Hunziker, Ernst Bruno

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2016

Hunziker, Ernst Bruno; Jovanovic, J; Horner, A; Keel, Marius; Lippuner, Kurt; Shintani, Nahoko (2016). Optimisation of BMP-2 dosage for the osseointegration of porous titanium implants in an ovine model. European cells & materials eCM, 32, pp. 241-256. University of Wales 10.22203/eCM.v032a16

Boushell, Margaret K; Hung, Clark T; Hunziker, Ernst Bruno; Strauss, Eric J; Lu, Helen H (2016). Current strategies for integrative cartilage repair. Connective tissue research, pp. 1-14. Taylor & Francis 10.1080/03008207.2016.1231180

Hunziker, Ernst Bruno; Lippuner, Kurt; Keel, Marius J. B.; Shintani, Nahoko (2016). A novel organ-slice culturing system to simulate meniscal repair: Proof of concept using a synovium-based pool of meniscoprogenitor cells. Journal of orthopaedic research, 34(9), pp. 1588-1596. Wiley 10.1002/jor.23172

2015

Hunziker, Ernst Bruno; Lippuner, Kurt; Keel, Marius; Shintani, Nahoko (2015). Age-Independent Cartilage Generation for Synovium-Based Autologous Chondrocyte Implantation. Tissue engineering. Part A, 21(13-14), pp. 2089-2098. Mary Ann Liebert 10.1089/ten.TEA.2014.0599

Hunziker, Ernst Bruno; Lippuner, Kurt; Keel, Marius; Shintani, Nahoko (2015). An educational review of cartilage repair: precepts & practice - myths & misconceptions - progress & prospects. Osteoarthritis and cartilage, 23(3), pp. 334-350. Elsevier 10.1016/j.joca.2014.12.011

Niebler, Stephan; Schubert, Thomas; Hunziker, Ernst Bruno; Bosserhoff, Anja K (2015). Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development. Arthritis research & therapy, 17(119), p. 119. BioMed Central 10.1186/s13075-015-0648-8

2014

Hunziker, Ernst Bruno; Lippuner, Kurt; Shintani, Nahoko (2014). How best to preserve and reveal the structural intricacies of cartilaginous tissue. Matrix biology, 39, pp. 33-43. Elsevier 10.1016/j.matbio.2014.08.010

2013

Quinn, T. M.; Häuselmann, H.-J.; Shintani, N.; Hunziker, Ernst Bruno (2013). Cell and matrix morphology in articular cartilage from adult human knee and ankle joints suggests depth-associated adaptations to biomechanical and anatomical roles. OSTEOARTHRITIS AND CARTILAGE, 21(12), pp. 1904-1912. Elsevier 10.1016/j.joca.2013.09.011

Hall-Glenn, Faith; Aivazi, Armen; Akopyan, Lusi; Ong, Jessica R.; Baxter, Ruth R.; Benya, Paul D.; Goldschmeding, Roel; van Nieuwenhoven, Frans A.; Hunziker, Ernst B.; Lyons, Karen M. (2013). CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress. Journal of cell communication and signaling, 7(3), pp. 219-30. Springer 10.1007/s12079-013-0201-y

Byun, Sangwon; Sinskey, Yunna L; Lu, Yihong C S; Ort, Tatiana; Kavalkovich, Karl; Sivakumar, Pitchumani; Hunziker, Ernst Bruno; Frank, Eliot H; Grodzinsky, Alan J (2013). Transport of anti-IL-6 antigen binding fragments into cartilage and the effects of injury. Archives of biochemistry and biophysics, 532(1), pp. 15-22. Elsevier 10.1016/j.abb.2012.12.020

Hofstetter, Wilhelm; Sehr, Harald; De Wild, Michael; Portenier, Jeannette; Gobrecht, Jens; Hunziker, Ernst Bruno (2013). Modulation of human osteoblasts by metal surface chemistry. Journal of biomedical materials research. Part A, 101(8), pp. 2355-2364. Hoboken, N.J.: John Wiley & Sons 10.1002/jbm.a.34541

Shintani, Nahoko; Siebenrock, Klaus-Arno; Hunziker, Ernst Bruno (2013). TGF-ß1 enhances the BMP-2-induced chondrogenesis of bovine synovial explants and arrests downstream differentiation at an early stage of hypertrophy. PLoS ONE, 8(1), e53086. Public Library of Science 10.1371/journal.pone.0053086

2012

Hunziker, E B; Enggist, L; Küffer, A; Buser, D; Liu, Y (2012). Osseointegration: the slow delivery of BMP-2 enhances osteoinductivity. Bone, 51(1), pp. 98-106. New York, N.Y.: Elsevier 10.1016/j.bone.2012.04.004

2011

Broggini, N; Hofstetter, W; Hunziker, E; Bosshardt, DD; Bornstein, MM; Seto, I; Weibrich, G; Buser, D (2011). The Influence of PRP on Early Bone Formation in Membrane Protected Defects. A Histological and Histomorphometric Study in the Rabbit Calvaria. Clinical implant dentistry and related research, 13(1), pp. 1-12. Oxford: Blackwell 10.1111/j.1708-8208.2009.00266.x

Shintani, N; Hunziker, E B (2011). Differential effects of dexamethasone on the chondrogenesis of mesenchymal stromal cells: influence of microenvironment, tissue origin and growth factor. European cells & materials eCM, 22, pp. 302-319. Aberystwyth (UK): University of Wales

Wu, Gang; Hunziker, Ernst B; Zheng, Yuanna; Wismeijer, Daniel; Liu, Yuelian (2011). Functionalization of deproteinized bovine bone with a coating-incorporated depot of BMP-2 renders the material efficiently osteoinductive and suppresses foreign-body reactivity. Bone, 49(6), pp. 1323-30. New York, N.Y.: Elsevier 10.1016/j.bone.2011.09.046

Wang, Susanne X; Arsenault, Larry; Hunziker, Ernst B (2011). Stereologic analysis of tibial-plateau cartilage and femoral cancellous bone in guinea pigs with spontaneous osteoarthritis. Clinical orthopaedics and related research, 469(10), pp. 2796-805. Heidelberg: Springer 10.1007/s11999-011-1899-6

Ferri, J; Hunziker, EB (2011). Preprosthetic and maxillofacial surgery: Biomaterials, bone grafting and tissue engineering. Cambridge, UK: Woodhead Publishing

Ferri, J; Hunziker, EB (2011). Preprostehtic and maxillofacial surgery. Cambridge, UK: Woodhead Publishing Ltd.

Hunziker, EB (2011). Osteoindctivization of dental implants and bone- defect-filling materials. In: Ferri J, Hunziker EB (ed.) Preprosthetic and maxillofacial surgery (pp. 327-333). Cambridge, UK: Woodhead Publishing Ltd.

2010

Wernike, E; Montjovent, MO; Liu, Y; Wismeijer, D; Hunziker, EB; Siebenrock, KA; Hofstetter, W; Klenke, FM (2010). VEGF incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in vivo. European cells & materials eCM, 19, pp. 30-40. Aberystwyth (UK): University of Wales

Wu, Gang; Liu, Yuelian; Iizuka, Tateyuki; Hunziker, Ernst B (2010). Biomimetic coating of organic polymers with a protein-functionalized layer of calcium phosphate: the surface properties of the carrier influence neither the coating characteristics nor the incorporation mechanism or release kinetics of the protein. Tissue engineering. Part C - methods, 16(6), pp. 1255-65. New Rochelle, N.Y.: Mary Ann Liebert 10.1089/ten.tec.2009.0588

Wernike, E; Hofstetter, W; Liu, Y; Wu, G; Sebald, HJ; Wismeijer, D; Hunziker, EB; Siebenrock, KA; Klenke, FM (2010). Long-term cell-mediated protein release from calcium phosphate ceramics. Journal of biomedical materials research, 92(2), pp. 463-74. Hoboken, N.J.: John Wiley & Sons 10.1002/jbm.a.32411

Hägi, Tobias T; Enggist, Lukas; Michel, Daniel; Ferguson, Stephen J; Liu, Yuelian; Hunziker, Ernst B (2010). Mechanical insertion properties of calcium-phosphate implant coatings. Clinical oral implants research, 21(11), pp. 1214-1222. Oxford: Wiley-Blackwell 10.1111/j.1600-0501.2010.01916.x

Wu, Gang; Liu, Yuelian; Iizuka, Tateyuki; Hunziker, Ernst Bruno (2010). The effect of a slow mode of BMP-2 delivery on the inflammatory response provoked by bone-defect-filling polymeric scaffolds. Biomaterials, 31(29), pp. 7485-93. Oxford: Elsevier 10.1016/j.biomaterials.2010.06.037

Hägi, TT; Wu, G; Liu, Y; Hunziker, EB (2010). Cell-mediated BMP-2 liberation promotes bone formation in a mechanically unstable implant environment. Bone, 46(5), pp. 1322-1327. New York, N.Y.: Elsevier 10.1016/j.bone.2010.02.010

Lavverty, S; Girard, CA; Williams, JM; Hunziker, EB; Pritzker, KPH¶ (2010). The OARSI histopathology initiative recommendations for histological assessments of osteoarthritis in the rabbit. Osteoarthritis and cartilage, 18(3), pp. 53-65. Amsterdam: Elsevier 10.1016/j.joca.2010.05.029

Pastoureau, PC; Hunziker, EB; Pelletier, JP (2010). Cartilage, bone and synovial histomorphometry in animal models of osteoarthritis. Osteoarthritis and cartilage, 18(3), pp. 106-112. Amsterdam: Elsevier 10.1016/j.joca.2010.05.024

Hunziker, EB (2010). The structure of articular cartilage. In: Archer C, Ralphs J (ed.) Regenerative medicine and biomaterials for the repair of connective tissues. Cambridge UK: Woodhead Publishing Limited

2009

Liu, Yuelian; Hunziker, Ernst Bruno (2009). Biomimetic Coatings and Their Biological Functionalization. In: León, Betty; Jansen, John (eds.) Thin Calcium Phosphate Coatings for Medical Implants (pp. 301-314). New York: Springer Verlag 10.1007/978-0-387-77718-4_11

Raducanu, Aurelia; Hunziker, Ernst B; Drosse, Inga; Aszódi, Attila (2009). Beta1 integrin deficiency results in multiple abnormalities of the knee joint. Journal of biological chemistry, 284(35), pp. 23780-92. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M109.039347

Hunziker, EB (2009). The elusive path to cartilage regeneration. Advanced materials, 2009(21), pp. 3419-3424. Weinheim: Wiley-VCH 10.1002/adma.200801957

Liu, Y; de Groot, K; Hunziker, EB (2009). Biomimetic mineral coatings in dental and orthopaedic implantology. Frontiers of materials science in China, 2009(3 (2)), pp. 154-162. Beijing: SP Higher Education Press

2008

Klenke, FM; Liu, Y; Yuan, H; Hunziker, EB; Siebenrock, KA; Hofstetter, W (2008). Impact of pore size on the vascularization and osseointegration of ceramic bone substitutes in vivo. Journal of biomedical materials research. Part A, 85(3), pp. 777-86. Hoboken, N.J.: John Wiley & Sons 10.1002/jbm.a.31559

Sun, Tiezheng; Hunziker, Ernst B; Morales, Teresa I (2008). Subcellular distribution of the insulin-like growth factor (IGF) binding proteins (IGFBPs) 2 and 3 in articular chondrocytes. Journal of orthopaedic research, 26(11), pp. 1421-7. Hoboken, N.J.: Wiley 10.1002/jor.20660

Hunziker, E B; Stähli, A (2008). Surgical suturing of articular cartilage induces osteoarthritis-like changes. Osteoarthritis and cartilage, 16(9), pp. 1067-73. Amsterdam: Elsevier 10.1016/j.joca.2008.01.009

Mikic, Borjana; Ferreira, Maria P; Battaglia, Todd C; Hunziker, Ernst B (2008). Accelerated hypertrophic chondrocyte kinetics in GDF-7 deficient murine tibial growth plates. Journal of orthopaedic research, 26(7), pp. 986-90. Hoboken, N.J.: Wiley 10.1002/jor.20574

Hunziker, E B; Kapfinger, E; Martin, J; Buckwalter, J; Morales, T I (2008). Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) is closely associated with the chondrocyte nucleus in human articular cartilage. Osteoarthritis and cartilage, 16(2), pp. 185-94. Amsterdam: Elsevier 10.1016/j.joca.2007.06.008

2007

Hunziker, E B; Kapfinger, E; Geiss, J (2007). The structural architecture of adult mammalian articular cartilage evolves by a synchronized process of tissue resorption and neoformation during postnatal development. Osteoarthritis and cartilage, 15(4), 403 - 413. Amsterdam: Elsevier 10.1016/j.joca.2006.09.010

Storgard, Simon Jensen; Yeo, Alvin; Dard, Michel; Hunziker, Ernst Bruno; Schenk, Robert Konrad; Buser, Daniel (2007). Evaluation of a novel biphasic calcium phosphate in standardized bone defects: a histologic and histomorphometric study in the mandibles of minipigs. Clinical oral implants research, 18(6), pp. 752-760. Oxford: Wiley-Blackwell 10.1111/j.1600-0501.2007.01417.x

Liu, Yuelian; Enggist, Lukas; Küffer, Alexander Friedrich; Buser, Daniel; Hunziker, Ernst Bruno (2007). The influence of BMP-2 and its mode of delivery on the osteoconductivity of implant surfaces during the early phase of osseointegration. Biomaterials, 28(16), pp. 2677-2686. Oxford: Elsevier 10.1016/j.biomaterials.2007.02.003

Liu, Yuelian; Huse, Robert O; de Groot, Klaas; Buser, Daniel; Hunziker, Ernst Bruno (2007). Delivery mode and efficacy of BMP-2 in association with implants. Journal of dental research, 86(1), pp. 84-89. Thousand Oaks, Calif.: Sage 10.1177/154405910708600114

Nicolae, Claudia; Ko, Ya-Ping; Miosge, Nicolai; Niehoff, Anja; Studer, Daniel; Enggist, Lukas; Hunziker, Ernst B; Paulsson, Mats; Wagener, Raimund; Aszodi, Attila (2007). Abnormal collagen fibrils in cartilage of matrilin-1/matrilin-3-deficient mice. Journal of biological chemistry, 282(30), pp. 22163-75. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M610994200

Hunziker, Ernst B (2007). Cartilage histomorphometry. Methods in molecular medicine, 135, pp. 147-166. Totowa, N.J.: Humana Press

Shintani, Nahoko; Hunziker, Ernst B (2007). Chondrogenic differentiation of bovine synovium: bone morphogenetic proteins 2 and 7 and transforming growth factor beta1 induce the formation of different types of cartilaginous tissue. Arthritis & rheumatism, 56(6), pp. 1869-79. Hoboken, N.J.: Wiley-Blackwell 10.1002/art.22701

Kurth, T; Hedbom, E; Shintani, N; Sugimoto, M; Chen, F H; Haspl, M; Martinovic, S; Hunziker, E B (2007). Chondrogenic potential of human synovial mesenchymal stem cells in alginate. Osteoarthritis and cartilage, 15(10), pp. 1178-89. Amsterdam: Elsevier 10.1016/j.joca.2007.03.015

Shintani, Nahoko; Kurth, Tobias; Hunziker, Ernst B (2007). Expression of cartilage-related genes in bovine synovial tissue. Journal of orthopaedic research, 25(6), pp. 813-9. Hoboken, N.J.: Wiley 10.1002/jor.20345

Patra, Debabrata; Xing, Xiaoyun; Davies, Sherri; Bryan, Jennifer; Franz, Carl; Hunziker, Ernst B; Sandell, Linda J (2007). Site-1 protease is essential for endochondral bone formation in mice. Journal of cell biology, 179(4), pp. 687-700. New York, N.Y.: Rockefeller Institute Press 10.1083/jcb.200708092

Tsang, Kwok Yeung; Chan, Danny; Cheslett, Deborah; Chan, Wilson C W; So, Chi Leong; Melhado, Ian G; Chan, Tori W Y; Kwan, Kin Ming; Hunziker, Ernst B; Yamada, Yoshihiko; Bateman, John F; Cheung, Kenneth M C; Cheah, Kathryn S E (2007). Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function. PLoS biology, 5(3), e44. Lawrence, Kans.: Public Library of Science 10.1371/journal.pbio.0050044

2006

Hunziker, E; Spector, M; Libera, J; Gertzman, A; Woo, SL; Ratcliffe, A; Lysaght, M; Coury, A; Kaplan, D; Vunjak-Novakovic, G (2006). Translation from research to applications. Tissue engineering, 12(12), pp. 3341-64. Larchmont, N.Y.: Mary Ann Liebert 10.1089/ten.2006.12.3341

Liu, Y; Huse, R O; de Groot, K; Buser, D; Hunziker, E B (2006). Quantitative evaluation/comparison of the osteoconductivity of BMP-2 by 4 different delivery modes in a rat extopic model. Bioceramics

2005

Moretti, M; Wendt, D; Schaefer, D; Jakob, M; Hunziker, E B; Heberer, M; Martin, I (2005). Structural characterization and reliable biomechanical assessment of integrative cartilage repair. Journal of biomechanics, 38(9), pp. 1846-54. New York, N.Y.: Elsevier 10.1016/j.jbiomech.2004.08.021

Quinn, Thomas M; Hunziker, Ernst B; Häuselmann, Hans-Jörg (2005). Variation of cell and matrix morphologies in articular cartilage among locations in the adult human knee. Osteoarthritis and cartilage, 13(8), pp. 672-8. Amsterdam: Elsevier 10.1016/j.joca.2005.04.011

Park, Y; Sugimoto, M; Watrin, A; Chiquet, M; Hunziker, E B (2005). BMP-2 induces the expression of chondrocyte-specific genes in bovine synovium-derived progenitor cells cultured in three-dimensional alginate hydrogel. Osteoarthritis and cartilage, 13(6), pp. 527-36. Amsterdam: Elsevier 10.1016/j.joca.2005.02.006

Liu, Y; de Groot, K; Hunziker, E B (2005). BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model. Bone, 36(5), pp. 745-57. New York, N.Y.: Elsevier 10.1016/j.bone.2005.02.005

Liu, Y M; de Groot, K; Hunziker, E B (2005). Cell-mediated protein release from calcium-phosphate-coated titanium implants. Journal of controlled release, 101(1-3), pp. 346-7. Amsterdam: Elsevier

Bengtsson, Therese; Aszodi, Attila; Nicolae, Claudia; Hunziker, Ernst B; Lundgren-Akerlund, Evy; Fässler, Reinhard (2005). Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. Journal of cell science, 118(Pt 5), pp. 929-36. Cambridge: Company of Biologists Limited 10.1242/jcs.01678

Docheva, Denitsa; Hunziker, Ernst B; Fässler, Reinhard; Brandau, Oliver (2005). Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Molecular and cellular biology, 25(2), pp. 699-705. Washington, D.C.: American Society for Microbiology 10.1128/MCB.25.2.699-705.2005

2004

Szafranski, Jon D; Grodzinsky, Alan J; Burger, Elke; Gaschen, Veronique; Hung, Han-Hwa; Hunziker, Ernst B (2004). Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis. Osteoarthritis and cartilage, 12(12), pp. 937-46. Amsterdam: Elsevier 10.1016/j.joca.2004.08.004

Park, Yongdoo; Lutolf, Matthias P; Hubbell, Jeffrey A; Hunziker, Ernst B; Wong, Marcy (2004). Bovine primary chondrocyte culture in synthetic matrix metalloproteinase-sensitive poly(ethylene glycol)-based hydrogels as a scaffold for cartilage repair. Tissue engineering, 10(3-4), pp. 515-22. Larchmont, N.Y.: Mary Ann Liebert 10.1089/107632704323061870

Mikic, B; Clark, R T; Battaglia, T C; Gaschen, V; Hunziker, E B (2004). Altered hypertrophic chondrocyte kinetics in GDF-5 deficient murine tibial growth plates. Journal of orthopaedic research, 22(3), pp. 552-6. Hoboken, N.J.: Wiley 10.1016/j.orthres.2003.09.002

Liu, Y; de Groot, K; Hunziker, E B (2004). Osteoinductive implants: the mise-en-scène for drug-bearing biomimetic coatings. Annals of biomedical engineering, 32(3), pp. 398-406. Cambridge: Springer 10.1023/B:ABME.0000017536.10767.0f

Liu, Yuelian; Hunziker, Ernst B; Layrolle, Pierre; De Bruijn, Joost D; De Groot, Klaas (2004). Bone morphogenetic protein 2 incorporated into biomimetic coatings retains its biological activity. Tissue engineering, 10(1-2), pp. 101-8. Larchmont, N.Y.: Mary Ann Liebert 10.1089/107632704322791745

Patwari, P; Gaschen, V; James, I E; Berger, E; Blake, S M; Lark, M W; Grodzinsky, A J; Hunziker, E B (2004). Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage. Osteoarthritis and cartilage, 12(3), pp. 245-52. Amsterdam: Elsevier 10.1016/j.joca.2003.11.004

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