Cardiovascular findings in ponies with equine metabolic syndrome

Heliczer, Natalie; Gerber, Vinzenz; Bruckmaier, Rupert; van der Kolk, Johannes Hermanus; Navas de Solís, Cristobal (2017). Cardiovascular findings in ponies with equine metabolic syndrome. Journal of the American Veterinary Medical Association, 250(9), pp. 1027-1035. American Veterinary Medical Association 10.2460/javma.250.9.1027

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OBJECTIVE To determine whether hypertension, high sympathetic tone, resting and exercising arrhythmias, and echocardiographic changes consistent with hypertensive cardiomyopathy were associated with equine metabolic syndrome (EMS) in ponies. DESIGN Prospective case-control study. ANIMALS 19 privately owned ponies with a diagnosis of EMS (history of laminitis, body condition score ≥ 7/9, cresty neck score ≥ 3/5, and abnormal oral sugar test result; cases) and 20 healthy control ponies. PROCEDURES Heart rate (HR), noninvasively measured arterial blood pressure (BP), markers of autonomic tone (splenic volume and HR variability), 24-hour and exercising ECGs, and echocardiograms were compared between cases and controls. RESULTS Compared with controls, cases had a higher mean ± SD HR (44.5 ± 7.5 beats/min vs 38.6 ± 6.8 beats/min) and median mean left ventricular wall thickness (2.0 cm vs 1.8 cm). No differences were identified between groups in BP, splenic volume, HR variability, and number of premature complexes in ECGs. Mean wall thickness was correlated with BP (r = 0.54), high-frequency power (r = -0.71), and ratio of low-to high-frequency power (ϕ = 0.66). Relative wall thickness was correlated with serum insulin concentration (r = 0.71). CONCLUSIONS AND CLINICAL RELEVANCE Ponies with EMS had myocardial hypertrophy that was correlated with insulin response to an oral sugar test, sympathetic and parasympathetic tone, and BP. The heterogeneity and limited sample size of this preliminary study should be considered when drawing conclusions. Cardiovascular changes associated with this syndrome deserve further attention.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Physiology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Heliczer, Natalie; Gerber, Vinzenz; Bruckmaier, Rupert; van der Kolk, Johannes Hermanus and Navas de Solís, Cristobal

Subjects:

600 Technology > 630 Agriculture

ISSN:

0003-1488

Publisher:

American Veterinary Medical Association

Language:

English

Submitter:

Andrea Gassmann-Suter

Date Deposited:

11 Oct 2017 17:21

Last Modified:

11 Oct 2017 17:21

Publisher DOI:

10.2460/javma.250.9.1027

PubMed ID:

28414603

BORIS DOI:

10.7892/boris.101824

URI:

https://boris.unibe.ch/id/eprint/101824

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