Impact of the calculation algorithm on biexponential fitting of diffusion-weighted MRI in upper abdominal organs.

Barbieri, Sebastiano; Donati, Olivio F; Froehlich, Johannes M; Thöny, Harriet C. (2016). Impact of the calculation algorithm on biexponential fitting of diffusion-weighted MRI in upper abdominal organs. Magnetic resonance in medicine, 75(5), pp. 2175-2184. Wiley-Liss 10.1002/mrm.25765

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PURPOSE To compare the variability, precision, and accuracy of six different algorithms (Levenberg-Marquardt, Trust-Region, Fixed-Dp , Segmented-Unconstrained, Segmented-Constrained, and Bayesian-Probability) for computing intravoxel-incoherent-motion-related parameters in upper abdominal organs. METHODS Following the acquisition of abdominal diffusion-weighted magnetic resonance images of 10 healthy men, six distinct algorithms were employed to compute intravoxel-incoherent-motion-related parameters in the left and right liver lobe, pancreas, spleen, renal cortex, and renal medulla. Algorithms were evaluated regarding inter-reader and intersubject variability. Comparability of results was assessed by analyses of variance. The algorithms' precision and accuracy were investigated on simulated data. RESULTS A Bayesian-Probability based approach was associated with very low inter-reader variability (average Intraclass Correlation Coefficients: 96.5-99.6%), the lowest inter-subject variability (Coefficients of Variation [CV] for the pure diffusion coefficient Dt : 3.8% in the renal medulla, 6.6% in the renal cortex, 10.4-12.1% in the left and right liver lobe, 15.3% in the spleen, 15.8% in the pancreas; for the perfusion fraction Fp : 15.5% on average; for the pseudodiffusion coefficient Dp : 25.8% on average), and the highest precision and accuracy. Results differed significantly (P < 0.05) across algorithms in all anatomical regions. CONCLUSION The Bayesian-Probability algorithm should be preferred when computing intravoxel-incoherent-motion-related parameters in upper abdominal organs.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Barbieri, Sebastiano and Thöny, Harriet C.

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0740-3194

Publisher:

Wiley-Liss

Language:

English

Submitter:

Nicole Rösch

Date Deposited:

04 Jun 2018 10:41

Last Modified:

26 Oct 2019 16:21

Publisher DOI:

10.1002/mrm.25765

PubMed ID:

26059232

Uncontrolled Keywords:

Bayesian abdominal algorithm intravoxel-incoherent-motion least-squares segmented

BORIS DOI:

10.7892/boris.101456

URI:

https://boris.unibe.ch/id/eprint/101456

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