Improved detection of alcohol consumption using the novel marker phosphatidylethanol in the transplant setting: results of a prospective study.

Andresen-Streichert, Hilke; Beres, Yannick; Weinmann, Wolfgang; Schröck, Alexandra; Müller, Alexander; Skopp, Gisela; Pischke, Sven; Vettorazzi, Eik; Lohse, Ansgar; Nashan, Björn; Sterneck, Martina (2017). Improved detection of alcohol consumption using the novel marker phosphatidylethanol in the transplant setting: results of a prospective study. Transplant international, 30(6), pp. 611-620. Wiley-Blackwell 10.1111/tri.12949

[img] Text
Andresen-Streichert_et_al-2017-Transplant_International.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (373kB) | Request a copy

Phosphatidylethanol (PEth) is a new, highly specific alcohol marker. The aim of this study was to assess its diagnostic value in the liver transplant setting. In 51 pre- and 61 post-transplant patients with underlying alcoholic liver disease PEth, ethanol, methanol, carbohydrate-deficient transferrin (CDT), and ethyl glucuronide in urine (uEtG) and hair (hEtG) were tested and compared with patients' questionnaire reports. Twenty-eight (25%) patients tested positive for at least one alcohol marker. PEth alone revealed alcohol consumption in 18% of patients. With respect to detection of alcohol intake in the preceding week, PEth showed a 100% sensitivity. PEth testing was more sensitive than the determination of ethanol, methanol, CDT or uEtG alone [sensitivity 25% (confidence interval (CI) 95%, 7-52%), 25% (7-52%), 21% (6-45%) and 71% (41-91%), respectively], or ethanol, methanol and uEtG taken in combination with 73% (45-92%). Specificity of all markers was 92% or higher. Additional testing of hEtG revealed alcohol consumption in seven patients, not being positive for any other marker. Phosphatidylethanol was a highly specific and sensitive marker for detection of recent alcohol consumption in pre- and post-transplant patients. The additional determination of hEtG was useful in disclosing alcohol consumption 3-6 months retrospectively.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Chemistry and Toxicology

UniBE Contributor:

Weinmann, Wolfgang

ISSN:

0934-0874

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Antoinette Angehrn

Date Deposited:

07 Aug 2017 13:05

Last Modified:

07 Aug 2017 13:05

Publisher DOI:

10.1111/tri.12949

PubMed ID:

28295675

Uncontrolled Keywords:

alcoholic liver disease; carbohydrate-deficient transferrin; cirrhosis; ethyl glucuronide; methanol; phosphatidylethanol

BORIS DOI:

10.7892/boris.100161

URI:

https://boris.unibe.ch/id/eprint/100161

Actions (login required)

Edit item Edit item
Provide Feedback