A research agenda for malaria eradication: basic science and enabling technologies

Amino, R.; Bassat, Q.; Baum, J.; Billker, O.; Bogyo, M.; Bousema, T.; Christophides, G.; Deitsch, K.; Dinglasan, R.; Djimde, A.; Duraisingh, M.; Dzinjalamala, F.; Happi, C.; Heussler, Volker; Kramarik, J.; de Koning-Ward, T.; Lacerda, M.; Laufer, M.; Lim, P.; Llinas, M.; ... (2011). A research agenda for malaria eradication: basic science and enabling technologies. PLoS medicine, 8(1), e1000399. San Francisco, Calif.: Public Library of Science 10.1371/journal.pmed.1000399

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Today's malaria control efforts are limited by our incomplete understanding of the biology of Plasmodium and of the complex relationships between human populations and the multiple species of mosquito and parasite. Research priorities include the development of in vitro culture systems for the complete life cycle of P. falciparum and P. vivax and the development of an appropriate liver culture system to study hepatic stages. In addition, genetic technologies for the manipulation of Plasmodium need to be improved, the entire parasite metabolome needs to be characterized to identify new druggable targets, and improved information systems for monitoring the changes in epidemiology, pathology, and host-parasite-vector interactions as a result of intensified control need to be established to bridge the gap between bench, preclinical, clinical, and population-based sciences.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology
08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria

UniBE Contributor:

Heussler, Volker

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1549-1277

Publisher:

Public Library of Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:27

Last Modified:

11 May 2016 09:57

Publisher DOI:

10.1371/journal.pmed.1000399

Web of Science ID:

000286594200014

BORIS DOI:

10.7892/boris.10096

URI:

https://boris.unibe.ch/id/eprint/10096 (FactScience: 215935)

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