A common challenge in older adults: Classification, overlap, and therapy of depression and dementia.

Leyhe, Thomas; Reynolds, Charles F; Melcher, Tobias; Linnemann, Christoph; Klöppel, Stefan; Blennow, Kaj; Zetterberg, Henrik; Dubois, Bruno; Lista, Simone; Hampel, Harald (2017). A common challenge in older adults: Classification, overlap, and therapy of depression and dementia. Alzheimer's & dementia, 13(1), pp. 59-71. Elsevier 10.1016/j.jalz.2016.08.007

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Late-life depression is frequently associated with cognitive impairment. Depressive symptoms are often associated with or even precede a dementia syndrome. Moreover, depressive disorders increase the risk of persistence for mild cognitive impairment and dementia. Here, we present both the current state of evidence and future perspectives regarding the integration and value of clinical assessments, neuropsychological, neurochemical, and neuroimaging biomarkers for the etiological classification of the dementia versus the depression syndrome and for the prognosis of depression relating to dementia risk. Finally, we summarize the existing evidence for both pharmacotherapy and psychotherapy of depression in demented patients. There is an urgent need for large-scale collaborative research to elucidate the role and interplay of clinical and biological features in elderly individuals with depressive disorders who are at elevated risk for developing dementia. To overcome barriers for successful drug development, we propose the introduction of the precision medicine paradigm to this research field.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy

UniBE Contributor:

Klöppel, Stefan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1552-5279

Publisher:

Elsevier

Language:

English

Submitter:

Katharina Klink

Date Deposited:

18 Sep 2017 10:38

Last Modified:

31 Jan 2019 11:05

Publisher DOI:

10.1016/j.jalz.2016.08.007

PubMed ID:

27693188

Uncontrolled Keywords:

Biomarkers Classification Dementia Depression Differential diagnosis Neuroimaging Pharmacotherapy Precision medicine Prognosis Psychological intervention

BORIS DOI:

10.7892/boris.101476

URI:

https://boris.unibe.ch/id/eprint/101476

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