Impact of the calculation algorithm on biexponential fitting of diffusion-weighted MRI in upper abdominal organs.

Barbieri, Sebastiano; Donati, Olivio F; Froehlich, Johannes M; Thöny, Harriet C. (2016). Impact of the calculation algorithm on biexponential fitting of diffusion-weighted MRI in upper abdominal organs. Magnetic resonance in medicine, 75(5), pp. 2175-2184. Wiley-Liss 10.1002/mrm.25765

Text Barbieri_et_al-2016-Magnetic_Resonance_in_Medicine.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (6MB) | Request a copy

PURPOSE

To compare the variability, precision, and accuracy of six different algorithms (Levenberg-Marquardt, Trust-Region, Fixed-Dp , Segmented-Unconstrained, Segmented-Constrained, and Bayesian-Probability) for computing intravoxel-incoherent-motion-related parameters in upper abdominal organs.

METHODS

Following the acquisition of abdominal diffusion-weighted magnetic resonance images of 10 healthy men, six distinct algorithms were employed to compute intravoxel-incoherent-motion-related parameters in the left and right liver lobe, pancreas, spleen, renal cortex, and renal medulla. Algorithms were evaluated regarding inter-reader and intersubject variability. Comparability of results was assessed by analyses of variance. The algorithms' precision and accuracy were investigated on simulated data.

RESULTS

A Bayesian-Probability based approach was associated with very low inter-reader variability (average Intraclass Correlation Coefficients: 96.5-99.6%), the lowest inter-subject variability (Coefficients of Variation [CV] for the pure diffusion coefficient Dt : 3.8% in the renal medulla, 6.6% in the renal cortex, 10.4-12.1% in the left and right liver lobe, 15.3% in the spleen, 15.8% in the pancreas; for the perfusion fraction Fp : 15.5% on average; for the pseudodiffusion coefficient Dp : 25.8% on average), and the highest precision and accuracy. Results differed significantly (P < 0.05) across algorithms in all anatomical regions.

CONCLUSION

The Bayesian-Probability algorithm should be preferred when computing intravoxel-incoherent-motion-related parameters in upper abdominal organs.

Interest & Impact

Downloads

2 since deposited on 04 Jun 2018
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item