Gender-related differences in aneurysmal subarachnoid hemorrhage: A hospital based study.

De Marchis, Gian Marco; Schaad, Chris; Fung, Christian; Beck, Jürgen; Gralla, Jan; Takala, Jukka; Jakob, Stephan (2017). Gender-related differences in aneurysmal subarachnoid hemorrhage: A hospital based study. Clinical neurology and neurosurgery, 157, pp. 82-87. Elsevier 10.1016/j.clineuro.2017.04.009

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OBJECTIVES Aneurysmal subarachnoid hemorrhage (aSAH) is more common in women than in men. Despite its clinical relevance, knowledge about the potential gender differences in the clinical course and outcome of aSAH is sparse - we aimed at elucidating such differences. PATIENTS AND METHODS Retrospective cohort study including patients ≥18years of age with aSAH admitted to an interdisciplinary intensive-care center at the University Hospital of Bern (Switzerland). RESULTS The study included 120 patients with aSAH. Sixty-nine percent of the enrolled patients were women. The women were older than men (mean [standard deviation] age 58±13years vs. 51±12years, P=0.006), and were increasingly overrepresented across increasing age-strata. Global disease severity at admission, measured by the APACHE II score, was higher in women than in men (median score 18 points [IQR 12-26] vs. 14 points [IQR 10-19], P=0.006). Men and women had similar medical histories and severity of aSAH. We found no evidence for major differences in the adopted aneurysm-securing strategy and intensive care interventions. At 6 months from aSAH, mortality was higher in women than men (28% vs. 16%), but this did not reach statistical significance (P=0.25). APACHE II, but not gender, was associated with unfavorable outcome at 6 months. CONCLUSION Women outnumbered men among aSAH patients, especially along increasing age strata, and had increased global disease severity on admission. No other significant differences between genders were found.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

De Marchis, Gian Marco; Schaad, Chris; Fung, Christian; Beck, Jürgen; Gralla, Jan; Takala, Jukka and Jakob, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0303-8467

Publisher:

Elsevier

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

08 Aug 2017 08:42

Last Modified:

08 Aug 2017 08:42

Publisher DOI:

10.1016/j.clineuro.2017.04.009

PubMed ID:

28456071

Uncontrolled Keywords:

Gender differences; Outcome; Subarachnoid hemorrhage

BORIS DOI:

10.7892/boris.100089

URI:

https://boris.unibe.ch/id/eprint/100089

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