Functional MRI for the prediction of treatment response in head and neck squamous cell carcinoma: potential and limitations.

King, Ann D; Thöny, Harriet C. (2016). Functional MRI for the prediction of treatment response in head and neck squamous cell carcinoma: potential and limitations. Cancer imaging : the official publication of the International Cancer Imaging Society, 16(1), p. 23. BioMed Central 10.1186/s40644-016-0080-6

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Pre-treatment or early intra-treatment prediction of patients with head and neck squamous cell carcinomas (HNSCC) who are likely to have tumours that are resistant to chemoradiotherapy (CRT) would enable treatment regimens to be changed at an early time point, or allow patients at risk of residual disease to be targeted for more intensive post-treatment investigation. Research into the potential advantages of using functional-based magnetic resonance imaging (MRI) sequences before or during cancer treatments to predict treatment response has been ongoing for several years. In regard to HNSCC, the reported results from functional MRI research are promising but they have yet to be transferred to the clinical domain. This article will review the functional MRI literature in HNSCC to determine the current status of the research and try to identify areas that are close to application in clinical practice. This review will focus on diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) and briefly include proton magnetic resonance spectroscopy ((1)H-MRS)and blood oxygen level dependent (BOLD) MRI.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Thöny, Harriet C.

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1470-7330

Publisher:

BioMed Central

Language:

English

Submitter:

Nicole Rösch

Date Deposited:

04 Jun 2018 09:41

Last Modified:

17 Jun 2018 02:16

Publisher DOI:

10.1186/s40644-016-0080-6

PubMed ID:

27542718

Uncontrolled Keywords:

Cancer Chemotherapy DCE DWI Head and neck MRI MRS Radiotherapy Response Squamous cell carcinoma

BORIS DOI:

10.7892/boris.101438

URI:

https://boris.unibe.ch/id/eprint/101438

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