High resolution CBV assessment with PEAK-EPI: k-t-undersampling and reconstruction in echo planar imaging.

Ramb, Rebecca; Mader, Irina; Jung, Bernd; Hennig, Jürgen; Zaitsev, Maxim (2017). High resolution CBV assessment with PEAK-EPI: k-t-undersampling and reconstruction in echo planar imaging. Magnetic resonance in medicine, 77(6), pp. 2153-2166. Wiley-Liss 10.1002/mrm.26298

[img] Text
Ramb_et_al-2017-Magnetic_Resonance_in_Medicine.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (5MB) | Request a copy

PURPOSE Achieving higher spatial resolution and improved brain coverage while mitigating in-plane susceptibility artifacts in the assessment of perfusion parameters, such as cerebral blood volume, in echo planar imaging (EPI)-based dynamic susceptibility contrast weighted cerebral perfusion measurements. METHODS PEAK-EPI, an EPI sequence with interleaved readout trajectories and three different strategies for autocalibration-signal acquisition (inplace, dynamic extra and extra) is presented. Performance of each approach is analyzed in vivo based on flip angle variation induced dynamics, assessing temporal fidelity, temporal SNR and g-factors. All approaches are compared with conventional GRAPPA reconstructions. PEAK-EPI with inplace autocalibration-signal at R = 5 is then compared with the standard clinical EPI protocol in six patients, using two half-dose dynamic susceptibility contrast weighted cerebral perfusion measurements per subject. RESULTS PEAK-EPI acquisition facilitates a substantial increase of spatial resolution at a higher number of slices per TR and provides improved SNR compared to conventional GRAPPA. High dependency of the resulting reconstruction quality on the type of autocalibration-signal acquisition is observed. PEAK-EPI with inplace autocalibration-signal achieves high temporal fidelity and initial feasibility is shown. CONCLUSION The obtained high resolution cerebral blood volume maps reveal more detailed information than in corresponding standard EPI measurements and facilitate detailed delineation of tumorous tissue. Magn Reson Med 77:2153-2166, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Jung, Bernd

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0740-3194

Publisher:

Wiley-Liss

Language:

English

Submitter:

Nicole Rösch

Date Deposited:

13 Sep 2017 13:01

Last Modified:

13 Sep 2017 13:01

Publisher DOI:

10.1002/mrm.26298

PubMed ID:

27343201

Uncontrolled Keywords:

DSC-MRI EPI GRAPPA PEAK-GRAPPA cerebral perfusion

BORIS DOI:

10.7892/boris.101441

URI:

https://boris.unibe.ch/id/eprint/101441

Actions (login required)

Edit item Edit item
Provide Feedback