Temperature-corrected post-mortem 1.5 T MRI quantification of non-pathologic upper abdominal organs.

Schwendener, Nicole; Jackowski, Christian; Schuster, Frederick; Persson, Anders; Warntjes, Marcel J; Zech, Wolf-Dieter (2017). Temperature-corrected post-mortem 1.5 T MRI quantification of non-pathologic upper abdominal organs. International journal of legal medicine, 131(5), pp. 1369-1376. Springer 10.1007/s00414-017-1622-6

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OBJECTIVES The present study aimed to evaluate if simultaneous temperature-corrected T1, T2, and proton density (PD) 1.5 T post-mortem MR quantification [quantitative post-mortem magnetic resonance imaging (QPMMRI)] is feasible for characterizing and discerning non-pathologic upper abdominal organs (liver, spleen, pancreas, kidney) with regard to varying body temperatures. METHODS QPMMRI was performed on 80 corpses (25 females, 55 males; mean age 56.2 years, SD 17.2) prior to autopsy. Core body temperature was measured during QPMMRI. Quantitative T1, T2, and PD values were measured in the liver, pancreas, spleen, and left kidney and temperature corrected to 37 °C. Histologic examinations were conducted on each measured organ to determine non-pathologic organs. Quantitative T1, T2, and PD values of non-pathologic organs were ANOVA tested against values of other non-pathologic organ types. RESULTS Based on temperature-corrected quantitative T1, T2, and PD values, ANOVA testing verified significant differences between the non-pathologic liver, spleen, pancreas, and left kidneys. CONCLUSIONS Temperature-corrected 1.5 T QPMMRI based on T1, T2, and PD values may be feasible for characterization and differentiation of the non-pathologic liver, spleen, pancreas, and kidney. The results may provide a base for future specific pathology diagnosis of upper abdominal organs in post-mortem imaging.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Medicine
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Management

UniBE Contributor:

Schwendener, Nicole; Jackowski, Christian; Schuster, Frederick and Zech, Wolf-Dieter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0937-9827

Publisher:

Springer

Language:

English

Submitter:

Antoinette Angehrn

Date Deposited:

07 Aug 2017 12:32

Last Modified:

21 Mar 2018 01:30

Publisher DOI:

10.1007/s00414-017-1622-6

PubMed ID:

28624986

Uncontrolled Keywords:

Abdominal organs; Post-mortem MRI quantification; Post-mortem magnetic resonance imaging; Proton density; Relaxation times

BORIS DOI:

10.7892/boris.101466

URI:

https://boris.unibe.ch/id/eprint/101466

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