Chronicle of a death foretold: Plasmodium liver stage parasites decide on the fate of the host cell

Graewe, S.; Stanway, R. R.; Rennenberg, A.; Heussler, Volker (2012). Chronicle of a death foretold: Plasmodium liver stage parasites decide on the fate of the host cell. FEMS microbiology reviews, 36(1), pp. 111-130. Malden, Mass.: Blackwell Publishing Ltd 10.1111/j.1574-6976.2011.00297.x

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Protozoan parasites of the genus Plasmodium are the causative agents of malaria. Despite more than 100 years of research, the complex life cycle of the parasite still bears many surprises and it is safe to say that understanding the biology of the pathogen will keep scientists busy for many years to come. Malaria research has mainly concentrated on the pathological blood stage of Plasmodium parasites, leaving us with many questions concerning parasite development within the mosquito and during the exo-erythrocytic stage in the vertebrate host. After the discovery of the Plasmodium liver stage in the middle of the last century, it remained understudied for many years but the realization that it represents a promising target for vaccination approaches has brought it back into focus. The last decade saw many new and exciting discoveries concerning the exo-erythrocytic stage and in this review we will discuss the highlights of the latest developments in the field.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology
08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria

UniBE Contributor:

Limenitakis, Rebecca and Heussler, Volker

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0168-6445

Publisher:

Blackwell Publishing Ltd

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:27

Last Modified:

24 Oct 2019 01:05

Publisher DOI:

10.1111/j.1574-6976.2011.00297.x

Web of Science ID:

000298061900006

BORIS DOI:

10.7892/boris.10098

URI:

https://boris.unibe.ch/id/eprint/10098 (FactScience: 215937)

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