Novel Magnetic Resonance Imaging for Assessment of Bronchial Stenosis in Lung Transplant Recipients.

Mahmood, K; Ebner, Lukas; He, M; Robertson, S H; Wang, Z; McAdams, H P; Wahidi, M M; Shofer, S L; Huang, Y T; Driehuys, B (2017). Novel Magnetic Resonance Imaging for Assessment of Bronchial Stenosis in Lung Transplant Recipients. American journal of transplantation, 17(7), pp. 1895-1904. Wiley-Blackwell 10.1111/ajt.14287

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Bronchial stenosis in lung transplant recipients is a common disorder that adversely affects clinical outcomes. It is evaluated by spirometry, CT scanning, and bronchoscopy with significant limitations. We hypothesize that MRI using both ultrashort echo time (UTE) scans and hyperpolarized (HP) (129) Xe gas can offer structural and functional assessment of bronchial stenosis seen after lung transplantation. Six patients with lung transplantation-related bronchial stenosis underwent HP (129) Xe MRI and UTE MRI in the same session. Three patients subsequently underwent airway stent placement and had repeated MRI at 4-week follow-up. HP (129) Xe MRI depicted decreased ventilation distal to the stenotic airway. After airway stent placement, MRI showed that low-ventilation regions had decreased (35% vs. 27.6%, p = 0.006) and normal-ventilation regions had increased (17.9% vs. 27.6%, p = 0.04) in the stented lung. Improved gas transfer was also seen on (129) Xe MRI. There was a good correlation between UTE MRI and independent bronchoscopic airway diameter assessment (Pearson correlation coefficient = 0.92). This pilot study shows that UTE and HP (129) Xe MRI are feasible in patients with bronchial stenosis related to lung transplantation and may provide structural and functional airway assessment to guide treatment. These conclusions need to be confirmed with larger studies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Ebner, Lukas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1600-6135

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Santa Bertina Schiaroli

Date Deposited:

12 Jul 2018 12:04

Last Modified:

12 Jul 2018 12:04

Publisher DOI:

10.1111/ajt.14287

PubMed ID:

28371091

Uncontrolled Keywords:

clinical research/practice lung (allograft) function/dysfunction lung transplantation/pulmonology surgical technique

BORIS DOI:

10.7892/boris.101299

URI:

https://boris.unibe.ch/id/eprint/101299

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