Darbre, Tamis

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2016

Michaud, Gaëlle; Visini, Ricardo; Bergmann, Myriam; Salerno, Gianluca; Bosco, Rosa; Gillon, Emilie; Richichi, Barbara; Nativi, Cristina; Imberty, Anne; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2016). Overcoming antibiotic resistance in Pseudomonas aeruginosa biofilms using glycopeptide dendrimers. Chemical Science, 7(1), pp. 166-182. The Royal Society of Chemistry 10.1039/c5sc03635f

Filipe, Luis C. S.; Machuqueiro, Miguel; Darbre, Tamis; Baptista, Antonio M. (2016). Exploring the Structural Properties of Positively Charged peptide Dendrimers. Journal of physical chemistry - B, 120(43), pp. 11323-11330. American Chemical Society 10.1021/acs.jpcb.6b09156

Filipe, Luis C. S.; Campus, Sara R. R.; Machuqueiro, Miguel; Darbre, Tamis; Baptista, Antonio M. (2016). Structuring Peptide Dendrimers through pH Modulation and Substrate Binding. Journal of physical chemistry - B, 120(38), pp. 10138-10152. American Chemical Society 10.1021/acs.jpcb.6b05905

Kwok, Albert; Eggimann, Gabriela A.; Heitz, Marc; Reymond, Jean-Louis; Hollfelder, Florian; Darbre, Tamis (2016). Efficient Transfection of siRNA by Peptide Dendrimer-Lipid Conjugates. ChemBioChem, 17(23), pp. 2223-2229. Wiley-VCH 10.1002/cbic.201600485

Abdel-Sayed, Philippe; Kaeppli, Ariane; Siriwardena, Thissa; Darbre, Tamis; Perron, Karl; Jafari, Paris; Reymond, Jean-Louis; Pioletti, Dominique P.; Applegate, Lee Ann (2016). Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages. Scientific Reports, 6(22020), p. 22020. Nature Publishing Group 10.1038/srep22020

2015

Pires, João; Siriwardena, Thissa N.; Stach, Michaela; Tinguely, Regula; Kasraian Fard, Sara; Luzzaro, Francesco; Leib, Stephen; Darbre, Tamis; Reymond, Jean-Louis; Endimiani, Andrea (2015). In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 59(12), pp. 7915-7918. American Society for Microbiology 10.1128/AAC.01853-15

Bergmann, Myriam; Michaud, Gaëlle; Visini, Ricardo; Jin, Xian; Gillon, Emilie; Stocker, Achim; Imberty, Anne; Darbre, Tamis; Reymond, Jean-Louis (2015). Multivalency effects in Pseudomonas aeruginosa biofilm inhibition and dispersal by glycopeptide dendrimers targeting lectin LecA. Organic & biomolecular chemistry, 14(1), pp. 138-148. Royal Society of Chemistry 10.1039/C5OB01682G

Visini, Ricardo; Bergmann, Myriam; Michaud, Gaelle; Pertici, Francesca; Fu, Ou; Pukin, Aliaksei; Branson, Thomas; Thies-Weesie, Dominique; Kemmink, Johan; Gillon, Emilie; Imberty, Anne; Stocker, Achim; Darbre, Tamis; Pieters, Roland; Reymond, Jean-Louis (2015). Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeroginosa lectin LecA. ACS Chemical Biology, 10(11), pp. 2455-2462. American Chemical Society 10.1021/acschembio.5b00302

Darbre, Tamis (June 2015). Potent Antimicrobial Peptide Dendrimers against Multi-Drug Resistant Pseudomonas aeruginosa (Unpublished). In: American Peptide Symposium. Orlando, FL, USA. 20.-25.06.2015.

Darbre, Tamis (June 2015). Potent Antimicrobial Peptide Dendrimers against Multi-Drug Resistant Pseudomonas aeruginosa (Unpublished). In: Challenges in Chemical Biology (ISACS16). Zürich, Schweiz. 15.-18.06.2015.

Darbre, Tamis (March 2015). Combined Topology and Sequence Design Uncovers Potent Antimicrobial Peptide Dendrimers against Multi-Drug Resistant Pseudomonas aeruginosa (Unpublished). In: German Peptide Symposium Darmstadt. Darmstadt, Deutschland. 21.03.2015.

Perez, Camilo; Gerber, Sabina; Boilevin, Jérémy; Bucher, Monika; Darbre, Tamis; Aebi, Markus; Reymond, Jean-Louis; Locher, Kaspar P. (2015). Structure and mechanism of an active lipid-linked oligosaccharide flippase. Nature, 524(7566), pp. 433-438. Macmillan Journals Ltd. 10.1038/nature14953

Bartoloni, Marco; Jin, Xian; Marcaida, Maria José; Banha, João; Di Bonaventura, Ivan; Bongoni, Swathi; Bartho, Kathrin; Gräbner, Olivia; Sefkow, Michael; Darbre, Tamis; Reymond, Jean-Louis (2015). Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability. Chemical Science, 6(10), pp. 5473-5490. The Royal Society of Chemistry 10.1039/C5SC01699A

2014

Naegeli, A.; Michaud, Gaëlle; Schubert, M.; Lin, C.-W.; Lizak, C.; Darbre, Tamis; Reymond, Jean-Louis; Aebi, M. (2014). Substrate Specificity of Cytoplasmic N-Glycosyltransferase. Journal of biological chemistry, 289(35), pp. 24521-24532. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M114.579326

Michaud, Gaëlle; Bergmann, Myriam; Salerno, Gianluca; Gillon, Emilie; Imberty, Anne; Richichi, Barbara; Nativi, Cristina; Darbre, Tamis; Reymond, Jean-Louis (June 2014). Synthesis of glycopeptide dendrimers targeting LecA, LecB, or both (Unpublished). In: COST MultiGlycoNano Meeting. Siena, Italy. 25.-28.06.2014.

Bartoloni, Marco; Waltersperger, Sandro; Bumann, Mario; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2014). Stereoselective synthesis and structure determination of a bicyclo[3.3.2]decapeptide. Arkivoc, 2014(3), p. 113. Michigan Publishing 10.3998/ark.5550190.p008.500

Stach, Michaela; Siriwardena, Thissa; Köhler, Thilo; van Delden, Christian; Darbre, Tamis; Reymond, Jean-Louis (2014). Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug-Resistant Pseudomonas aeruginosa. Angewandte Chemie (International ed.), 53(47), pp. 12827-12831. Wiley-VCH 10.1002/anie.201409270

Lizak, C.; Gerber, Sabine; Zinne, D.; Michaud, Gaëlle; Schubert, M.; Chen, F.; Bucherer, Monika; Darbre, Tamis; Zenobi, R.; Reymond, Jean-Louis; Locher, K. P. (2014). A Catalytically Essential Motif in External Loop 5 of the Bacterial Oligosaccharyltransferase PglB. Journal of biological chemistry, 289(2), pp. 735-746. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M113.524751

Eggimann, Gabriela A.; Blattes, Emilyne; Buschor, Stefanie; Biswas, Rasomoy; Kammer, Stephan M.; Darbre, Tamis; Reymond, Jean-Louis (2014). Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells. Chemical communications, 50(55), pp. 7254-7257. Royal Society of Chemistry 10.1039/C4CC02780A

2013

Filipe, Luis C. S.; Machuqueiro, Miguel; Baptista, Antonio M.; Darbre, Tamis (2013). Unraveling the Conformational Determinants of Peptide Dendrimers Using Molecular Dynamics Simulations. Macromolecules, 46(23), pp. 9427-9436. American Chemical Society 10.1021/ma401574b

Bernardi, Anna; Jiménez-Barbero, Jesus; Casnati, Alessandro; De Castro, Cristina; Darbre, Tamis; Fieschi, Franck; Finne, Jukka; Funken, Horst; Jaeger, Karl-Erich; Lahmann, Martina; Lindhorst, Thisbe K.; Marradi, Marco; Messner, Paul; Molinaro, Antonio; Murphy, Paul V.; Nativi, Cristina; Oscarson, Stefan; Penadés, Soledad; Peri, Francesco; Pieters, Roland J.; ... (2013). Multivalent glycoconjugates as anti-pathogenic agents. Chemical Society reviews, 42(11), pp. 4709-4727. Royal Society of Chemistry 10.1039/C2CS35408J

Geotti-Bianchini, Piero; Darbre, Tamis; Reymond, Jean-Louis (2013). pH-tuned metal coordination and peroxidase activity of a peptide dendrimer enzyme model with a Fe(ii)bipyridine at its core. Organic & biomolecular chemistry, 11(2), pp. 344-352. Royal Society of Chemistry 10.1039/c2ob26551f

Kadam, Rameshwar U.; Bergmann, Myriam; Garg, Divita; Gabrieli, Gabriele; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2013). Structure-Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors of Pseudomonas aeruginosa Biofilms Targeting LecA. Chemistry - a European journal, 19(50), pp. 17054-17063. Wiley-VCH 10.1002/chem.201302587

Kadam, Rameshwar U.; Garg, Divita; Schwartz, Julian; Visini, Ricardo; Sattler, Michael; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2013). CH−π “T-Shape” Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa Lectin LecA. ACS Chemical Biology, 8(9), pp. 1925-1930. American Chemical Society 10.1021/cb400303w

Ravi, Harish Kumar; Stach, Michaela; Soares, Thereza; Darbre, Tamis; Reymond, Jean-Louis; Cascella, Michele (2013). Electrostatics and Flexibility Drive Membrane Recognition and Early Penetration by Antimicrobial Peptide Dendrimer bH1. Chemical communications, 49(78), pp. 8821-8823. Royal Society of Chemistry 10.1039/C3CC44912B

Reymond, Jean-Louis; Bergmann, Myriam; Darbre, Tamis (2013). Glycopeptide dendrimers as Pseudomonas aeruginosa biofilm inhibitors. Chemical Society reviews, 42(11), pp. 4814-4822. Royal Society of Chemistry 10.1039/c3cs35504g

Gerber, S.; Lizak, C.; Michaud, Gaëlle; Bucher, M.; Darbre, Tamis; Aebi, M.; Reymond, Jean-Louis; Locher, K. P. (2013). Mechanism of bacterial oligosaccharyltransferase: in vitro quantification of sequon binding and catalysis. Journal of biological chemistry, 288(13), pp. 8849-8861. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.445940

Kwok, Albert; Eggimann, Gabriela; Reymond, Jean-Louis; Darbre, Tamis; Hollfelder, Florian (2013). Peptide Dendrimer/Lipid Hybrid Systems Are Efficient DNA Transfection Reagents: Structure–Activity Relationships Highlight the Role of Charge Distribution Across Dendrimer Generations. ACS nano, 7(5), pp. 4668-4682. American Chemical Society 10.1021/nn400343z

Eggimann, Gabriela; Buschor, Stefanie; Darbre, Tamis; Reymond, Jean-Louis (2013). Convergent synthesis and cellular uptake of multivalent cell penetrating peptides derived from Tat, Antp, pVEC, TP10 and SAP. Organic & biomolecular chemistry, 11(39), pp. 6717-6733. Royal Society of Chemistry 10.1039/c3ob41023d

Lizak, Christian; Gerber, Sabina; Michaud, Gaëlle; Schubert, Mario; Fan, Yao-Yun; Bucher, Monika; Darbre, Tamis; Aebi, Markus; Reymond, Jean-Louis; Locher, Kaspar P. (2013). Unexpected reactivity and mechanism of carboxamide activation in bacterial N-linked protein glycosylation. Nature communications, 4(2627), p. 2627. Nature Publishing Group 10.1038/ncomms3627

Reymond, Jean-Louis; Darbre, Tamis (2013). Expanding the Topological Space of Bioactive Peptides. CHIMIA, 67(12), pp. 864-867. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2013.864

2012

Bartoloni, M.; Darbre, Tamis; Reymond, Jean-Louis (2012). Synthesis and structure determination of bicyclic bridged peptides. Journal of Peptide Science, 18(S1), S170-S170. John Wiley & Sons

Blattes, E.; Bartoloni, M.; Darbre, Tamis; Reymond, Jean-Louis (2012). Biological applications of bicyclic peptides. Journal of Peptide Science, 18(Supplement), S93-S93. John Wiley & Sons 10.1002/psc.2449

Darbre, Tamis; Reymond, Jean-Louis (2012). Dendritic glycopeptides as Pseudomonas aeruginosa biofilm inhibitors. Journal of Peptide Science, 18, S55-S56. Chichester: John Wiley & Sons

Eggimann, G.; Buschor, S.; Darbre, Tamis; Reymond, Jean-Louis (2012). Branched and Dendritic Cell Penetrating Peptides. Journal of Peptide Science, 18, S152-S152. Chichester: John Wiley & Sons

Reymond, Jean-Louis; Darbre, Tamis (2012). Peptide and glycopeptide dendrimer apple trees as enzyme models and for biomedical applications. Organic & biomolecular chemistry, 10(8), pp. 1483-1492. Cambridge: Royal Society of Chemistry 10.1039/c2ob06938e

Stach, M.; Darbre, Tamis; Reymond, Jean-Louis (2012). Membrane disrupting antimicrobial peptide dendrimers with multiple amino termini. Journal of Peptide Science, 18, S63-S64. John Wiley & Sons

Stach, Michaela; Maillard, Noélie; Kadam, Rameshwar; Kalbermatter, David; Meury, M.; Page, Malcolm; Fotiadis, Dimitrios José; Darbre, Tamis; Reymond, Jean-Louis (2012). Membrane disrupting antimicrobial peptide dendrimers with multiple amino termini. Medicinal chemistry communications - MedChemComm, 3(1), pp. 86-89. Cambridge: Royal Society of Chemistry 10.1039/c1md00272d

Darbre, T. (2012). Developing therapeutic agents with dendritic and bicyclic peptides, School of Chemistry, Newcastle University, Newcastle upon Tyne, UK, December 11, 2012.

Darbre, T. (2012). Peptide dendrimers for biological applications, Universidade Nova de Lisboa, Lisbon, Portugal, June 4, 2012.

Darbre, T. (2012). Dendritic glycopeptides as Pseudomonas aeruginosa biofilm inhibitors, Oral presentation, 32nd European Peptide symposium, Athens, Greece, 2-7 September 2012.

Darbre, T. (2012). Dendritic peptides for biological applications, Poster presentation, Gordon Research Conference, Bioorganic Chemistry, June 10-15, 2012, Proctor Academy, Andover, NH, USA. In: ohne Verlag.

Darbre, T. (2012). Co-organizer of the CUSO Summer School Chemistry Biology III, Villars sur Ollon, VD, Switzerland, August 26-30, 2012.

2011

Bartoloni, Marco; Kadam, Rameshwar U.; Schwartz, Julian; Furrer, Julien; Darbre, Tamis; Reymond, Jean-Louis (2011). Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides. Chemical communications, 47(47), p. 12634. Cambridge: Royal Society of Chemistry 10.1039/c1cc15704c

Reymond, Jean-Louis; Darbre, Tamis (2011). Combinatorial Libraries of Dendritic Glycoclusters. In: Renaudet, O.; Spinelli, N. (eds.) Synthesis and Biological Applications of Glycoconjugates (pp. 116-128). Bentham Science Publishers

Kadam, Rameshwar U.; Bergmann, Myriam; Hurley, Matthew; Garg, Divita; Cacciarini, Martina; Swiderska, Magdalena A.; Nativi, Cristina; Sattler, Michael; Smyth, Alan R.; Williams, Paul; Camara, Miguel; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2011). A Glycopeptide Dendrimer Inhibitor of the Galactose-Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms. Angewandte Chemie (International ed.), 50(45), pp. 10631-10635. Weinheim: Wiley-VCH 10.1002/anie.201104342

Johansson, Emma M.V.; Kadam, Rameshwar U.; Rispoli, Gabriele; Crusz, Shanika A.; Bartels, Kai-Malte; Diggle, Stephen P.; Camara, Miguel; Williams, Paul; Jaeger, Karl-Erich; Darbre, Tamis; Reymond, Jean-Louis (2011). Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids. Medicinal chemistry communications - MedChemComm, 2(5), pp. 418-420. Cambridge: Royal Society of Chemistry 10.1039/c0md00270d

Maillard, N.; Biswas, Rasomoy; Darbre, Tamis; Reymond, Jean-Louis (2011). Combinatorial Discovery of Peptide Dendrimer Enzyme Models Hydrolyzing Isobutyryl Fluorescein. ACS combinatorial science, 13(3), pp. 310-320. Washington, D.C.: American Chemical Society 10.1021/co200006z

Uhlich, N.A.; Darbre, Tamis; Reymond, Jean-Louis (2011). Peptide dendrimer enzyme models for ester hydrolysis and aldolizationprepared by convergent thioether ligation. Organic & biomolecular chemistry, 9(20), pp. 7071-7084. Cambridge: Royal Society of Chemistry 10.1039/c1ob05877k

2010

Johansson, Emma M.V.; Dubois, Joëlle; Darbre, Tamis; Reymond, Jean-Louis (2010). Glycopeptide dendrimer colchicine conjugates targeting cancer cells. Bioorganic & medicinal chemistry, 18(17), pp. 6589-6597. Amsterdam: Elsevier 10.1016/j.bmc.2010.04.026

Uhlich, Nicolas A.; Natalello, Antonino; Kadam, Rameshwar U.; Doglia, Silvia M.; Reymond, Jean-Louis; Darbre, Tamis (2010). Structure and Binding of Peptide-Dendrimer Ligands to Vitamin B12. ChemBioChem, 11(3), pp. 358-365. Weinheim: Wiley-VCH 10.1002/cbic.200900657

2009

Uhlich, Nicolas A.; Sommer, Peter; Bühr, Claudia; Schürch, Stefan; Reymond, Jean-Louis; Darbre, Tamis (2009). Remote Control of Bipyridine-Metal Coordination within a Peptide Dendrimer. Chemical communications(41), p. 6237. Cambridge: Royal Society of Chemistry 10.1039/b912291e

Sommer, Peter; Fluxa, Viviana S.; Darbre, Tamis; Reymond, Jean-Louis (2009). Proteolysis of Peptide Dendrimers. ChemBioChem, 10(9), pp. 1527-1536. Weinheim: Wiley-VCH 10.1002/cbic.200900060

Maillard, Noélie; Darbre, Tamis; Reymond, Jean-Louis (2009). Identification of Catalytic Peptide Dendrimers by "Off-Bead" in Silica High-Throughput Screening of Combinatorial Libraries. Journal of combinatorial chemistry, 11(4), pp. 667-675. Washington, D.C.: American Chemical Society 10.1021/cc9000289

Kolomiets, Elena; Swiderska, Magdalena A.; Kadam, Rameshwar U.; Johansson, Emma M.V.; Jaeger, Karl-Erich; Darbre, Tamis; Reymond, Jean-Louis (2009). Glycopeptide dendrimers with high affinity for the fucose binding lectin PA-IIL from Pseudomonas aeruginosa. ChemMedChem, 4(4), pp. 562-569. Weinheim: Wiley-VCH 10.1002/cmdc.200800380

Maillard, Noélie; Clouet, Anthony; Darbre, Tamis; Reymond, Jean-Louis (2009). Combinatorial Libraries of Peptide Dendrimers: Design, Synthesis, On-Bead High-Throughput Screening, Bead Decoding and Characterization. Nature protocols, 4(2), pp. 132-142. London: Nature Publishing Group 10.1038/nprot.2008.241

2008

Johansson, Emma M.V.; Crusz, Shanika A.; Kolomiets, Elena; Buts, Lieven; Kadam, Rameshwar U.; Cacciarini, Martina; Bartels, Kai-Malte; Diggle, Stephen P.; Cámara, Miguel; Williams, Paul; Loris, Remy; Nativi, Cristina; Rosenau, Frank; Jaeger, Karl-Erich; Darbre, Tamis; Reymond, Jean-Louis (2008). Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB. Chemistry & biology, 15(12), pp. 1249-1257. San Francisco, Calif.: Current Biology Ltd. 10.1016/j.chembiol.2008.10.009

Duléry, Vincent; Uhlich, Nicolas A.; Maillard, Noélie; Fluxa, Viviana S.; Garcia, Julian; Dumy, Pascal; Renaudet, Olivier; Reymond, Jean-Louis; Darbre, Tamis (2008). A cyclodecapeptide ligand to vitamin B12. Organic & biomolecular chemistry, 6(22), pp. 4134-4141. Cambridge: Royal Society of Chemistry 10.1039/b811234g

Darbre, Tamis; Reymond, Jean-Louis (2008). Glycopeptide dendrimers for biomedical applications. Current topics in medicinal chemistry, 8(14), pp. 1286-1293. Hilversum: Bentham Science Publishers 10.2174/156802608785849058

Sommer, Peter; Uhlich, Nicolas; Reymond, Jean-Louis; Darbre, Tamis (2008). A Peptide Dendrimer Model for Vitamin B(12). ChemBioChem, 9(5), pp. 689-693. Weinheim: Wiley-VCH 10.1002/cbic.200700606

Wedemeyer-Exl, Christina; Darbre, Tamis; Keese, Reinhart (2008). Preparation of Dicyano- and Methylcobinamide from Vitamin B12a. Synthesis - journal of synthetic organic chemistry, 2008(21), pp. 3429-3432. Stuttgart: Thieme 10.1055/s-0028-1083187

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