychresns.2016.11.001
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Major depressive disorder (MDD) has been associated with alterations in several functional brain networks. Previous studies investigating brain networks in MDD during the performance of a task have yielded inconsistent results with the function of the brain at rest. In this study, we used functional magnetic resonance imaging at rest and during a goal-directed task to investigate dynamics of functional connectivity in 19 unmedicated patients with MDD and 19 healthy controls across both experimental paradigms. Patients had spatial differences in the default mode network (DMN), in the executive network (EN), and in the dorsal attention network (DAN) compared to controls at rest and during task performance. In patients the amplitude of the low frequency (LFO) oscillations was reduced in the motor and in the DAN networks during both paradigms. There was a diagnosis by paradigm interaction on the LFOs amplitude of the salience network, with increased amplitude change between task and rest in patients relative to controls. Our findings suggest that the function of several networks could be intrinsically affected in MDD and this could be viable phenotype for the investigation on the neurobiological mechanisms of this disorder and its treatment.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine 07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy 07 Faculty of Human Sciences > Institute of Psychology |
UniBE Contributor: |
Grosse Holtforth, Martin |
Subjects: |
600 Technology > 610 Medicine & health 100 Philosophy > 150 Psychology |
ISSN: |
0925-4927 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Salome Irina Rahel Bötschi |
Date Deposited: |
19 Jul 2017 15:50 |
Last Modified: |
30 Mar 2023 16:30 |
Publisher DOI: |
10.1016/j.pscychresns.2016.11.001 |
PubMed ID: |
27918910 |
BORIS DOI: |
10.7892/boris.95638 |
URI: |
https://boris.unibe.ch/id/eprint/95638 |
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