Lochner, Martin

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2017

Ruepp, Marc-David; Wei, Hao; Leuenberger, Michele; Lochner, Martin; Thompson, Andrew James (2017). The binding orientation of structurally-related ligands can differ; A cautionary note (In Press). Neuropharmacology Elsevier 10.1016/j.neuropharm.2017.01.023

Thompson, Andrew J.; Metzger, Simon; Lochner, Martin; Ruepp, Marc-David (2017). The binding orientation of epibatidine at α7 nACh receptors. Neuropharmacology, 116, pp. 421-428. Elsevier 10.1016/j.neuropharm.2017.01.008

2016

Mu, Linjing; Müller Herde, Adrienne; Rüefli, Pascal; Sladojevich, Filippo; Sephton, Selena Milicevic; Krämer, Stefanie D.; Thompson, Andrew James; Schibli, Roger; Ametamey, Simon M.; Lochner, Martin (2016). Synthesis and Pharmacological Evaluation of [11C]granisetron and [18F]fluoropalonosetron as PET Probes for 5-HT3 Receptor Imaging. ACS chemical neuroscience, 7(11), pp. 1552-1564. American Chemical Society 10.1021/acschemneuro.6b00192

Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Leuenberger, Michele; Rüefli, Pascal; Bur-Cecilio Hechavarria, Yamileidi; Ruepp, Marc-David; Thompson, Andrew J. (August 2016). Investigation of the interaction between 5-HT3R and its modulators: progress in understanding the agonist binding site. CHIMIA, 70(7/8), MC121. Schweizerische Chemische Gesellschaft

Lochner, Martin; Thompson, Andrew James (2016). The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5-HT3 receptors. Neuropharmacology, 108, pp. 220-228. Elsevier 10.1016/j.neuropharm.2016.04.027

Leuenberger, Michele; Ritler, Andreas; Simonin, Alexandre; Hediger, Matthias; Lochner, Martin (2016). Concise Asymmetric Synthesis and Pharmacological Characterization of All Stereoisomers of Glutamate Transporter Inhibitor TFB-TBOA and Synthesis of EAAT Photoaffinity Probes. ACS chemical neuroscience, 7(5), pp. 534-539. American Chemical Society 10.1021/acschemneuro.5b00311

Knight, Anthony; Hemmings, Jennifer Luise; Winfield, Ian; Leuenberger, Michele; Frattini, Eugenia; Frenguelli, Bruno G.; Dowell, Simon J.; Lochner, Martin; Ladds, Graham (2016). Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity. Journal of medicinal chemistry, 59(3), pp. 947-964. American Chemical Society 10.1021/acs.jmedchem.5b01402

2015

Lochner, Martin; Thompson, Andrew James (2015). Lighting up neuroscience. Neuropharmacology, 98, pp. 1-2. Elsevier 10.1016/j.neuropharm.2015.10.004

Lochner, Martin; Thompson, Andrew J. (eds.) (2015). Fluorescent Tools in Neuropharmacology. Special Issue of Neuropharmacology, 98. Elsevier

Hemmings, Jennifer Luise; Lochner, Martin (August 2015). Development of small molecular tools for the cellular study of adenosine A1 receptors. CHIMIA, 69(7/8), p. 467. Schweizerische Chemische Gesellschaft

Simonin, Jonathan; Lochner, Martin (August 2015). Fluorescent probes for the cellular study of the 5-HT3A receptor - synthesis and evaluation of near-infrared probes. CHIMIA, 69(7/8), p. 467. Schweizerische Chemische Gesellschaft

Jack, Thomas; Lochner, Martin (August 2015). Synthesis of photo-crosslinking probes and their application for the site-selective chemical modification of the 5-HT3 receptor. CHIMIA, 69(7/8), p. 468. Schweizerische Chemische Gesellschaft

Lochner, Martin; Hemmings, Jennifer Luise; Knight, Anthony; Frenguelli, Bruno G.; Ladds, Graham (15 June 2015). Development of small molecular tools for the cellular study of adenosine receptors (Unpublished). In: Challenges in Chemical Biology (ISACS16). ETH Zürich, Hönggerberg, Switzerland. 15.06.-18.06.2015.

Leuenberger, Michele; Jack, Thomas; Ruepp, Marc-David; Lagache, Sophie; Heller, Manfred; Mühlemann, Oliver; Thompson, Andrew J.; Lochner, Martin (15 June 2015). Synthesis of photo-crosslinking probes and their application for the site-selective chemical modification of the 5-HT3 receptor (Unpublished). In: Challenges in Chemical Biology (ISACS16). Book of Abstracts. ETH Zürich, Hönggerberg, Switzerland. 15.06.-18.06.2015.

Barden, Adam O.; Goler, Adam S.; Humphreys, Sara C.; Tabatabaei, Samaneh; Lochner, Martin; Ruepp, Marc-David; Jack, Thomas; Simonin, Jonathan; Thompson, Andrew James; Jones, Jeffrey P.; Brozik, James A. (2015). Tracking individual membrane proteins and their biochemistry: The power of direct observation. Neuropharmacology, 98, pp. 22-30. Elsevier 10.1016/j.neuropharm.2015.05.003

Lochner, Martin; Thompson, Andrew James (2015). A review of fluorescent ligands for studying 5-HT3 receptors. Neuropharmacology, 98, pp. 31-40. Elsevier 10.1016/j.neuropharm.2015.04.002

Jack, Thomas; Simonin, Jonathan; Ruepp, Marc-David; Thompson, Andrew James; Gertsch, Jürg; Lochner, Martin (2015). Characterizing New Fluorescent Tools for Studying 5-HT3 Receptor Pharmacology. Neuropharmacology, 90, pp. 63-73. Elsevier 10.1016/j.neuropharm.2014.11.007

2014

Lochner, Martin; Thompson, Andrew James (2014). The Antimalarial Drug Proguanil Is An Antagonist at 5-HT3 Receptors. Journal of pharmacology and experimental therapeutics, 351(3), pp. 674-684. American Society for Pharmacology and Experimental Therapeutics 10.1124/jpet.114.218461

Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Ruepp, Marc-David; Leuenberger, Michele; Hemmings, Jennifer Luise; Singhanat, Suradech; Thompson, Andrew James (2 October 2014). Studying Ion Channels and Receptors Using Synthetic Molecular Probes (Unpublished). In: 3rd Swiss-Japanese Chemical Biology Symposium. Bern, Switzerland. 02.-03.10.2014.

Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Singhanat, Suradech; Leuenberger, Michele; Ruepp, Marc-David; Hemmings, Jennifer Luise; Thompson, Andrew James (20 August 2014). Synthesis of Molecular Tools for the Cellular Study of Ion Channels and Receptors (Unpublished). In: EMBO Conference Chemical Biology. Heidelberg, Germany. 20.-23.08.2014.

Jack, Thomas; Lochner, Martin (August 2014). Site-selective chemical modification of the 5-HT3 receptor with newly developed photo-crosslinking probes. CHIMIA, 68(7/8), p. 552. Schweizerische Chemische Gesellschaft

Leuenberger, Michele; Lochner, Martin (August 2014). Synthesis of inhibitors and probes for the cellular study of glutamate transporters. CHIMIA, 68(7/8), p. 552. Schweizerische Chemische Gesellschaft

Simonin, Jonathan; Lochner, Martin (August 2014). Fluorescent probes for the cellular study of the 5-HT3A receptor - development of binding assay and in-vivo imaging. CHIMIA, 68(7/8), p. 553. Schweizerische Chemische Gesellschaft

Hemmings, Jennifer Luise; Lochner, Martin (July 2014). Novel fluorescent agonists for the A1 adenosine receptor. CHIMIA, 68(7/8), p. 552. Schweizerische Chemische Gesellschaft

Jack, Thomas; Ruepp, Marc-David; Thompson, Andrew J.; Mühlemann, Oliver; Lochner, Martin (2014). Synthesis and Characterization of Photoaffinity Probes that Target the 5-HT<SUB>3</SUB> Receptor. CHIMIA, 68(4), pp. 239-242. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2014.239

Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Leuenberger, Michele; Hemmings, Jennifer Luise; Singhanat, Suradech (24 January 2014). Toolomics - Molecular Probes for Studying and Modification of Ion Channels and Receptors (Unpublished). In: 12th Swiss Snow Symposium. Saas-Fee, Switzerland. 24.01.2014.

2013

Jack, Thomas; Ruepp, Marc-David; Mühlemann, Oliver; Thompson, Andrew James; Lummis, Sarah C. R.; Lochner, Martin (August 2013). Synthesis and testing of photoaffinity probes for the site-selective chemical modification of the 5-HT3 receptor. CHIMIA, 67(7/8), p. 519. Schweizerische Chemische Gesellschaft

Simonin, Jonathan; Jack, Thomas; Ruepp, Marc-David; Hothersall, Daniel; Connolly, Christopher; Chicca, Andrea; Gertsch, Jürg; Thompson, Andrew James; Lummis, Sarah C. R.; Lochner, Martin (August 2013). Synthesis of fluorescent probes for the study of the 5-HT3 receptor: applications in imaging and fluorescence polarization. CHIMIA, 67(7/8), p. 524. Schweizerische Chemische Gesellschaft

Hemmings, Jennifer Luise; Ladds, Graham; Knight, Anthony; Frenguelli, Bruno G.; Lochner, Martin (August 2013). Synthesis of novel fluorescent agonists, with selectivity for the A1 adenosine receptor. CHIMIA, 67(7/8), p. 532. Schweizerische Chemische Gesellschaft

Singhanat, Suradech; Ruepp, Marc-David; Jack, Thomas; Rougier, Jean-Sébastien; Abriel, Hugues; Mühlemann, Oliver; Lochner, Martin (August 2013). Towards the site-specific modification of the hERG K+ channel. CHIMIA, 67(7/8), p. 532. Schweizerische Chemische Gesellschaft

Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Singhanat, Suradech; Hemmings, Jennifer Luise; Leuenberger, Michele; Ruepp, Marc-David; Thompson, Andrew James (9 June 2013). Synthesis of Molecular Tools for the Cellular Study of Ion Channels and Receptors (Unpublished). In: Gordon Research Conference Bioorganic Chemistry. Andover, NH, USA. 09.-14.06.2013.

Hofer, Alexandre; Kovacs, Gergely; Zappatini, Anna; Leuenberger, Michele; Hediger, Matthias A.; Lochner, Martin (2013). Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Bioorganic & medicinal chemistry, 21(11), pp. 3202-3213. Elsevier 10.1016/j.bmc.2013.03.037

Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Singhanat, Suradech; Hemmings, Jennifer Luise; Leuenberger, Michele; Thompson, Andrew James; Ruepp, Marc-David (26 April 2013). Chemical Tools for the Study and Modification of Ion Channels and Receptors (Unpublished). In: BioChemLig Meeting. Bern. 26.04.2013.

Kanai, Yoshikatsu; Clemençon, Benjamin; Simonin, Alexandre; Leuenberger, Michele; Lochner, Martin; Weisstanner, Martin; Hediger, Matthias A. (2013). The SLC1 high-affinity glutamate and neutral amino acid transporter family. Molecular aspects of medicine, 34(2-3), pp. 108-120. Elsevier 10.1016/j.mam.2013.01.001

2012

Simonin, Jonathan; Vernekar, Sanjeev Kumar V.; Thompson, Andrew J.; Hothersall, J.Daniel; Connolly, Christopher N.; Lummis, Sarah C.R.; Lochner, Martin (2012). High-affinity fluorescent ligands for the 5-HT3 receptor. Bioorganic and medicinal chemistry letters, 22(2), pp. 1151-1155. New York, N.Y.: Pergamon 10.1016/j.bmcl.2011.11.097

Hemmings, Jennifer L.; Frenguelli, Bruno G.; Lochner, Martin (2012). Synthesis of novel fluorescent agonists, with selectivity for the A1 adenosine receptor. In: CUSO summer school "Chemical Biology" book of abstracts.

Jack, Thomas; Lochner, Martin (2012). Synthesis and testing of photoaffinity probes for the site-selective chemical modifications of the 5-HT3 receptor. In: CUSO summer school "Chemical Biology" book of abstracts.

Simonin, Jonathan; Chicca, Andrea; Gertsch, Jürg; Lochner, Martin (2012). High affinity fluorescent probes to study the 5-HT3 receptor: applications in imaging and flow cytometry. In: CUSO summer school "Chemical Biology" book of abstracts.

Singhanat, Suradech; Rougier, Jean-Sébastien; Abriel, Hugues; Lochner, Martin (2012). Towards the site-specific modification of the hERG channel. In: CUSO summer school "Chemical Biology" book of abstracts.

Simonin, Jonathan; Chicca, Andrea; Gertsch, Jürg; Lochner, Martin (2012). High affinity fluorescent probes to study the 5-HT3 receptor: applications in imaging and flow cytometry. CHIMIA, 66(7/8), p. 558. Bern: Schweizerische Chemische Gesellschaft

Jack, Thomas; Lochner, Martin (2012). Synthesis and testing of photoaffinity probes for the site-selective chemical modifications of the 5-HT3 receptor. CHIMIA, 66(7/8), p. 558. Bern: Schweizerische Chemische Gesellschaft

Hemmings, Jennifer L.; Frenguelli, Bruno G.; Lochner, Martin (2012). Synthesis of novel fluorescent agonists, with selectivity for the A1 adenosine receptor. CHIMIA, 66(7-8), p. 314. Bern: Schweizerische Chemische Gesellschaft

Hofer, Alexandre; Leuenberger, Michele; Kovacs, Gergely; Hediger, Matthias A.; Lochner, Martin (2012). Synthesis of 2-APB analogues as inhibitors of TRPV6-mediated Calcium transport. CHIMIA, 66(7-8), p. 558. Bern: Schweizerische Chemische Gesellschaft

Singhanat, Suradech; Rougier, Jean-Sébastien; Abriel, Hugues; Lochner, Martin (2012). Towards the site-specific modification of the hERG channel. CHIMIA, 66(7/8), p. 559. Bern: Schweizerische Chemische Gesellschaft

Lochner, Martin (2012). Synthese von molekularen Werkzeugen zur Untersuchung von Ionenkanälen. In: Memorialsymposium zum Gedenken an Prof. M. Hesse, Universität Zürich.

Hemmings, Jennifer L.; Frenguelli, Bruno G.; Lochner, Martin (2012). Synthesis of novel fluorescent agonists, with selectivity for the A1 adenosine receptor. In: Challenges in Organic Chemistry and Chemical Biology (ISACS7), Edinburgh, book of abstracts.

Lochner, Martin (2012). Tailor-made tools (feature); Micro machines. International Innovation, pp. 43-45.

Leuenberger, Michele; Lochner, Martin (2012). Developing chemical tools for the study of transporters. In: Institute of Biochemistry and Molecular Medicine mini-symposium, University of Bern.

Hemmings, Jennifer L.; Frenguelli, Bruno G.; Lochner, Martin (2012). Synthesis of novel fluorescent agonists, with selectivity for the A1 adenosine receptor. In: CUSO subject day "Chemical Biology", University of Basel, book of abstracts.

2011

Lochner, Martin (16 June 2011). Molecular Tools for the Biological Study of Ion Channels (Unpublished). In: Young Faculty Meeting of the Swiss Academy of Sciences (Platform Chemistry). Bern. 16.06.2011.

2010

Quek, Gracia X. J.; Lin, Diana; Halliday, Jill I.; Absalom, Nathan; Ambrus, Joseph I.; Thompson, Andrew J.; Lochner, Martin; Lummis, Sarah C. R.; McLeod, Malcolm D.; Chebib, Mary (2010). Identifying the Binding Site of Novel Methyllycaconitine (MLA) Analogs at alpha 4 beta 2 Nicotinic Acetylcholine Receptors. ACS chemical neuroscience, 1(12), pp. 796-809. Washington, D.C.: American Chemical Society 10.1021/cn100073x

Lochner, Martin; Lummis, Sarah C.R. (2010). Agonists and Antagonists Bind to an A-A Interface in the Heteromeric 5-HT3AB receptor. Biophysical journal, 98(8), pp. 1494-1502. Bethesda, Md.: Biophysical Society 10.1016/j.bpj.2009.12.4313

Vernekar, Sanjeev Kumar V.; Hallaq, Hasan Y.; Clarkson, Guy; Thompson, Andrew J.; Silvestri, Linda; Lummis, Sarah C. R.; Lochner, Martin (2010). Toward Biophysical Probes for the Serotonin 5-HT3 Receptor: Structure–Activity Relationship Study of Granisetron Derivatives. Journal of medicinal chemistry, 53(5), pp. 2324-2328. Easton, Pa.: American Chemical Society 10.1021/jm901827x

Lochner, Martin (2010). Expanding the Small Molecular Toolbox to Study Big Biomolecular Machines. CHIMIA, 64(4), pp. 241-246. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2010.241

2009

Lochner, Martin; Hallaq, Hasan Y.; Menary, Jennifer; Stephenson, James D.; Vernekar, Sanjeev K.; Thompson, Andrew J.; Lummis, Sarah C. R. (5 June 2009). Synthetic Neuroscience - Towards the Chemical Modification of a Ligand-gated Ion Channel Receptor (Unpublished). In: RSC/BPS conference 'Ion Channels as Therapeutic Targets'. Horsham, UK. 05.-06.02.2009.

2008

Lochner, Martin (23 September 2008). Synthetic Neuroscience -Towards the Chemical Modification of a Ligand-gated Ion Channel Receptor (Unpublished). In: RSC Bio-Organic Group Forum (BOG-F1). Leicester, UK. 23.09.2008.

Thompson, Andrew James; Lochner, Martin; Lummis, S.C.R. (2008). Loop B Is a Major Structural Component of the 5-HT3 Receptor. Biophysical journal, 95(12), pp. 5728-5736. Biophysical Society 10.1529/biophysj.108.135624

2007

Lochner, Martin (28 September 2007). Towards the chemical modification of the serotonin 5-HT3 receptor (Unpublished). In: Gregynog Synthesis Workshop. Gregynog, Wales, UK. 28.-30.09.2007.

Thompson, Andrew James; Lochner, Martin; Lummis, S. C. R. (2007). The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT 3 receptors. British journal of pharmacology, 151(5), pp. 666-677. Wiley-Blackwell 10.1038/sj.bjp.0707238

2005

Lochner, Martin (6 July 2005). Structural and Functional Study of the Serotonin 5-HT3A/B Receptor Binding Site (Unpublished). In: British Pharmacology Society Summer Meeting. Cambridge, UK. 06.-08.07.2005.

Lochner, Martin (1 June 2005). Models for Ligand-gated Ion Channels - Structural and Functional Study of the Serotonin 5-HT3A/B Receptor Binding Site (Unpublished). In: Young Chemists Workshop/CERC3 meeting 'Biophysical Chemistry Meets Molecular Medicine'. Sesimbra, Portugal. 01.-04.06.2005.

Lochner, Martin; Atkinson, Stephen J.; Di Francesco, Maria Emilia; Kühn, Toralf; Lorenz, Katrin; Paterson, Ian (2005). Studies towards the total synthesis of peloruside A. In: 229th ACS Spring National Meeting, Abstracts of Papers of the American Chemical Society. San Diego, Californien. 13.03.-17.03.2005.

2004

Lochner, Martin (7 October 2004). Studies Towards the Total Synthesis of (+)-Peloruside A (Unpublished). In: Fall Meeting of the Swiss Chemical Society. Zürich. 07.10.2004.

Lochner, Martin (13 September 2004). Studies Towards the Total Synthesis of (+)-Peloruside A (Unpublished). In: Young Scientists Conference on Bioorganic Chemistry. Hamburg, Germany. 13.-15.09.2004.

Lochner, Martin; Atkinson, Stephen J.; Di Francesco, Emilia M.; Kühn, Toralf; Paterson, Ian (17 April 2004). Studies Towards the Total Synthesis of (+)-Peloruside A (Unpublished). In: 39. EUCHEM Bürgenstock Conference on Stereochemistry. Bürgenstock, Switzerland. 17.-23.04.2004.

Lochner, Martin (2004). The 39th EUCHEM Bürgenstock Conference on Stereochemistry (conference report). CHIMIA, 58, pp. 414-421. Bern: Schweizerische Chemische Gesellschaft

2003

Lochner, Martin; Mu, Linjing; Woggon, Wolf-D. (2003). Remote Effects Modulating the Spin Equilibrium of the Resting State of Cytochrome P450cam –An Investigation Using Active Site Analogues. Advanced synthesis & catalysis, 345(6-7), pp. 743-765. Wiley-VCH 10.1002/adsc.200303011

Lochner, Martin; Meuwly, Markus; Woggon, Wolf-D. (2003). The origin of the low-spin character of the resting state of cytochrome P450cam investigated by means of active site analogues. Chemical communications, 2003(12), pp. 1330-1332. Royal Society of Chemistry 10.1039/b302274a

2002

Lochner, Martin (17 October 2002). A Crown-Capped Iron Porphyrin Mimicking the Resting State of Cytochrome P450cam (Unpublished). In: Fall Meeting of the Swiss Chemical Society. Basel, Switzerland. 17.10.2002.

Lochner, Martin; Woggon, Wolf-D. (25 September 2002). A Crown-Capped Iron Porphyrin Mimicking the Resting State of Cytochrome P450cam (Unpublished). In: 22. Regiosymposium of Organic and Bioorganic Chemistry. Falkau-Feldberg, Germany. 25.-27.09.2002.

2001

Lochner, Martin (12 October 2001). A Novel Iron Porphyrin Mimicking the Resting State of Cytochrome P450cam (Unpublished). In: Fall Meeting of the Swiss Chemical Society. Zürich, Switzerland. 12.10.2001.

Lochner, Martin; Mu, Linjing; Müller, Michael; Woggon, Wolf-D. (8 March 2001). Synthesis of an Active Site Analogue of the Resting State of Cytochrome P450cam (Unpublished). In: 4th Lausanne Conference on Bioorganic Chemistry. Lausanne, Switzerland. 08.-09.03.2001.

Robillard, Marc S.; Jansen, Bart A. J.; Lochner, Martin; Geneste, Hervé; Li, Yi; Brouwer, Jaap; Hesse, Manfred; Reedijk, Jan (2001). Mononuclear Tetraamineplatinum(II) Complexes: Synthesis, Anticancer Activity, DNA Binding, and Cellular Uptake. Helvetica chimica acta, 84(10), pp. 3023-3030. Verlag Helvetica Chimica Acta 10.1002/1522-2675(20011017)84:10<3023::AID-HLCA3023>3.0.CO;2-Z

Liao, Ying; Popaj, Kasim; Lochner, Martin; Geneste, Herve; Budriesi, Roberta; Chiarini, Alberto; Melchiorre, Carlo; Hesse, Manfred (2001). Analogues of polyamine alkaloids and their synthetic advantages. Il Farmaco, 56(1-2), pp. 127-131. Elsevier 10.1016/S0014-827X(01)01021-7

1998

Lochner, Martin; Geneste, Hervé; Hesse, Manfred (1998). Allgemeiner Zugang zu Polyaminen mit Ethan-1,2-diamin-Einheiten: Synthese von nicht natürlich vorkommenden homologen und isomerenN1,4-Di(4-cumaroyl)sperminen. Helvetica chimica acta, 81(12), pp. 2270-2281. Verlag Helvetica Chimica Acta 10.1002/(SICI)1522-2675(19981216)81:12<2270::AID-HLCA2270>3.0.CO;2-#

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