Hemphill, Andrew

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Ruppen, Corinne; Hemphill, Andrew; Sendi, Parham (2017). In vitro activity of gentamicin as an adjunct to penicillin against biofilm group B Streptococcus. Journal of antimicrobial chemotherapy, 72(2), pp. 444-447. Oxford University Press 10.1093/jac/dkw447

Ritler, Dominic; Rufener, Reto; Sager, Heinz; Bouvier, Jacques; Hemphill, Andrew; Lundström Stadelmann, Britta (2017). Development of a movement-based in vitro screening assay for the identification of new anti-cestodal compounds. PLoS neglected tropical diseases, 11(5), e0005618. Public Library of Science 10.1371/journal.pntd.0005618


Horcajo, P; Regidor-Cerrillo, J; Aguado Martinez, Adriana; Hemphill, Andrew; Ortega-Mora, L M (2016). Vaccines for bovine neosporosis: current status and key aspects for development. Parasite immunology, 38(12), pp. 709-723. Wiley 10.1111/pim.12342

Van Voorhis, Wesley C; Adams, John H; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H; Alano, Pietro; Alday, Aintzane; Alemán Resto, Yesmalie; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T; Avery, Simon V; Avery, Vicky M; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; ... (2016). Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS pathogens, 12(7), e1005763. Public Library of Science 10.1371/journal.ppat.1005763

Pastor-Fernández, Iván; Regidor-Cerrillo, Javier; Álvarez-García, Gema; Marugán-Hernández, Virginia; García-Lunar, Paula; Hemphill, Andrew; Ortega-Mora, Luis M (2016). The tandemly repeated NTPase (NTPDase) from Neospora caninum is a canonical dense granule protein whose RNA expression, protein secretion and phosphorylation coincides with the tachyzoite egress. Parasites & Vectors, 9(1), p. 352. BioMed Central 10.1186/s13071-016-1620-4

Imhof, Simon; Fragoso, Cristina; Hemphill, Andrew; Von Schubert, Conrad; Li, Dong; Legant, Wesley; Betzig, Erik; Roditi, Isabel (2016). Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication? F1000Research, 5(682), p. 682. F1000 Research Ltd 10.12688/f1000research.8249.1

Aguado Martinez, Adriana; Silva Pinto Basto, Afonso; Müller, Joachim; Balmer, Vreni; Manser, Vera; Leitão, Alexandre; Hemphill, Andrew (2016). N-terminal fusion of a toll-like receptor 2-ligand to a Neospora caninum chimeric antigen efficiently modifies the properties of the specific immune response. Parasitology, 143(5), pp. 606-616. Cambridge University Press 10.1017/S0031182016000056

Stadelmann, Britta; Rufener, Reto; Aeschbacher, Denise; Spiliotis, Markus; Gottstein, Bruno; Hemphill, Andrew (2016). Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis. PLoS neglected tropical diseases, 10(3), e0004535. Public Library of Science 10.1371/journal.pntd.0004535

Hemphill, Andrew; Aguado Martinez, Adriana; Müller, Joachim (2016). Approaches for the vaccination and treatment of Neospora caninum infections in mice and ruminant models. Parasitology, 143(3), pp. 245-259. Cambridge University Press 10.1017/S0031182015001596

Pastor-Fernández, Iván; Regidor-Cerrillo, Javier; Jiménez-Ruiz, Elena; Álvarez-García, Gema; Marugán-Hernández, Virginia; Hemphill, Andrew; Ortega-Mora, Luis M (2016). Characterization of the Neospora caninum NcROP40 and NcROP2Fam-1 rhoptry proteins during the tachyzoite lytic cycle. Parasitology, 143(1), pp. 97-113. Cambridge University Press 10.1017/S0031182015001511

Arranz-Solis, David; Benavides, Julio; Regidor-Cerrillo, Javier; Horcajo, Pilar; Castaño, Pablo; del Carmen Ferreras, María; Jiménez-Pelayo, Laura; Collantes-Fernández, Esther; Ferre, Ignacio; Hemphill, Andrew; Pérez, Valentín; Ortega-Mora, Luis Miguel (2016). Systemic and local immune responses in sheep after Neospora caninum experimental infection at early, mid and late gestation. Veterinary research, 47, p. 2. BioMed Central 10.1186/s13567-015-0290-0

Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Wong, Ho Ning; Haynes, Richard K; Hemphill, Andrew (2016). Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model. Veterinary research, 47, p. 32. BioMed Central 10.1186/s13567-016-0317-1

Fadda, Angela; Bärtschi, Michelle; Hemphill, Andrew; Widmer, Hans Rudolf; Zurbriggen, Andreas; Perona, P; Vidondo Curras, Beatriz; Oevermann, Anna (2016). Primary Postnatal Dorsal Root Ganglion Culture from Conventionally Slaughtered Calves. PLoS ONE, 11(12), e0168228. Public Library of Science 10.1371/journal.pone.0168228


Küster, Tatiana; Stadelmann, Britta; Rufener, Reto; Risch, Corina; Müller, Joachim; Hemphill, Andrew (2015). Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin. International journal of antimicrobial agents, 46(5), pp. 546-551. Elsevier 10.1016/j.ijantimicag.2015.07.016

Gottstein, Bruno; Wang, Junhua; Boubaker, Ghalia; Marinova, Irina; Spiliotis, Markus; Müller, Norbert; Hemphill, Andrew (2015). Susceptibility versus resistance in alveolar echinococcosis (larval infection with Echinococcus multilocularis). Veterinary parasitology, 213(3-4), pp. 103-109. Elsevier 10.1016/j.vetpar.2015.07.029

Winzer, Pablo Arnold; Müller, Joachim; Aguado Martinez, Adriana; Rahman, Mahbubur; Balmer, Vreni; Manser, Vera; Ortega-Mora, Luis Miguel; Ojo, Kayode K; Fan, Erkang; Maly, Dustin J; Van Voorhis, Wesley C; Hemphill, Andrew (2015). In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum. Antimicrobial agents and chemotherapy, 59(10), pp. 6361-6374. American Society for Microbiology 10.1128/AAC.01236-15

Arranz Solis, David; Aguado Martinez, Adriana; Müller, Joachim; Regidor-Cerrillo, Javier; Ortega-Mora, Luis Miguel; Hemphill, Andrew (2015). Dose-dependent effects of experimental infection with the virulent Neospora caninum Nc-Spain7 isolate in a pregnant mouse model. Veterinary parasitology, 211(3-4), pp. 133-140. Elsevier 10.1016/j.vetpar.2015.05.021

Müller, Joachim; Balmer, Vreni; Winzer, Pablo Arnold; Rahman, Mahbubur; Manser, Vera; Haynes, Richard K; Hemphill, Andrew (2015). In vitro effects of new artemisinin derivatives in Neospora caninum-infected human fibroblasts. International journal of antimicrobial agents, 46(1), pp. 88-93. Elsevier 10.1016/j.ijantimicag.2015.02.020

Boubaker, Ghalia; Hemphill, Andrew; Huber, Cristina Olivia; Spiliotis, Markus; Babba, Hamouda; Gottstein, Bruno (2015). Prevention and Immunotherapy of Secondary Murine Alveolar Echinococcosis Employing Recombinant EmP29 Antigen. PLoS neglected tropical diseases, 9(6), e0003795. Public Library of Science 10.1371/journal.pntd.0003795

Wang, Junhua; Vuitton, Dominique A; Müller, Norbert; Hemphill, Andrew; Spiliotis, Markus; Blagosklonov, Oleg; Grandgirard, Denis; Leib, Stephen; Shalev, Itay; Levy, Gary; Lu, Xiaomei; Lin, Renyong; Wen, Hao; Gottstein, Bruno (2015). Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4+ CD25+ Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice. PLoS neglected tropical diseases, 9(5), e0003755. Public Library of Science 10.1371/journal.pntd.0003755

Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Balmer, Vreni; Winzer, Pablo Arnold; Ritler, Dominic; Hostettler, Isabel; Arranz Solis, David; Ortega-Mora, Luis; Hemphill, Andrew (2015). Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice. International Journal for Parasitology: Drugs and Drug Resistance, 5(1), pp. 16-25. Elsevier 10.1016/j.ijpddr.2015.02.001

Reichel, Michael P; Moore, Dadín P; Hemphill, Andrew; Ortega-Mora, Luis M; Dubey, J P; Ellis, John T (2015). A live vaccine against Neospora caninum abortions in cattle. Vaccine, 33(11), pp. 1299-1301. Elsevier 10.1016/j.vaccine.2015.01.064

Arranz Solis, David; Benavides, Julio; Regidor-Cerrillo, Javier; Fuertes, Miguel; Ferre, Ignacio; Ferreras, Maria Del Carmen; Collantes-Fernández, Esther; Hemphill, Andrew; Pérez, Valentín; Ortega-Mora, Luis Miguel (2015). Influence of the gestational stage on the clinical course, lesional development and parasite distribution in experimental ovine neosporosis. Veterinary research, 46, p. 19. Editions scientifiques Elsevier 10.1186/s13567-014-0139-y

Pastor-Fernández, Iván; Arranz-Solís, David; Regidor-Cerrillo, Javier; Álvarez-García, Gema; Hemphill, Andrew; García-Culebras, Alicia; Cuevas-Martín, Carmen; Ortega-Mora, Luis M (2015). A vaccine formulation combining rhoptry proteins NcROP40 and NcROP2 improves pup survival in a pregnant mouse model of neosporosis. Veterinary parasitology, 207(3-4), pp. 203-215. Elsevier 10.1016/j.vetpar.2014.12.009

Naguleswaran, Arunasalam; Gunasekera, Kapila; Schimanski, Bernd; Heller, Manfred; Hemphill, Andrew; Ochsenreiter, Torsten; Roditi, Isabel (2015). Trypanosoma brucei RRM1 is a nuclear RNA-binding protein and modulator of chromatin structure. mBio, 6(2), e00114. American Society for Microbiology 10.1128/mBio.00114-15


Hostettler, Isabel; Müller, Joachim; Stephens, Chad E; Haynes, Richard; Hemphill, Andrew (2014). A quantitative reverse-transcriptase PCR assay for the assessment of drug activities against intracellular Theileria annulata schizonts. International Journal for Parasitology: Drugs and Drug Resistance, 4(3), pp. 201-209. Elsevier 10.1016/j.ijpddr.2014.09.003

Stadelmann, Britta; Aeschbacher, Denise; Huber, Cristina; Spiliotis, Markus; Müller, Joachim; Hemphill, Andrew (2014). Profound activity of the anti-cancer drug bortezomib against Echinococcus multilocularis metacestodes identifies the proteasome as a novel drug target for cestodes. PLoS neglected tropical diseases, 8(12), e3352. Public Library of Science 10.1371/journal.pntd.0003352

Cortes, Helder; Leitão, Alexandre; Gottstein, Bruno; Hemphill, Andrew (2014). A review on bovine besnoitiosis: a disease with economic impact in herd health management, caused by Besnoitia besnoiti (Franco and Borges, 1916). Parasitology, 141(11), pp. 1406-1417. Cambridge University Press 10.1017/S0031182014000262

Hemphill, Andrew; Leitão, Alexandre (2014). ApiCOWplexa 2013--2nd International Meeting on Apicomplexan Parasites in Farm Animals. Parasitology, 141(11), pp. 1355-1358. Cambridge University Press 10.1017/S0031182014001164

Boubaker, Ghalia; Gottstein, Bruno; Hemphill, Andrew; Babba, Hamouda; Spiliotis, Markus (2014). Echinococcus P29 antigen: molecular characterization and implication on post-surgery follow-up of CE patients infected with different species of the Echinococcus granulosus complex. PLoS ONE, 9(5), e98357. Public Library of Science 10.1371/journal.pone.0098357

Monney, Thierry; Hemphill, Andrew (2014). Vaccines against neosporosis: what can we learn from the past studies? Experimental parasitology, 140, pp. 52-70. Elsevier 10.1016/j.exppara.2014.02.015

Küster, Tatiana; Stadelmann, Britta; Aeschbacher, Denise; Hemphill, Andrew (2014). Activities of fenbendazole in comparison with albendazole against Echinococcus multilocularis metacestodes in vitro and in a murine infection model. International journal of antimicrobial agents, 43(4), pp. 335-342. Elsevier 10.1016/j.ijantimicag.2014.01.013

Küster, Tatiana; Kriegel, Nadja; Stadelmann, Britta; Wang, Xiaofang; Dong, Yuxiang; Vennerstrom, Jonathan L; Keiser, Jennifer; Hemphill, Andrew (2014). Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes. International journal of antimicrobial agents, 43(1), pp. 40-46. Elsevier 10.1016/j.ijantimicag.2013.09.012

Hemphill, Andrew; Stadelmann, Britta; Rufener, Reto; Spiliotis, Markus; Boubaker, Ghalia; Müller, Joachim; Müller, Norbert; Gorgas, Daniela; Gottstein, Bruno (2014). Treatment of echinococcosis: albendazole and mebendazole - what else? Parasite, 21, p. 70. Princeps Editions 10.1051/parasite/2014073

Ojo, Kayode K; Reid, Molly C; Kallur Siddaramaiah, Latha; Müller, Joachim; Winzer, Pablo Arnold; Zhang, Zhongsheng; Keyloun, Katelyn R; Vidadala, Rama Subba Rao; Merritt, Ethan A; Hol, Wim G J; Maly, Dustin J; Fan, Erkang; Van Voorhis, Wesley C; Hemphill, Andrew (2014). Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy. PLoS ONE, 9(3), e92929. Public Library of Science 10.1371/journal.pone.0092929

Hemer, Sarah; Konrad, Christian; Spiliotis, Markus; Koziol, Uriel; Schaack, Dominik; Förster, Sabine; Gelmedin, Verena; Stadelmann, Britta; Dandekar, Thomas; Hemphill, Andrew; Brehm, Klaus (2014). Host insulin stimulates Echinococcus multilocularis insulin signalling pathways and larval development. BMC biology, 12, p. 5. BioMed Central 10.1186/1741-7007-12-5


Barna, Fabienne; Debache, Karim; Vock, Carsten A.; Küster, Tatiana; Hemphill, Andrew (2013). In vitro effects of novel ruthenium complexes in Neospora caninum and Toxoplasma gondii tachyzoites. Antimicrobial agents and chemotherapy, 57(11), pp. 5747-5754. American Society for Microbiology 10.1128/AAC.02446-12

Küster, Tatiana; Kriegel, Nadja; Boykin, David W.; Stephens, Chad E.; Hemphill, Andrew (2013). In vitro and in vivo activities of dicationic diguanidino compounds against Echinococcus multilocularis metacestodes. Antimicrobial agents and chemotherapy, 57(8), pp. 3829-3835. American Society for Microbiology 10.1128/AAC.02569-12

Alaeddine, Ferial; Hemphill, Andrew; Debache, Karim; Guionaud, Christophe (2013). Molecular cloning and characterization of NcROP2Fam-1, a member of the ROP2 family of rhoptry proteins in Neospora caninum that is targeted by antibodies neutralizing host cell invasion in vitro. Parasitology, 140(8), pp. 1033-1050. Cambridge University Press 10.1017/S0031182013000383

Spekker, K.; Leineweber, M.; Degrandi, D.; Ince, V.; Brunder, S.; Schmidt, S. K.; Stuhlsatz, S.; Howard, J. C.; Schares, G.; Degistirici, O.; Meisel, R.; Sorg, R. V.; Seissler, J.; Hemphill, Andrew; Pfeffer, K.; Däubener, W. (2013). Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs). Medical microbiology and immunology, 202(3), pp. 197-206. Springer 10.1007/s00430-012-0281-y

Hemphill, Andrew; Debache, Karim; Monney, Thierry; Schorer, Michelle; Gouinaud, Christophe; Alaeddine, Ferial; Müller, Norbert; Müller, Joachim (2013). Proteins mediating the Neospora caninum-host cell interaction as targets for vaccination. Frontiers in Bioscience (Elite Edition), 5, pp. 23-36. Frontiers in Bioscience

Debache, Karim; Hemphill, Andrew (2013). Differential effects of intranasal vaccination with recombinant NcPDI in different mouse models of Neospora caninum infection. Parasite immunology, 35(1), pp. 11-20. Blackwell Scientific Publications 10.1111/pim.12013

Küster, Tatiana; Hermann, Corina; Hemphill, Andrew; Gottstein, Bruno; Spiliotis, Markus (2013). Subcutaneous infection model facilitates treatment assessment of secondary Alveolar echinococcosis in mice. PLoS neglected tropical diseases, 7(5), e2235. Public Library of Science 10.1371/journal.pntd.0002235

Mols-Vorstermans, Tanja; Hemphill, Andrew; Monney, Thierry; Schaap, Dick; Boerhout, Eveline (2013). Differential Effects on Survival, Humoral Immune Responses and Brain Lesions in Inbred BALB/C, CBA/CA, and C57BL/6 Mice Experimentally Infected with Neospora caninum Tachyzoites. ISRN Parasitology, 2013, pp. 1-11. Hindawi 10.5402/2013/830980

Monney, Thierry; Grandgirard, Denis; Leib, Stephen; Hemphill, Andrew (2013). Use of a Th1 Stimulator Adjuvant for Vaccination against Neospora caninum Infection in the Pregnant Mouse Model. Pathogens, 2(2), pp. 193-208. MDPI AG 10.3390/pathogens2020193

Hemphill, Andrew; Müller, Norbert; Müller, Joachim (2013). Thiazolides, a Novel Class of Anti-Infective Drugs, Effective Against Viruses, Bacteria, Intracellular and Extracellular Protozoan Parasites and Proliferating Mammalian Cells. Anti-infective agents in medicinal chemistry, 11(1), pp. 22-30. Bentham Science 10.2174/22113626130103


Zysset-Burri, Denise Corinne; Gottstein, Bruno; Zumkehr, Béatrice; Hemphill, Andrew; Schürch, Nadia; Wittwer, Matthias; Müller, Norbert (2012). Development of a high- versus low-pathogenicity model of the free-living amoeba Naegleria fowleri. Microbiology, 158(Pt 10), pp. 2652-2660. Society for General Microbiology 10.1099/mic.0.059790-0

Küster, Tatiana; Zumkehr, Beatrice; Hermann, Corina; Theurillat, Regula; Thormann, Wolfgang; Gottstein, Bruno; Hemphill, Andrew (2012). Voluntary ingestion of antiparasitic drugs emulsified in honey represents an alternative to gavage in mice. American Association for Laboratory Animal Science Journal, 51(2), pp. 219-223. American Association for Laboratory Animal Science

Sidler, D; Brockmann, A; Mueller, J; Nachbur, U; Corazza, N; Renzulli, P; Hemphill, A; Brunner, T (2012). Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles' heel. Oncogene, 31(37), pp. 4095-106. Basingstoke, UK: Nature Publishing Group 10.1038/onc.2011.575

Kropf, C; Debache, K; Rampa, C; Barna, F; Schorer, M; Stephens, C E; Ismail, M A; Boykin, D W; Hemphill, A (2012). The adaptive potential of a survival artist: characterization of the in vitro interactions of Toxoplasma gondii tachyzoites with di-cationic compounds in human fibroblast cell cultures. Parasitology, 139(2), pp. 208-20. London: Cambridge University Press 10.1017/S0031182011001776


Monney, Thierry; Rütti, David; Schorer, Michelle; Debache, Karim; Grandgirard, Denis; Leib, Stephen L.; Hemphill, Andrew (2011). RecNcMIC3-1-R is a microneme- and rhoptry-based chimeric antigen that protects against acute neosporosis and limits cerebral parasite load in the mouse model for Neospora caninum infection. Vaccine, 29(40), pp. 6967-6975. Amsterdam: Elsevier 10.1016/j.vaccine.2011.07.038

Cortes, H.C.; Muller, N.; Boykin, D.; Stephens, C.E.; Hemphill, A. (2011). In vitro effects of arylimidamides against Besnoitia besnoiti infection in Vero cells. Parasitology, 138(5), pp. 583-92. London: Cambridge University Press 10.1017/S0031182011000114

Debache, K.; Guionaud, C.; Kropf, C.; Boykin, D.; Stephens, C.E.; Hemphill, A. (2011). Experimental treatment of Neospora caninum-infected mice with the arylimidamide DB750 and the thiazolide nitazoxanide. Experimental parasitology, 129(2), pp. 95-100. Amsterdam: Elsevier 10.1016/j.exppara.2011.07.010

Debache, K.; Kropf, C.; Schutz, C.A.; Harwood, L.J.; Kauper, P.; Monney, T.; Rossi, N.; Laue, C.; McCullough, K.C.; Hemphill, A. (2011). Vaccination of mice with chitosan nanogel-associated recombinant NcPDI against challenge infection with Neospora caninum tachyzoites. Parasite immunology, 33(2), pp. 81-94. Oxford: Blackwell Scientific Publications 10.1111/j.1365-3024.2010.01255.x

Kuster, T.; Stadelmann, B.; Hermann, C.; Scholl, S.; Keiser, J.; Hemphill, A. (2011). In vitro and in vivo efficacies of mefloquine-based treatment against alveolar echinococcosis. Antimicrobial agents and chemotherapy, 55(2), pp. 713-21. Washington, D.C.: American Society for Microbiology 10.1128/AAC.01392-10

Marcelino, E.; Martins, T.M.; Morais, J.B.; Nolasco, S.; Cortes, H.; Hemphill, A.; Leitao, A.; Novo, C. (2011). Besnoitia besnoiti protein disulfide isomerase (BbPDI): molecular characterization, expression and in silico modelling. Experimental parasitology, 129(2), pp. 164-74. Amsterdam: Elsevier 10.1016/j.exppara.2011.06.012

Marugan-Hernandez, V.; Alvarez-Garcia, G.; Tomley, F.; Hemphill, A.; Regidor-Cerrillo, J.; Ortega-Mora, L.M. (2011). Identification of novel rhoptry proteins in Neospora caninum by LC/MS-MS analysis of subcellular fractions. Journal of proteomics, 74(5), pp. 629-42. Amsterdam: Elsevier 10.1016/j.jprot.2011.02.004

Mejri, N.; Muller, N.; Hemphill, A.; Gottstein, B. (2011). Intraperitoneal Echinococcus multilocularis infection in mice modulates peritoneal CD4+ and CD8+ regulatory T cell development. Parasitology international, 60(1), pp. 45-53. Amsterdam: Elsevier 10.1016/j.parint.2010.10.002

Müller, J.; Müller, N.; Hemphill, A. (2011). Drugs and drug targets in Neospora caninum and related apicomplexans. In: Becker, Katja (ed.) Apicomplexan Parasites. Drug discovery in Infectious Diseases: Vol. 2 (pp. 359-371). Chichester: John Wiley & Sons

Müller, J.; Hemphill, A.; Müller, N. (2011). Treatment of giardiasis and drug resistance. In: Lujan, Hugo D.; Svärd, Staffan (eds.) Giardia - a model organism. Heidelberg: Springer Verlag

Muller, J.; Hemphill, A. (2011). Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs. Experimental parasitology, 128(2), pp. 145-50. Amsterdam: Elsevier 10.1016/j.exppara.2011.02.007

Muller, J.; Hemphill, A. (2011). Drug target identification in intracellular and extracellular protozoan parasites. Current topics in medicinal chemistry, 11(16), pp. 2029-38. Hilversum: Bentham Science Publishers 10.2174/156802611796575876

Pohle, S.; Ernst, R.; MacKenzie, C.; Spicher, M.; Romig, T.; Hemphill, A.; Gripp, S. (2011). Echinococcus multilocularis: the impact of ionizing radiation on metacestodes. Experimental parasitology, 127(1), pp. 127-34. Amsterdam: Elsevier 10.1016/j.exppara.2010.07.006

Stadelmann, B.; Kuster, T.; Scholl, S.; Barna, F.; Kropf, C.; Keiser, J.; Boykin, D.W.; Stephens, C.E.; Hemphill, A. (2011). In vitro efficacy of dicationic compounds and mefloquine enantiomers against Echinococcus multilocularis metacestodes. Antimicrobial agents and chemotherapy, 55(10), pp. 4866-72. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00478-11


Pachlatko, E.; Rusch, S.; Müller, A.; Hemphill, A.; Tilley, L.; Hanssen, E.; Beck, H.P. (2010). MAHRP2, an exported protein of Plasmodium falciparum, is an essential component of Maurer's cleft tethers. Molecular microbiology, 77(5), pp. 1136-1152. Oxford: Blackwell Science 10.1111/j.1365-2958.2010.07278.x

Debache, K.; Guionaud, C.; Alaeddine, F.; Hemphill, A. (2010). Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinant Neospora caninum antigens results in differential effects with regard to protection against experimental challenge with Neospora caninum tachyzoites. Parasitology, 137(2), pp. 229-40. London: Cambridge University Press 10.1017/S0031182009991259

Guionaud, C.; Hemphill, A.; Mevissen, M.; Alaeddine, F. (2010). Molecular characterization of Neospora caninum MAG1, a dense granule protein secreted into the parasitophorous vacuole, and associated with the cyst wall and the cyst matrix. Parasitology, 137(11), pp. 1605-19. London: Cambridge University Press 10.1017/S0031182010000442

Hemphill, A. (2010). Development and applications of cestode and trematode laboratory models. Parasitology, 137(3), pp. 329-33. London: Cambridge University Press 10.1017/S0031182010000132

Hemphill, A.; Stadelmann, B.; Scholl, S.; Muller, J.; Spiliotis, M.; Muller, N.; Gottstein, B.; Siles-Lucas, M. (2010). Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes. Parasitology, 137(3), pp. 569-87. London: Cambridge University Press 10.1017/S003118200999117X

Mejri, N.; Hemphill, A.; Gottstein, B. (2010). Triggering and modulation of the host-parasite interplay by Echinococcus multilocularis: a review. Parasitology, 137(3), pp. 557-68. London: Cambridge University Press 10.1017/S0031182009991533

Stadelmann, B.; Scholl, S.; Muller, J.; Hemphill, A. (2010). Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes. Journal of antimicrobial chemotherapy, 65(3), pp. 512-9. Oxford: Oxford University Press 10.1093/jac/dkp490

Stadelmann, B.; Spiliotis, M.; Muller, J.; Scholl, S.; Muller, N.; Gottstein, B.; Hemphill, A. (2010). Echinococcus multilocularis phosphoglucose isomerase (EmPGI): a glycolytic enzyme involved in metacestode growth and parasite-host cell interactions. International journal for parasitology, 40(13), pp. 1563-74. Kidlington, UK: Elsevier 10.1016/j.ijpara.2010.05.009


Vassella, Erik; Oberle, Michael; Urwyler, Simon; Renggli, Christina Kunz; Studer, Erwin; Hemphill, Andrew; Fragoso, Cristina; Bütikofer, Peter; Brun, Reto; Roditi, Isabel (2009). Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse. PLoS ONE, 4(2), e4493. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0004493

Debache, Karim; Alaeddine, Ferial; Guionaud, Christophe; Monney, Thierry; Müller, Joachim; Strohbusch, Maria; Leib, Stephen L.; Grandgirard, Denis; Hemphill, Andrew (2009). Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoites. International journal for parasitology, 39(12), pp. 1373-1384. Kidlington, UK: Elsevier 10.1016/j.ijpara.2009.04.006

Frey, Caroline; Schild, Marc; Hemphill, Andrew; Stünzi, Philipp; Müller, Norbert; Gottstein, Bruno; Burgener, Iwan (2009). Intestinal Tritrichomonas foetus infection in cats in Switzerland detected by in vitro cultivation and PCR. Parasitology research, 104(4), pp. 783-8. Berlin: Springer 10.1007/s00436-008-1255-2

Hemphill, Andrew; Vonlaufen, Nathalie; Golaz, Julia L; Burgener, Iwan (2009). Infection of primary canine duodenal epithelial cell cultures with Neospora caninum. Journal of parasitology, 95(2), pp. 372-80. Lawrence, Kans.: American Society of Parasitologists 10.1645/GE-1812.1

Gris, P.; Tighe, A.; Thawer, S.; Hemphill, A.; Oatway, M.; Weaver, L.; Dekaban, G.A.; Brown, A. (2009). Gene expression profiling in anti-CD11d mAb-treated spinal cord-injured rats. Journal of neuroimmunology, 209(1-2), pp. 104-13. Amsterdam: Elsevier 10.1016/j.jneuroim.2009.02.002

Hemphill, A.; Muller, J. (2009). Alveolar and cystic echinococcosis: towards novel chemotherapeutical treatment options. Journal of helminthology, 83(2), pp. 99-111. Cambridge: Cambridge University Press 10.1017/S0022149X0928936X

Hemphill, A.W.; Akkari, Y.; Newell, A.H.; Schultz, R.A.; Grompe, M.; North, P.S.; Hickson, I.D.; Jakobs, P.M.; Rennie, S.; Pauw, D.; Hejna, J.; Olson, S.B.; Moses, R.E. (2009). Topo IIIalpha and BLM act within the Fanconi anemia pathway in response to DNA-crosslinking agents. Cytogenetic and genome research, 125(3), pp. 165-75. Basel: Karger 10.1159/000230001

Muller, J.; Limban, C.; Stadelmann, B.; Missir, A.V.; Chirita, I.C.; Chifiriuc, M.C.; Nitulescu, G.M.; Hemphill, A. (2009). Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: a novel class of anti-parasitic compounds. Parasitology international, 58(2), pp. 128-35. Amsterdam: Elsevier 10.1016/j.parint.2008.12.003

Müller, Joachim; Nillius, Dorothea; Hehl, A.; Hemphill, Andrew; Müller, Norbert (2009). Stable expression of Escherichia coli beta-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testing. Journal of antimicrobial chemotherapy, 64(6), pp. 1187-1191. Oxford: Oxford University Press 10.1093/jac/dkp363

Schnyder, M.; Kohler, L.; Hemphill, A.; Deplazes, P. (2009). Prophylactic and therapeutic efficacy of nitazoxanide against Cryptosporidium parvum in experimentally challenged neonatal calves. Veterinary parasitology, 160(1-2), pp. 149-54. Amsterdam: Elsevier 10.1016/j.vetpar.2008.10.094

Strohbusch, M.; Muller, N.; Hemphill, A.; Krebber, R.; Greif, G.; Gottstein, B. (2009). Toltrazuril treatment of congenitally acquired Neospora caninum infection in newborn mice. Parasitology research, 104(6), pp. 1335-43. Berlin: Springer 10.1007/s00436-009-1328-x

Strohbusch, M.; Muller, N.; Hemphill, A.; Margos, M.; Grandgirard, D.; Leib, Stephen; Greif, G.; Gottstein, B. (2009). Neospora caninum and bone marrow-derived dendritic cells: parasite survival, proliferation, and induction of cytokine expression. Parasite immunology, 31(7), pp. 366-372. Oxford: Blackwell Scientific Publications 10.1111/j.1365-3024.2009.01112.x


Müller, Joachim; Ley, Serej; Felger, Ingrid; Hemphill, Andrew; Müller, Norbert (2008). Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole. Journal of antimicrobial chemotherapy, 62(1), pp. 72-82. Oxford University Press 10.1093/jac/dkn142

Müller, Joachim; Naguleswaran, Arunasalam; Müller, Norbert; Hemphill, Andrew (2008). Neospora caninum: functional inhibition of protein disulfide isomerase by the broad-spectrum anti-parasitic drug nitazoxanide and other thiazolides. Experimental parasitology, 118(1), pp. 80-8. Amsterdam: Elsevier 10.1016/j.exppara.2007.06.008

Spicher, Martin; Röthlisberger, Carole; Lany, C.; Lundström Stadelmann, Britta; Keiser, J.; Ortega-Mora, L. M.; Gottstein, Bruno; Hemphill, Andrew (2008). In Vitro and In Vivo Treatments of Echinococcus Protoscoleces and Metacestodes with Artemisinin and Artemisinin Derivatives. Antimicrobial agents and chemotherapy, 52(9), pp. 3447-3450. American Society for Microbiology 10.1128/AAC.00553-08


Oberholzer, Michael; Marti, Gabriela; Baresic, Mario; Kunz, Stefan; Hemphill, Andrew; Seebeck, Thomas (2007). The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence. FASEB journal, 21(3), pp. 720-731. Bethesda, Md.: Federation of American Societies for Experimental Biology 10.1096/fj.06-6818com

Esposito, Marco; Müller, Norbert; Hemphill, Andrew (2007). Structure-activity relationships from in vitro efficacies of the thiazolide series against the intracellular apicomplexan protozoan Neospora caninum. International journal for parasitology, 37(2), pp. 183-90. Kidlington, UK: Elsevier 10.1016/j.ijpara.2006.10.009

Hemphill, A (2007). Response to Innes and Mattsson: Neospora caninum emerges from the shadow of Toxoplasma gondii. Trends in parasitology, 2(23), pp. 44-5. Oxford: Elsevier Current Trends 10.1016/j.pt.2006.12.007

Sterk, Maaike; Müller, Joachim; Hemphill, Andrew; Müller, Norbert (2007). Characterization of a Giardia lamblia WB C6 clone resistant to the isoflavone formononetin. Microbiology, 153(Pt 12), pp. 4150-8. Reading, UK: Society for General Microbiology 10.1099/mic.0.2007/010041-0

Arsenijevic, D; de Bilbao, F; Vallet, P; Hemphill, A; Gottstein, B; Richard, D; Giannakopoulos, P; Langhans, W (2007). Decreased infarct size after focal cerebral ischemia in mice chronically infected with Toxoplasma gondii. Neuroscience, 150(3), pp. 537-46. Oxford: Elsevier 10.1016/j.neuroscience.2007.09.080

Hemphill, A; Spicher, M; Stadelmann, B; Mueller, J; Naguleswaran, A; Gottstein, B; Walker, M (2007). Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis. Parasitology, 134(Pt 12), pp. 1657-70. London: Cambridge University Press 10.1017/S0031182007003198

Golaz, Julia L; Vonlaufen, Nathalie; Hemphill, Andrew; Burgener, Iwan A (2007). Establishment and characterization of a primary canine duodenal epithelial cell culture. In vitro cellular & developmental biology - animal, 43(5-6), pp. 176-85. Columbia, Md.: Springer 10.1007/s11626-007-9034-4

Kaiser, Marcel; Wittlin, Sergio; Nehrbass-Stuedli, Angela; Dong, Yuxiang; Wang, Xiaofang; Hemphill, Andrew; Matile, Hugues; Brun, Reto; Vennerstrom, Jonathan L (2007). Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160). Antimicrobial agents and chemotherapy, 51(8), pp. 2991-3. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00225-07

Müller, Joachim; Sterk, Maaike; Hemphill, Andrew; Müller, Norbert (2007). Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole. Journal of antimicrobial chemotherapy, 60(2), pp. 280-7. Oxford: Oxford University Press 10.1093/jac/dkm205

Esposito, Marco; Moores, Shelley; Naguleswaran, Arunasalam; Müller, Joachim; Hemphill, Andrew (2007). Induction of tachyzoite egress from cells infected with the protozoan Neospora caninum by nitro- and bromo-thiazolides, a class of broad-spectrum anti-parasitic drugs. International journal for parasitology, 37(10), pp. 1143-52. Kidlington, UK: Elsevier 10.1016/j.ijpara.2007.03.007

Müller, Joachim; Wastling, Jonathan; Sanderson, Sanya; Müller, Norbert; Hemphill, Andrew (2007). A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides. Antimicrobial agents and chemotherapy, 51(6), pp. 1979-86. Washington, D.C.: American Society for Microbiology 10.1128/AAC.01548-06

Cortes, Helder C E; Reis, Yara; Gottstein, Bruno; Hemphill, Andrew; Leitão, Alexandre; Müller, Norbert (2007). Application of conventional and real-time fluorescent ITS1 rDNA PCR for detection of Besnoitia besnoiti infections in bovine skin biopsies. Veterinary parasitology, 146(3-4), pp. 352-6. Amsterdam: Elsevier 10.1016/j.vetpar.2007.03.003

Risco-Castillo, V; Fernández-García, A; Zaballos, A; Aguado-Martínez, A; Hemphill, A; Rodríguez-Bertos, A; Alvarez-García, G; Ortega-Mora, L M (2007). Molecular characterisation of BSR4, a novel bradyzoite-specific gene from Neospora caninum. International journal for parasitology, 37(8-9), pp. 887-96. Kidlington, UK: Elsevier 10.1016/j.ijpara.2007.02.003

Cortes, H C E; Mueller, N; Esposito, M; Leitão, A; Naguleswaran, A; Hemphill, A (2007). In vitro efficacy of nitro- and bromo-thiazolyl-salicylamide compounds (thiazolides) against Besnoitia besnoiti infection in Vero cells. Parasitology, 134(Pt 7), pp. 975-85. London: Cambridge University Press 10.1017/S0031182007002417

Vonlaufen, N; Naguleswaran, A; Gianinazzi, C; Hemphill, A (2007). Characterization of the fetuin-binding fraction of Neospora caninum tachyzoites and its potential involvement in host-parasite interactions. Parasitology, 134(Pt 6), pp. 805-17. London: Cambridge University Press 10.1017/S0031182006002186

Srinivasan, Sangeetha; Mueller, Joachim; Suana, Angela; Hemphill, Andrew (2007). Vaccination with microneme protein NcMIC4 increases mortality in mice inoculated with Neospora caninum. Journal of parasitology, 93(5), pp. 1046-55. Lawrence, Kans.: American Society of Parasitologists 10.1645/GE-1181R1.1

Hemphill, A; Müller, N; Müller, J (2007). Structure-funktion relationship of thiazolides, a novel class of antiparasitic drugs, investigated in intracellular protozoan parasites and larvalstage cestodes. Anti-infective agents in medicinal chemistry(6), pp. 273-282. Sharjah: Bentham Science

Hemphill, A (2007). Generation of parasite cysts in cultured cells instead of living animals. Parasitology(24), pp. 29-31. London: Cambridge University Press


Naguleswaran, Arunasalam; Spicher, Martin; Vonlaufen, Nathalie; Ortega-Mora, Luis M; Torgerson, Paul; Gottstein, Bruno; Hemphill, Andrew (2006). In vitro metacestodicidal activities of genistein and other isoflavones against Echinococcus multilocularis and Echinococcus granulosus. Antimicrobial agents and chemotherapy, 50(11), pp. 3770-8. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00578-06

Matsumoto, J; Müller, N; Hemphill, A; Oku, Y; Kamiya, M; Gottstein, B (2006). 14-3-3- and II/3-10-gene expression as molecular markers to address viability and growth activity of Echinococcus multilocularis metacestodes. Parasitology, 132(Pt 1), pp. 83-94. London: Cambridge University Press 10.1017/S0031182005008632

Srinivasan, Sangeetha; Baszler, Timothy; Vonlaufen, Nathalie; Leepin, Angela; Sanderson, Sanya J; Wastling, Jonathan M; Hemphill, Andrew (2006). Monoclonal antibody directed against Neospora caninum tachyzoite carbohydrate epitope reacts specifically with apical complex-associated sialylated beta tubulin. Journal of parasitology, 92(6), pp. 1235-43. Lawrence, Kans.: American Society of Parasitologists 10.1645/GE-889R.1

Cortes, H C E; Reis, Y; Waap, H; Vidal, R; Soares, H; Marques, I; Pereira da Fonseca, I; Fazendeiro, I; Ferreira, M L; Caeiro, V; Shkap, V; Hemphill, A; Leitão, A (2006). Isolation of Besnoitia besnoiti from infected cattle in Portugal. Veterinary parasitology, 141(3-4), pp. 226-33. Amsterdam: Elsevier 10.1016/j.vetpar.2006.05.022

Müller, Joachim; Rühle, Géraldine; Müller, Norbert; Rossignol, Jean-François; Hemphill, Andrew (2006). In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells. Antimicrobial agents and chemotherapy, 50(1), pp. 162-70. Washington, D.C.: American Society for Microbiology 10.1128/AAC.50.1.162-170.2006

Gottstein, Bruno; Haag, Karen; Walker, Mirjam; Matsumoto, Jun; Mejri, Naceur; Hemphill, Andrew (2006). Molecular survival strategies of Echinococcus multilocularis in the murine host. Parasitology international, 55 Suppl, S45-S49. Amsterdam: Elsevier 10.1016/j.parint.2005.11.006

Hemphill, Andrew; Mueller, Joachim; Esposito, Marco (2006). Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections. Expert opinion on pharmacotherapy, 7(7), pp. 953-64. London: Informa Healthcare 10.1517/14656566.7.7.953

Hehl, A B; Hemphill, A (2006). The use of light- and electron microscopy for studies on the cell- and molecular biology of parasites and parasitic diseases. Schweizer Archiv für Tierheilkunde, 148(9), pp. 473-81. Bern: Huber 10.1024/0036-7281.148.9.473

Hemphill, A; Vonlaufen, N; Naguleswaran, A (2006). Cellular and immunological basis of the host-parasite relationship during infection with Neospora caninum. Parasitology, 133(Pt 3), pp. 261-78. London: Cambridge University Press 10.1017/S0031182006000485

Hemphill, A; Gottstein, B (2006). Neospora caninum and neosporosis - recent achievements in host and parasite cell biology and treatment. Acta parasitologica, 51(1), pp. 15-25. Warszawa: Versita 10.2478/s11686-006-0002-z


Scheidegger, Alexandra; Vonlaufen, Nathalie Françoise F.; Naguleswaran, Arunasalam; Gianinazzi, Christian; Müller, Norbert; Leib, Stephen; Hemphill, Andrew (2005). Differential effects of interferon-gamma and tumor necrosis factor-alpha on Toxoplasma gondii proliferation in organotypic rat brain slice cultures. The Journal of parasitology, 91(2), pp. 307-315. 10.1645/GE-379R

von Allmen, N; Bienz, M; Hemphill, Andrew; Müller, Norbert (2005). Quantitative assessment of sense and antisense transcripts from genes involved in antigenic variation (vsp genes) and encystation (cwp 1 gene) of Giardia lamblia clone GS/M-83-H7. Parasitology, 130(Pt 4), pp. 389-396. Cambridge University Press


von Allmen, N; Bienz, M; Hemphill, Andrew; Müller, Norbert (2004). Experimental infections of neonatal mice with cysts of Giardia lamblia clone GS/M-83-H7 are associated with an antigenic reset of the parasite. Infection and immunity, 72(8), pp. 4763-4771. American Society for Microbiology 10.1128/IAI.72.8.4763-4771.2004

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