Vyborna, Yuliia; Häner, Robert (8 December 2016). DNA-grafted supramolecular polymers: synthesis, self-assembly and potential applications (Unpublished). In: Chemistry as Innovating Science. Veldhoven, the Netherlands. 06.-08.12.2016.
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Recent advances in DNA nanotechnology led to the development of biocompatible functional materials targeting different applications, including delivery, precise scaffolding, computation, etc. However, a standard toolbox of building blocks used by chemists is largely limited to canonical nucleobases. To further develop the functional potential of synthetic DNA systems, the use of sequence-specific DNA-polymer conjugates has emerged as an exciting alternative approach. Herein, we demonstrate the synthesis and self-assembly properties of monodisperse DNA-pyrene polyphosphate oligomers as essential units for DNA-grafted supramolecular polymers. Such systems become increasingly important for the creation of dynamic and stimuli-responsible materials.
The unique self-recognition properties of oligonucleotides laid the foundation of modern DNA nanotechnology. Over the last two decades, man-made DNA assemblies led to the development of numerous biocompatible functional materials, including drug carriers, nanorobots, and scaffolding platforms. A standard toolbox of building blocks used by chemists in the field is largely limited to four units – A, G, C, T. To further develop the functional potential of synthetic DNA systems, the use of DNA-chromophore conjugates emerges as an exciting approach.
Following our previous findings, we demonstrate herein the synthesis of the DNA-pyrene oligomers and the temperature-induced self-assembly of these conjugates into DNA-grafted supramolecular polymers. (see Figure 1). Such systems become increasingly important for the creation of dynamic and stimuli-responsible materials targeting various applications such as delivery and precise scaffolding.
Item Type: |
Conference or Workshop Item (Poster) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Vyborna, Yuliia, Häner, Robert |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
Language: |
English |
Submitter: |
Yuliia Vyborna |
Date Deposited: |
09 Jun 2017 17:05 |
Last Modified: |
05 Dec 2022 15:03 |
BORIS DOI: |
10.7892/boris.96765 |
URI: |
https://boris.unibe.ch/id/eprint/96765 |
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