Grandgirard, Denis

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2016

Perny, Michael; Roccio, Marta; Grandgirard, Denis; Solyga, Magdalena; Senn, Pascal; Leib, Stephen (2016). The Severity of Infection Determines the Localization of Damage and Extent of Sensorineural Hearing Loss in Experimental Pneumococcal Meningitis. Journal of neuroscience, 36(29), pp. 7740-7749. Society for Neuroscience 10.1523/JNEUROSCI.0554-16.2016

Curiao, Tânia; Marchi, Emmanuela; Grandgirard, Denis; León-Sampedro, Ricardo; Viti, Carlo; Leib, Stephen; Baquero, Fernando; Oggioni, Marco R; Martinez, José Luis; Coque, Teresa M (2016). Multiple adaptive routes of Salmonella enterica Typhimurium to biocide and antibiotic exposure. BMC Genomics, 17(491), p. 491. BioMed Central 10.1186/s12864-016-2778-z

Bürki, Sarah Elisabeth; Grandgirard, Denis; Datta, Alexandre N; Hackenberg, Annette; Martin, Florence; Schmitt-Mechelke, Thomas; Leib, Stephen L; Steinlin, Maja (2016). Inflammatory markers in pediatric stroke: An attempt to better understanding the pathophysiology. European journal of paediatric neurology, 20(2), pp. 252-260. Elsevier 10.1016/j.ejpn.2015.12.006

Bally, Lia; Grandgirard, Denis; Leib, Stephen (2016). Inhibition of Hippocampal Regeneration by Adjuvant Dexamethasone in Experimental Infant Rat Pneumococcal Meningitis. Antimicrobial agents and chemotherapy, 60(3), pp. 1841-1846. American Society for Microbiology 10.1128/AAC.02429-15

Hathaway, Lucy Jane; Grandgirard, Denis; Valente, Luca Gabriele; Täuber, Martin G.; Leib, Stephen (2016). Streptococcus pneumoniae capsule determines disease severity in experimental pneumococcal meningitis. Open Biology, 6(3) The Royal Society Publishing 10.1098/rsob.150269

Zürcher, Patrick; Springe, Dirk; Grandgirard, Denis; Leib, Stephen; Grossholz, Marius; Jakob, Stephan; Takala, Jukka; Hänggi, Matthias (2016). A randomized trial of the effects of the noble gases helium and argon on neuroprotection in a rodent cardiac arrest model. BMC neurology, 16, p. 43. BioMed Central 10.1186/s12883-016-0565-8

Baumgartner, Denja; Aebi, Susanne; Grandgirard, Denis; Leib, Stephen; Draeger, Annette; Babiychuk, Eduard; Hathaway, Lucy Jane (2016). Clinical Streptococcus pneumoniae isolates induce differing CXCL8 responses from human nasopharyngeal epithelial cells which are reduced by liposomes. BMC microbiology, 16(1), p. 154. BioMed Central 10.1186/s12866-016-0777-5

2015

Frick, Tamara; Springe, Dirk; Grandgirard, Denis; Leib, Stephen; Hänggi, Matthias (2015). An improved simple rat model for global cerebral ischaemia by induced cardiac arrest. Neurological research, 38(4), pp. 373-380. Maney 10.1179/1743132815Y.0000000090

Liechti, Fabian D; Grandgirard, Denis; Leib, Stephen (2015). Bacterial meningitis: insights into pathogenesis and evaluation of new treatment options: a perspective from experimental studies. Future microbiology, 10(7), pp. 1195-1213. Future Medicine 10.2217/fmb.15.43

Liechti, F D; Grandgirard, Denis; Leib, Stephen (2015). The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis. Neuroscience, 297, pp. 89-94. Elsevier 10.1016/j.neuroscience.2015.03.056

Grandgirard, Denis; Furi, Leonardo; Ciusa, Maria Laura; Baldassarri, Lucilla; Knight, Daniel R; Morrissey, Ian; Largiadèr, Carlo Rodolfo; Leib, Stephen; Oggioni, Marco R (2015). Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression. BMC Genomics, 16(345), p. 345. BioMed Central 10.1186/s12864-015-1544-y

Wang, Junhua; Vuitton, Dominique A; Müller, Norbert; Hemphill, Andrew; Spiliotis, Markus; Blagosklonov, Oleg; Grandgirard, Denis; Leib, Stephen; Shalev, Itay; Levy, Gary; Lu, Xiaomei; Lin, Renyong; Wen, Hao; Gottstein, Bruno (2015). Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4+ CD25+ Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice. PLoS neglected tropical diseases, 9(5), e0003755. Public Library of Science 10.1371/journal.pntd.0003755

Bendel, Stepani; Springe, Dirk; Pereira, Adriano José; Grandgirard, Denis; Leib, Stephen; Putzu, Alessandro; Schlickeiser, Jannis; Jakob, Stephan M.; Takala, Jukka; Hänggi, Matthias (2015). Do different anesthesia regimes affect hippocampal apoptosis and neurologic deficits in a rodent cardiac arrest model? BMC Anaesthesiology, 15(2), p. 2. Biomed Central 10.1186/1471-2253-15-2

Liechti, Fabian D; Bächtold, Fabian; Grandgirard, Denis; Leppert, David; Leib, Stephen (2015). The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis. Journal of neuroinflammation, 12(43), p. 43. BioMed Central 10.1186/s12974-015-0257-0

2014

Ricci, Susanna; Grandgirard, Denis; Wenzel, Michael; Braccini, Tiziana; Salvatore, Paola; Oggioni, Marco R; Leib, Stephen; Koedel, Uwe (2014). Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC infectious diseases, 14(726), p. 726. BioMed Central 10.1186/s12879-014-0726-6

Maffioli, Carola; Grandgirard, Denis; Engler, Olivier; Leib, Stephen (2014). A tick-borne encephalitis model in infant rats infected with langat virus. Journal of neuropathology and experimental neurology, 73(12), pp. 1107-1115. Lippincott Williams & Wilkins 10.1097/NEN.0000000000000131

Coutinho, Leonam G; Christen, Stephan; Bellac, Caroline L; Fontes, Fabrícia; de Souza, Fladjule; Grandgirard, Denis; Leib, Stephen; Agnez-Lima, Lucymara F (2014). The kynurenine pathway is involved in bacterial meningitis. Journal of neuroinflammation, 11(169), p. 169. BioMed Central 10.1186/s12974-014-0169-4

Agyeman, Philipp; Grandgirard, Denis; Leib, Stephen (2014). Pathogenesis and Pathophysiology of Bacterial Infections. In: Scheld, Michael; Whitley, Richard J.; Marra, Christina M. (eds.) Infections of the Central Nervous System (pp. 341-364). Philadelphia, PA, USA: Lippincott Williams & Wilkins

Liechti, Fabian D; Grandgirard, Denis; Leppert, David; Leib, Stephen (2014). Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Infection and immunity, 82(4), pp. 1710-1718. American Society for Microbiology 10.1128/IAI.00073-14

Hirt-Minkowski, Patricia; Marti, Hans-Peter; Hönger, Gideon; Grandgirard, Denis; Leib, Stephen; Amico, Patrizia; Schaub, Stefan (2014). Correlation of serum and urinary matrix metalloproteases/tissue inhibitors of metalloproteases with subclinical allograft fibrosis in renal transplantation. Transplant immunology, 30(1), pp. 1-6. Elsevier 10.1016/j.trim.2013.11.004

Liechti, Fabian D; Stüdle, Nicolas; Theurillat, Regula; Grandgirard, Denis; Thormann, Wolfgang; Leib, Stephen (2014). The mood-stabilizer lithium prevents hippocampal apoptosis and improves spatial memory in experimental meningitis. PLoS ONE, 9(11), e113607. Public Library of Science 10.1371/journal.pone.0113607

Baranger, Kévin; Rivera, Santiago; Liechti, Fabian D; Grandgirard, Denis; Bigas, Judit; Seco, Jesús; Tarrago, Teresa; Leib, Stephen; Khrestchatisky, Michel (2014). Endogenous and synthetic MMP inhibitors in CNS physiopathology. In: Dityatev, Alexander; Wehrle-Haller, Bernhard; Pitkänen, Asla (eds.) Brain Extracellular Matrix in Health and Disease. Progress in Brain Research: Vol. 214 (pp. 313-351). Elsevier 10.1016/B978-0-444-63486-3.00014-1

2013

Coutinho, Leonam G; Grandgirard, Denis; Leib, Stephen L.; Agnez-Lima, Lucymara F (2013). Cerebrospinal-fluid cytokine and chemokine profile in patients with pneumococcal and meningococcal meningitis. BMC infectious diseases, 13(1), p. 326. BioMed Central 10.1186/1471-2334-13-326

Monney, Thierry; Grandgirard, Denis; Leib, Stephen; Hemphill, Andrew (2013). Use of a Th1 Stimulator Adjuvant for Vaccination against Neospora caninum Infection in the Pregnant Mouse Model. Pathogens, 2(2), pp. 193-208. MDPI AG 10.3390/pathogens2020193

Grandgirard, Denis; Gäumann, Rahel; Coulibaly, Boubacar; Dangy, Jean-Pierre; Sie, Ali; Junghanss, Thomas; Schudel, Hans; Pluschke, Gerd; Leib, Stephen L. (2013). The causative pathogen determines the inflammatory profile in cerebrospinal fluid and outcome in patients with bacterial meningitis. Mediators of inflammation, 2013, p. 312476. Hindawi Publishing Corp. 10.1155/2013/312476

2011

Sury, Matthias D.; Vorlet-Fawer, Lorianne; Agarinis, Claudia; Yousefi, Shida; Grandgirard, Denis; Leib, Stephen L.; Christen, Stephan (2011). Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiology of disease, 41(1), pp. 201-208. Amsterdam: Elsevier 10.1016/j.nbd.2010.09.007

Woehrl, Bianca; Klein, Matthias; Grandgirard, Denis; Koedel, Uwe; Leib, Stephen (2011). Bacterial meningitis: current therapy and possible future treatment options. Expert review of anti-infective therapy, 9(11), pp. 1053-1065. London: Expert Reviews 10.1586/ERI.11.129

Hofer, Sandra; Grandgirard, Denis; Burri, Denise; Fröhlich, Tanja K.; Leib, Stephen L. (2011). Bacterial meningitis impairs hippocampal neurogenesis. Journal of neuropathology and experimental neurology, 70(10), pp. 890-899. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/NEN.0b013e3182303f31

Monney, Thierry; Rütti, David; Schorer, Michelle; Debache, Karim; Grandgirard, Denis; Leib, Stephen L.; Hemphill, Andrew (2011). RecNcMIC3-1-R is a microneme- and rhoptry-based chimeric antigen that protects against acute neosporosis and limits cerebral parasite load in the mouse model for Neospora caninum infection. Vaccine, 29(40), pp. 6967-6975. Amsterdam: Elsevier 10.1016/j.vaccine.2011.07.038

Blaser, Cornelia; Wittwer, Matthias; Grandgirard, Denis; Leib, Stephen L. (2011). Adjunctive dexamethasone affects the expression of genes related to inflammation, neurogenesis and apoptosis in infant rat pneumococcal meningitis. PLoS ONE, 6(3), e17840. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0017840

Margos, M.C.; Grandgirard, Denis; Leib, Stephen; Gottstein, Bruno (2011). In vitro induction of lymph node cell proliferation by mouse bone marrow dendritic cells following stimulation with different Echinococcus multilocularis antigens. Journal of helminthology, 85(2), pp. 128-137. Cambridge: Cambridge University Press 10.1017/S0022149X10000878

2010

Grandgirard, Denis; Leib, Stephen L. (2010). Meningitis in neonates: bench to bedside. Clinics in perinatology, 37(3), pp. 655-676. New York, N.Y.: Elsevier 10.1016/j.clp.2010.05.004

Wittwer, Matthias; Grandgirard, Denis; Rohrbach, Janine; Leib, Stephen L. (2010). Tracking the transcriptional host response from the acute to the regenerative phase of experimental pneumococcal meningitis. BMC infectious diseases, 10(176), p. 176. London: BioMed Central 10.1186/1471-2334-10-176

Blaser, Cornelia; Klein, Matthias; Grandgirard, Denis; Wittwer, Matthias; Peltola, Heikki; Weigand, Michael; Koedel, Uwe; Leib, Stephen L. (2010). Adjuvant glycerol is not beneficial in experimental pneumococcal meningitis. BMC infectious diseases, 10(84), p. 84. London: BioMed Central 10.1186/1471-2334-10-84

Grandgirard, Denis; Oberson, Kevin; Bühlmann, Angela; Gäumann, Rahel; Leib, Stephen L. (2010). Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. Antimicrobial agents and chemotherapy, 54(3), pp. 1323-1326. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00812-09

2008

Gehre, F.; Leib, Stephen L.; Grandgirard, Denis; Kummer, Jürg; Bühlmann, Angela; Simon, Franziska; Gäumann, R.; Kharat, A. S.; Täuber, Martin G.; Tomasz, A. (2008). Essential role of choline for pneumococcal virulence in an experimental model of meningitis. Internal medicine journal, 264(2), pp. 143-154. Sydney: Blackwell 10.1111/j.1365-2796.2008.01930.x

Sellner, Johann; Greeve, Isabell; Findling, Oliver; Kamm, Christian P.; Minten, Carsten; Engelhardt, Britta; Grandgirard, Denis; Leib, Stephen L.; Mattle, Heinrich P (2008). Effect of interferon-beta and atorvastatin on Th1/Th2 cytokines in multiple sclerosis. Neurochemistry international, 53(1-2), pp. 17-21. Amsterdam: Elsevier 10.1016/j.neuint.2008.04.004

Grandgirard, Denis; Loeffler, Jutta M.; Fischetti, Vincent A.; Leib, Stephen L. (2008). Phage lytic enzyme Cpl-1 for antibacterial therapy in experimental pneumococcal meningitis. Journal of infectious diseases, 197(11), pp. 1519-1522. Cary, N.C.: Oxford University Press 10.1086/587942

Sellner, Johann; Greeve, I; Findling, O; Grandgirard, Denis; Leib, Stephen L.; Mattle, H P (2008). Atorvastatin does not alter serum levels of sCD95 and sCD95L in multiple sclerosis. Clinical and experimental immunology, 152(2), pp. 280-284. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2249.2008.03630.x

2005

Rhême, Céline; Ehrengruber, Markus U; Grandgirard, Denis (2005). Alphaviral cytotoxicity and its implication in vector development. Experimental physiology, 90(1), pp. 45-52. Blackwell 10.1113/expphysiol.2004.028142

2004

Gianinazzi, Christian; Grandgirard, Denis; Simon, Franziska; Imboden, Hans; Joss, Philipp; Täuber, Martin G.; Leib, Stephen (2004). Apoptosis of hippocampal neurons in organotypic slice culture models: direct effect of bacteria revisited. Journal of neuropathology and experimental neurology, 63(6), pp. 610-617. Lippincott Williams & Wilkins

2003

Gianinazzi, Christian; Grandgirard, Denis; Imboden, Hans; Egger, Lotti; Meli, Damian N; Bifrare, Yoeng-Delphine; Joss, Philipp; Täuber, Martin G.; Borner, Christoph; Leib, Stephen (2003). Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis. Acta neuropathologica, 105(5), pp. 499-507. Springer 10.1007/s00401-003-0672-7

1998

Grandgirard, Denis; Studer, Erwin; Monney, Laurent; Belser, Tanja; Fellay, Isabelle; Borner, Christoph; Michel, Marcel R. (1998). Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2. EMBO journal, 17(5), pp. 1268-1278. Nature Publishing Group 10.1093/emboj/17.5.1268

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