Ranid Herpesvirus 3 and Proliferative Dermatitis in Free-Ranging Wild Common Frogs (Rana Temporaria)

Origgi, Francesco; Schmidt, B. R.; Lohmann, P.; Otten, P.; Akdesir, Ezgi; Gaschen, Véronique; Aguilar Bultet, Lisandra; Wahli, Thomas; Sattler, Ursula; Stoffel, Michael Hubert (2017). Ranid Herpesvirus 3 and Proliferative Dermatitis in Free-Ranging Wild Common Frogs (Rana Temporaria). Veterinary pathology, 54(4), pp. 686-694. American College of Veterinary Pathologists 10.1177/0300985817705176

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Amphibian pathogens are of current interest as contributors to the global decline of amphibians. However, compared with chytrid fungi and ranaviruses, herpesviruses have received relatively little attention. Two ranid herpesviruses have been described: namely, Ranid herpesvirus 1 (RHV1) and Ranid Herpesvirus 2 (RHV2). This article describes the discovery and partial characterization of a novel virus tentatively named Ranid herpesvirus 3 (RHV3), a candidate member of the genus Batrachovirus in the Family Alloherpesviridae. RHV3 infection in wild common frogs (Rana temporaria) was associated with severe multifocal epidermal hyperplasia, dermal edema, a minor inflammatory response, and variable mucous gland degeneration. Intranuclear inclusions were numerous in the affected epidermis together with unique extracellular aggregates of herpesvirus-like particles. The RHV3-associated skin disease has features similar to those of a condition recognized in European frogs for the last 20 years and whose cause has remained elusive. The genome of RHV3 shares most of the features of the Alloherpesviruses. The characterization of this presumptive pathogen may be of value for amphibian conservation and for a better understanding of the biology of Alloherpesviruses.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Anatomy
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Microscopy Imaging Center MIC
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)

UniBE Contributor:

Origgi, Francesco; Akdesir, Ezgi; Gaschen, Véronique; Aguilar Bultet, Lisandra; Wahli, Thomas; Sattler, Ursula and Stoffel, Michael Hubert

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0300-9858

Publisher:

American College of Veterinary Pathologists

Language:

English

Submitter:

Miriam Francine Heinzelmann

Date Deposited:

13 Sep 2017 10:51

Last Modified:

11 Jan 2019 13:39

Publisher DOI:

10.1177/0300985817705176

PubMed ID:

28494706

BORIS DOI:

10.7892/boris.100877

URI:

https://boris.unibe.ch/id/eprint/100877

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