Visual neglect after left-hemispheric lesions: a voxel-based lesion-symptom mapping study in 121 acute stroke patients.

Beume, Lena-Alexandra; Martin, Markus; Kaller, Christoph P; Klöppel, Stefan; Schmidt, Charlotte S M; Urbach, Horst; Egger, Karl; Rijntjes, Michel; Weiller, Cornelius; Umarova, Roza M (2017). Visual neglect after left-hemispheric lesions: a voxel-based lesion-symptom mapping study in 121 acute stroke patients. Experimental brain research, 235(1), pp. 83-95. Springer 10.1007/s00221-016-4771-9

[img] Text
art%3A10.1007%2Fs00221-016-4771-9.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (962kB) | Request a copy

Visual neglect after left-hemispheric lesion is thought to be less frequent, less severe, and shorter lived than visuospatial attention deficits resulting from right-hemispheric lesions. However, reports exist opposing this assumption, and it is unclear how these findings fit into the current theories of visuospatial processing. Furthermore, only little is known about the exact structure-function relationship between visuospatial attention deficits and left-hemispheric stroke. We investigated neglect in 121 patients with acute left-hemispheric ischemic stroke by following clinical development from within the first 24 h of stroke onset until hospital discharge. Visuospatial attention deficits occurred in 17.4 % (n = 21). Voxel-based lesion-symptom mapping associated visual neglect to the right with lesion in the left superior and middle temporal gyrus, temporal pole, frontal operculum, and insula. Neglect severity, captured by the Center of Cancellation Score of the Bells test, was associated with lesion in the left anterior temporal lobe and the left frontal operculum. The left-hemispheric lesion pattern of neglect thus involves areas of the ventral attention system and partly mirrors the critical regions of the right hemisphere known to be associated with neglect. Based on our prospective analysis on a large cohort of patients with left-hemispheric stroke, this study shows that in a remarkable number of patients, the left hemisphere essentially contributes to an intact representation of space and clarifies the impact of the distinct left-hemispheric structures involved in visuospatial processing.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy

UniBE Contributor:

Klöppel, Stefan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0014-4819

Publisher:

Springer

Language:

English

Submitter:

Katharina Klink

Date Deposited:

18 Sep 2017 10:13

Last Modified:

18 Sep 2017 10:13

Publisher DOI:

10.1007/s00221-016-4771-9

PubMed ID:

27637595

Uncontrolled Keywords:

Hemispheric lateralization Left hemisphere Visual neglect Visuospatial attention system

BORIS DOI:

10.7892/boris.101479

URI:

https://boris.unibe.ch/id/eprint/101479

Actions (login required)

Edit item Edit item
Provide Feedback