Synapses form in skeletal muscles lacking neuregulin receptors.

Escher, Pascal; Lacazette, E; Courtet, M; Blindenbacher, A; Landmann, L; Bezakova, G; Lloyd, K C; Mueller, U; Brenner, H R (2005). Synapses form in skeletal muscles lacking neuregulin receptors. Science, 308(5730), pp. 1920-1923. American Association for the Advancement of Science 10.1126/science.1108258

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The formation of the neuromuscular junction (NMJ) is directed by reciprocal interactions between motor neurons and muscle fibers. Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated. Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin. We therefore conclude that NRG signaling to muscle is not required for NMJ formation. The effects of NRG signaling to muscle may be mediated indirectly through Schwann cells.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Escher, Pascal

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0036-8075

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

PD Dr. Pascal Escher

Date Deposited:

10 Jul 2017 16:14

Last Modified:

31 Jul 2017 08:31

Publisher DOI:

10.1126/science.1108258

PubMed ID:

15976301

BORIS DOI:

10.7892/boris.101761

URI:

https://boris.unibe.ch/id/eprint/101761

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