Waist circumference is associated with liver fat in black and white adolescents.

Lee, SoJung; Kuk, Jennifer L; Boesch, Christoph Hans; Arslanian, Silva (2017). Waist circumference is associated with liver fat in black and white adolescents. Applied physiology, nutrition, and metabolism, 42(8), pp. 829-833. NRC Research Press 10.1139/apnm-2016-0410

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We examined whether waist circumference (WC) is associated with liver fat in black and white adolescents. Liver fat was measured using a 3T proton magnetic resonance spectroscopy (1H-MRS) in 152 overweight/obese adolescents (94 black and 58 white, BMI >85th percentile, 12-18 yrs) without liver diseases or diabetes. WC was measured at the last rib. Total and visceral adipose tissue (VAT) were measured by DXA and MRI, respectively. The proportion of fatty liver (defined as liver fat >5.0% by 1H-MRS) was lower (P<0.01) in black adolescents (5.3%) compared with their white peers (24.1%). Despite similar age, BMI, WC and total adiposity (%), blacks had lower (P<0.01) VAT (59.0 versus 81.3 cm2), liver fat (1.6 versus 3.5 %) and ALT (17.2 versus 22.0 IU/L) compared with their white peers. Independent of race, WC was associated with liver fat (black r=0.43, white r=0.64) in a similar magnitude to the association between VAT and liver fat (black r=0.44, white r=0.51) and these findings remained significant after controlling for age, gender, Tanner stage and total adiposity. In blacks, WC and gender (male) were independent (P<0.01) predictors of liver fat, explaining 17.1% and 5.6% of the variance, respectively, while in whites WC was the single best predictor, explaining 40.8% of the variance in liver fat. These findings suggest that enlarged WC is a marker of increased liver fat in overweight/obese white and black adolescents.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Boesch, Christoph Hans

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1715-5320

Publisher:

NRC Research Press

Language:

English

Submitter:

Christoph Hans Boesch

Date Deposited:

08 Jun 2017 16:05

Last Modified:

26 Jul 2017 01:31

Publisher DOI:

10.1139/apnm-2016-0410

PubMed ID:

28334548

URI:

https://boris.unibe.ch/id/eprint/101048

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