Twist and shout: one decade of meta-analyses of erythropoiesis-stimulating agents in cancer patients

Bohlius, Julia; Tonia, Thomy; Schwarzer, Guido (2011). Twist and shout: one decade of meta-analyses of erythropoiesis-stimulating agents in cancer patients. Acta haematologica, 125(1-2), pp. 55-67. Basel: Karger 10.1159/000318897

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Anemia associated with cancer and cancer therapy is a common and important issue in the treatment of patients with malignant disease. Conventionally, blood transfusions are used to treat severe cancer-related anemia. Short- and long-acting preparations of recombinant human erythropoiesis-stimulating agents (ESAs) offer an alternative treatment option. Multiple studies and subsequent meta-analyses have demonstrated that ESA treatment increases hemoglobin levels and reduces the likelihood of transfusion for a proportion of treated patients. However, studies that attempted to evaluate whether ESAs improve tumor response and survival have generated conflicting evidence. Results of smaller trials reporting improved survival outcomes were contradicted by large randomized controlled trials that reported more deaths in patients receiving ESAs. In addition, there is strong evidence that cancer patients receiving ESAs have an increased risk of thromboembolic and cardiovascular events. We herein review the main meta-analyses published in the field, their strengths and weaknesses, their contribution to patient management and future perspectives for systematic reviews.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Bohlius, Julia and Tonia, Thomai

ISSN:

0001-5792

Publisher:

Karger

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

26 Sep 2017 22:42

Publisher DOI:

10.1159/000318897

PubMed ID:

21150188

Web of Science ID:

000285528400007

BORIS DOI:

10.7892/boris.1017

URI:

https://boris.unibe.ch/id/eprint/1017 (FactScience: 201678)

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