Temperature-corrected postmortem 3-T MR quantification of histopathological early acute and chronic myocardial infarction: a feasibility study.

Persson, Anders; Baeckmann, John; Berge, Johan; Jackowski, Christian; Warntjes, Marcel; Zech, Wolf-Dieter (2018). Temperature-corrected postmortem 3-T MR quantification of histopathological early acute and chronic myocardial infarction: a feasibility study. International journal of legal medicine, 132(2), pp. 541-549. Springer 10.1007/s00414-017-1614-6

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The goal of the present study was to evaluate if quantitative postmortem cardiac 3-T magnetic resonance (QPMCMR) T1 and T2 relaxation times and proton density values of histopathological early acute and chronic myocardial infarction differ to the quantitative values of non-pathologic myocardium and other histopathological age stages of myocardial infarction with regard to varying corpse temperatures. In 60 forensic corpses (25 female, 35 male), a cardiac 3-T MR quantification sequence was performed prior to autopsy and cardiac dissection. Core body temperature was assessed during MR examinations. Focal myocardial signal alterations in synthetically generated MR images were measured for their T1, T2, and proton density (PD) values. Locations of signal alteration measurements in PMCMR were targeted at heart dissection, and myocardial tissue specimens were taken for histologic examinations. Quantified signal alterations in QPMCMR were correlated to their according histologic age stage of myocardial infarction, and quantitative values were corrected for a temperature of 37 °C. In QPMCMR, 49 myocardial signal alterations were detected in 43 of 60 investigated hearts. Signal alterations were diagnosed histologically as early acute (n = 16), acute (n = 10), acute with hemorrhagic component (n = 9), subacute (n = 3), and chronic (n = 11) myocardial infarction. Statistical analysis revealed that based on their temperature-corrected quantitative T1, T2, and PD values, a significant difference between early acute, acute, and chronic myocardial infarction can be determined. It can be concluded that quantitative 3-T postmortem cardiac MR based on temperature-corrected T1, T2, and PD values may be feasible for pre-autopsy diagnosis of histopathological early acute, acute, and chronic myocardial infarction, which needs to be confirmed histologically.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Medicine
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine

UniBE Contributor:

Jackowski, Christian and Zech, Wolf-Dieter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0937-9827

Publisher:

Springer

Language:

English

Submitter:

Antoinette Angehrn

Date Deposited:

07 Aug 2017 12:46

Last Modified:

25 Apr 2018 12:46

Publisher DOI:

10.1007/s00414-017-1614-6

PubMed ID:

28612206

Uncontrolled Keywords:

Myocardial infarction; Postmortem MRI; Proton density; Quantitative MRI; Relaxation times

BORIS DOI:

10.7892/boris.101467

URI:

https://boris.unibe.ch/id/eprint/101467

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