Hepatitis B treatment eligibility in West Africa: uncertainties and need for prospective cohort studies.

Jaquet, Antoine; Nouaman, Marcellin; Tine, Judicaël; Tanon, Aristophane; Anoma, Camille; Inwoley, André; Attia, Alain; Ekouevi, Didier K; Seydi, Moussa; Dabis, François; Wandeler, Gilles (2017). Hepatitis B treatment eligibility in West Africa: uncertainties and need for prospective cohort studies. Liver international, 37(8), pp. 1116-1121. Blackwell Munksgaard 10.1111/liv.13484

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BACKGROUND & AIMS While universal screening of hepatitis B virus (HBV) is recommended in high burden countries, little is known about the proportion of HBV-infected persons in need of antiviral therapy in these settings. METHODS Prisoners in Senegal and Togo, as well as female sex workers and men who have sex with men in Cote d'Ivoire were screened for HBV infection. All HBsAg-positive participants underwent transient elastography, alanine aminotransferase (ALT) and HBV viral load quantification. Individuals with liver cirrhosis or those aged>30 years with an HBV replication ≥20 000 IU/ml and elevated ALT were considered eligible for antiviral therapy. RESULTS Of 1 256 participants, 110 (8.8%) were HBsAg-positive; their median age was 30 years [interquartile range: 25-33] and 96 (86.5%) were men. Three individuals (2.7%) had liver cirrhosis while 28 (29.5%) of 94 participants with available measurements had an HBV viral load ≥20 000 IU/ml. Overall, 11 (10.0%) subjects were considered eligible for immediate antiviral treatment; 2.1% of participants in Dakar, 7.7% in Abidjan and 21.6% in Lome (p=0.001) and 59 (53.4%) for close monitoring due to the presence of significant liver fibrosis, elevated ALT or significant HBV replication. CONCLUSIONS Among vulnerable populations in West Africa, a minority of HBV-infected individuals were eligible for immediate antiviral therapy. Prospective cohort studies are necessary to evaluate anti-HBV treatment eligibility facing the significant proportion of individuals with active chronic HBV infection. This article is protected by copyright. All rights reserved.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Wandeler, Gilles

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1478-3223

Publisher:

Blackwell Munksgaard

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

04 Jul 2017 11:43

Last Modified:

01 Sep 2018 02:30

Publisher DOI:

10.1111/liv.13484

PubMed ID:

28561454

Uncontrolled Keywords:

Africa Antiviral treatment Hepatitis B virus

BORIS DOI:

10.7892/boris.101234

URI:

https://boris.unibe.ch/id/eprint/101234

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